A Plexiglas helmet and catheter protection assembly for chronic intravenous administration of drugs in small primates

A restraint and catheter-protection system consisting of a Plexiglas helmet and a nylon-tubing protector line has been developed to permit the long-term study of drug self-administration in monkeys. Frequent observations of monkeys in the system over a period exceeding a year have shown that the technique satisfies the requirements for long-term study of drug administration through an indwelling catheter and avoids several recurring problems inherent in other protection systems. Additional applications of the helmet and protector line are discussed.     

Effects of LY354740, a novel glutamatergic metabotropic agonist, on nonhuman primate hypothalamic-pituitary-adrenal axis and noradrenergic function

The search for novel anxiolytics and antidepressants has focused on compounds with the potential to reduce excessive hypothalamic-pituitary-adrenal (HPA) axis activity. L-glutamate, an excitatory neurotransmitter ubiquitously present within the central nervous system, conceivably plays an important role in activating the neural sites involved in stress modulation. Deactivation of the HPA axis by glutamatergic neurotransmission modulation may represent a novel therapeutic approach. Accordingly, the acute intravenous effects of the novel metabotropic (mGlu2/3) agonist LY354740 were tested on bonnet macaques (Macaca radiata) undergoing acute infusions of yohimbine, a noradrenergic stimulant. Dependent measures were the magnitude of the increase of plasma cortisol and plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) customarily elicited by yohimbine. Next, the effects of 6 weeks of chronic oral administration of LY354740 on baseline (postcapture) plasma cortisol and MHPG levels in comparison to the identical measure in untreated controls were assessed. Subjects chronically treated with LY354740 received yohimbine infusions which were compared to yohimbine infusions and saline infusions in non-LY354740-treated subjects. Preliminary evidence supports the view that acute LY354740 infusion resulted in a marked diminution of yohimbine-induced stress response, as manifest by a substantial attenuation of cortisol and MHPG response observed in comparison to the saline-treated yohimbine condition. Chronic oral administration of LY354740 led to postcapture baseline cortisol levels which were markedly reduced (approximately 50 percent) in comparison to untreated control subjects; however, there were no significant parallel differences in MHPG levels. Yohimbine infusions elicited an increase in cortisol and MHPG levels in both LY354740-treated and non-LY354740-treated subjects, in comparison to declines in cortisol values observed following vehicle infusions (group X time interaction; P<.0001). Chronic LY354740-treated subjects failed to achieve cortisol levels comparable in range to those of untreated subjects primarily because of their low baseline cortisol levels. In contrast, despite equivalent baselines, yohimbine-induced MHPG values were increased overall in the chronically treated group compared to the saline and yohimbine-alone groups. Thus, LY354740 markedly reduced the acute corticoid and noradrenergic response elicited by yohimbine infusion. Chronic administration of LY354740 appears to present a safe and effective mechanism to markedly down-modulate the HPA axis while retaining noradrenergic responsivity.     

Contrasting speech patterns in apraxia of speech and phonemic paraphasia

This study was designed to determine if perceptual phonological analysis would reveal distinctions between patients with apraxia of speech and patients with phonemic paraphasic speech. Test findings from 10 Broca's aphasics with apraxia of speech were compared to findings from 10 paraphasic speakers (5 conduction and 5 Wernicke's aphasics). Several marked differences were revealed. Predominant locus of errors and relative difficulty of different classes of phonemic segments were significant discriminators. There was a nonsignificant trend for substituted phonemes to be further from target phonetically in the paraphasic patients. In addition, the two groups showed certain consistent differences in the types of errors they produced. Apraxic patients produced many errors of transitionalization, while sequencing errors were more typical of the patients with phonemic paraphasia. The findings are interpreted in relation to a neuropsychological model of speech. It is suggested that phonemic paraphasia represents a breakdown mainly in the retrieval of phonological word patterns, while apraxia of speech is characterized predominantly by a disturbance in encoding phonological patterns into appropriate speech movements.     

Symptom-system fit in couples: emotion regulation when one or both partners smoke

In a laboratory smoking experiment, 25 couples in which 1 or both partners continued to smoke despite 1 of them having heart or lung disease discussed a health-related disagreement before and during a period of smoking. Immediately afterward, the partners used independent joysticks to recall their continuous emotional experience during the interaction while watching themselves on video. Participants in dual-smoker couples reported increased positive emotion contingent upon lighting up, whereas those in single-smoker couples reported the opposite. The results highlight the role of smoking in close relationships, particularly in regulating emotional closeness when both partners smoke. Attention to this fit between symptom and system may be useful in helping couples achieve stable cessation.     

Auditory change detection: simple sounds are not memorized better than complex sounds

Previous research has shown that the detectability of a local change in a visual image is essentially independent of the complexity of the image when the interstimulus interval (ISI) is very short, but is limited by a low-capacity memory system when the ISI exceeds 100 ms. In the study reported here, listeners made same/different judgments on pairs of successive "chords" (sums of pure tones with random frequencies). The change to be detected was always a frequency shift in one of the tones, and which tone would change was unpredictable. Performance worsened as the number of tones increased, but this effect was not larger for 2-s ISIs than for 0-ms ISIs. Similar results were obtained when a chord was followed by a single tone that had to be judged as higher or lower than the closest component of the chord. Overall, our data suggest that change detection is based on different mechanisms in audition and vision.     

Evolution, Traits, and the Stages of Human Courtship: Qualifying the Parental Investment Model

ABSTRACT Individual differences are explicitly connected to social interaction in Darwin's notion of sexual selection Traits that increase the probability of successful reproduction will tend to increase in frequency This process operates partly through differential choice, by one sex, of certain traits in the other According to the parental investment model, females frequently have more stringent criteria for the traits they will accept in a mate because they have a relatively larger investment in each offspring Because human mating arrangements often involve a substantial commitment of resources by the male, it is necessary to invoke a distinction between the selectivity involved during casual mating opportunities and the selectivity exercised when choosing a long-term partner Ninety-three undergraduate men and women rated their minimum criteria on 24 partner characteristics at four levels of commitment In line with an unqualified parental investment model, females were more selective overall, particularly on status-linked variables In line with a qualified parental investment model, males' trait preferences depended upon the anticipated investment in the relationship Males had lower requirements for a sexual partner than did females, but were nearly as selective as females when considenng requirements for a long-term partner     

Couple dynamics of change-resistant smoking: toward a family consultation model

Smoking is North America's leading cause of preventable morbidity and mortality. Although effective cessation treatments exist, their overall effect is modest, and they rarely reach the high-risk, health-compromised smokers who need them most. Surprisingly, despite evidence that marital relationship variables predict the success of cessation efforts, family systems ideas have had little impact on current intervention research. We review and critique the cessation literature from a systemic viewpoint, illustrate two couple-interaction patterns relevant to the maintenance of high-risk smoking, and outline a family-consultation (FAMCON) intervention for couples in which at least one partner continues to smoke despite having heart or lung disease. Taking into account ironic processes and symptom-system fit, FAMCON focuses on the immediate social context of smoking, aiming to interrupt well-intentioned "solutions" that ironically feed back to keep smoking going, and to help clients realign important relationships in ways not organized around tobacco usage. Currently in its pilot-testing phase, FAMCON is an adjunctive, complementary approach designed to include collaboration with primary-care physicians and to make smokers more amenable to other, evidence-based cessation strategies.     

Theology's Need for a New Interpretation of Nature: Correlate of the Doctrine of Grace

Abstract : Important aspects of contemporary life—from increasing dependence on technology to climate change, from changing views of human nature to global interactions among varied cultures and religions—demand that theologians consider the best understandings of the world that the sciences can offer. To help support a fully relational trinitarian concept of God, namely, one that offers a richer interpretation of God's relationship with the world, theology needs truth about the world, humans, and our place in relation to the rest of nature. Lutheran theological foci have a built‐in thirst that only dialogue with science can quench. Too narrow an approach to anthropology and justification by faith focuses on God's activity on behalf of humans as if apart from nature. We need a more comprehensive vision of God's activity in creation, redemption and sanctification by grace. To explicate this, we turn to Luther's emphasis on God's incarnation in human flesh and blood—thus also in the cells, molecules, and subatomic activity of the world; the communication of attributes; and the indwelling Christ. For a deeper understanding of God as triune and of redemption, we need a renewed emphasis on the connection between creation, incarnation and redemption, and between nature and grace. An increased knowledge of science contributes to a healthier approach to the church's mission by giving a theological basis for ethical action in relation to the (natural) world.