Neurosteroids in the Hippocampus: Neuronal Plasticity and Memory

The hippocampus, which is critically involved in learning and memory processes, is known to be a target for the neuromodulatory actions of steroid hormones produced by the adrenal glands and gonads. Much of the work of B.S. McEwen and collaborators has focused on the role of glucocorticosteroids and estrogen in modulating hippocampal plasticity and functions. In addition to hormones derived from the endocrine glands, cells in the hippocampus may be exposed to locally synthesized neurosteroids, including pregnenolone, dehydroepiandrosterone and their sulfated esters as well as progesterone and its reduced metabolites. In contrast to hormones derived from the circulation, neurosteroids have paracrine and/or autocrine activities. In the hippocampus, they have been shown to have trophic effects on neurons and glial cells and to modulate the activity of a variety of neurotransmitter receptors and ion channels, including type A gamma-aminobutyric acid, N-methyl-D-aspartate and sigma receptors and N- and L-type Ca2+ channels. There is accumulating evidence that some neurosteroids, in particular pregnenolone sulfate, have strong influences on learning and memory processes, most likely by regulating neurotransmission in the hippocampus. However, the hippocampus is not the only target for the mnesic effects of neurosteroids. Associated brain regions, the basal nuclei of the forebrain and the amygdaloid complex, are also involved. Some neurosteroids may thus be beneficial for treating age- or disease-related cognitive impairments.     

“This is My Community”: Reproducing and Resisting Boundaries of Exclusion in Contested Public Spaces

The way that public space is structured has significant implications for identity, social interaction, and participation in society. For those experiencing homelessness, with no or limited private space, survival hinges on the accessibility and livability of public space. However, the increasing privatization of public space in the United States has contributed to the implementation of anti‐homeless ordinances in cities, restricting sitting, standing, panhandling, and sleeping in public. This study analyzes data from interviews with housed and unhoused community members, text from a local policy document, and ethnographic observations to explore how boundaries between “insiders” and “outsiders” are drawn in public space and mediated through individual discourse. Our findings suggest that boundaries of exclusion are constructed through dominant narratives that portray the unhoused as a threat to safety and economic vitality, thus justifying the need for regulation and punishment through the criminalization of homelessness. Yet, informants also demonstrate resistance to this narrative by discussing how criminalization of homelessness perpetuates dehumanization, violence, and economic inequality. Policy implications for the regulation of public space are discussed.     

Construct validity of the Rotter Incomplete Sentences Blank with clinic-referred and nonreferred adolescents

We examined the construct validity of the Rotter Incomplete Sentence Blank (RISB; Rotter, Lah, & Rafferty, 1992) as a measure of psychological maladjustment in adolescents. In Study 1, we investigated the reliability and convergent and discriminant validity of the RISB with adolescents referred to treatment. In Studies 2 and 3, we examined the RISB's ability to differentiate referred and nonreferred adolescents. The RISB showed adequate interrater reliability and converged with self-reported, parent-reported, and teacher-reported social-emotional and behavioral problems. Criterion-related evidence suggests that the RISB may be useful as a screening measure for adolescents using a 135 or 140 cut score. We provide normative data to facilitate the test's use with adolescents in clinical and research settings.     

Specific Psychosocial Issues of Individuals Undergoing Genetic Counseling for Cancer – A Literature Review

Approximately 25 % of individuals undergoing genetic counseling for cancer experiences clinically relevant levels of distress, anxiety and/or depression. However, these general psychological outcomes that are used in many studies do not provide detailed information on the specific psychosocial problems experienced by counselees. The aim of this review was to investigate the specific psychosocial issues encountered by individuals undergoing genetic counseling for cancer, and to identify overarching themes across these issues. A literature search was performed, using four electronic databases (PubMed, PsychInfo, CINAHL and Embase). Papers published between January 2000 and January 2013 were selected using combinations, and related indexing terms of the keywords: ‘genetic counseling’, ‘psychology’ and ‘cancer’. In total, 25 articles met our inclusion criteria. We identified the specific issues addressed by these papers, and used meta-ethnography to identify the following six overarching themes: coping with cancer risk, practical issues, family issues, children-related issues, living with cancer, and emotions. A large overlap in the specific issues and themes was found between these studies, suggesting that research on specific psychosocial problems within genetic counseling has reached a point of saturation. As a next step, efforts should be made to detect and monitor these problems of counselees at an early stage within the genetic counseling process.     

Theorizing Critical Placemaking as a Tool for Reclaiming Public Space

As economic inequality and segregation continue to grow in the U.S., psychology has an important role to play in exploring and promoting processes that can disrupt social injustice. This paper identifies the privatization of public space as a social problem that contributes to the entrenchment of social, economic, and racial inequality, and advances “critical placemaking” as a tool for reclaiming public space for public use. Drawing from key concepts in environmental psychology, narrative psychology, and community psychology, the proposed framework seeks to theorize the processes by which placemaking may contribute to transforming community narratives and building more inclusive, participatory, and democratic communities. Policy implications and future directions for empirical work are discussed.     

Construct Validity of the Rotter Incomplete Sentences Blank With Clinic-Referred and Nonreferred Adolescents

Inferred latent entities, whether those of psychoanalysis, factor analysis, or cluster analysis, have declined in value for many clinical psychologists, both as tools of practice and as objects of theoretical interest. Behavior modification, rational-emotive therapy, crisis intervention, psycho-pharmacology, and actuarial prediction all tend to minimize reliance on latent entities in favor of purely dispositional concepts. Behavior genetics is, however, a powerful movement to the contrary. As regards categorical entities (types, taxa, syndromes, diseases), history reveals no impressive examples of their discovery by cluster algorithms; whereas organic medicine and psychopathology have both discovered many taxonic entities without reliance on formal (statistical) cluster methods. I offer eight reasons for this strange condition, with associated suggestions for ameliorating it. Adopting a realist instead of a fictionist approach to taxonomy, I give high priority to theory-based mathematical derivation of quantitative consistency tests for all taxometric results. I urge a large scale cooperative survey of taxometric methods based on Monte Carlo runs, biological pseudoproblems where the true taxon is independently known, and live problems in genetics, organic medicine, and psychopathology. An empirical example of taxometric bootstrapping and consistency testing was presented from my own current research on schizotypy.