Inhibition of the LH Surge by Restraint Stress in Cyclic Rats: Studies on the Role of GABAA and GABAB Receptors

There is evidence that stress can alter the activity in the brain of gamma-aminobutyricacid (GABA), a neurotransmitter that has been implicated in the regulation of LH secretion. In the present study the role of GABA in the restraint stress-induced inhibition of the LH surge was investigated in the intact cyclic rat. Intracerebroventricular (icv) administration of the GABAA receptor agonist muscimol (0.1, 0.5 or 1 μg) 5 min before the presumed onset of the pro-oestrous LH surge (at 0900 h) caused a dose dependent suppression of the surge. A single dose of the GABAB receptor agonist baclofen (1 μg; icv) injected at 0855 h postponed the onset of the LH surge, and repeated injections at 0855 and 1130 h suppressed the surge. These data indicate that GABA-ergic activity in the brain can inhibit the LH surge in the cyclic rat via GABAA and GABAB receptors. Pro-oestrous rats were subjected to 5 hrs of restraint starting at 0855 h. Pretreatment with the GABAA receptor antagonist bicuculine (1 μg; icv) at 0840, 0940 and 1040 h or pretreatment with the GABAB receptor antagonist phaclofen (10 μg; icv) at 0840 h were ineffective in preventing the restraint-induced inhibition of the LH surge. The results suggest that GABAA and GABAB receptors are not involved in the inhibitory effect of restraint stress on the LH surge.     

Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

Matters of conscience and conscientiousness: the place of ego development in the Five-factor model

The Five-factor model (FFM; Digman, 1990; Goldberg, 1990) and Loevinger's (1994) theory of ego development are two active research traditions that are often construed as incompatible approaches to the study of personality. For example, each theory proposes a different view of the concept of conscientiousness. Loevinger argued that FFM conscientiousness, which emphasizes attributes such as order, self-discipline, and achievement striving, lacks a moral component and is more similar to the conformist stage in her theory. To investigate these claims, we administered the Revised NEO-Personality Inventory (NEO-PI-R; Costa & McCrae, 1992) and the Washington University Sentence Completion Test (WUSCT; Hy & Loevinger, 1996) to 120 university students on 2 separate occasions. Together, the five traits of the FFM significantly predicted item sum scores from the WUSCT (multiple R = .54). Unique linear relationships of Openness to Experience and Agreeableness with ego level demonstrated that the two theories proposed similar constructs. We argue that these two FFM dimensions have conceptual relevance to the cognitive and interpersonal aspects of the ego development construct. We draw further connections between these FFM dimensions, ego development, and human values.     

Building a Bridge of Trust: Collaborative Assessment With a Person With Serious Mental Illness

Collaborative assessment utilizes psychological testing to help people make positive changes in their lives. Limited research has evaluated the utility of collaborative assessment for persons with serious mental illness. This case example uses the Personality Assessment Inventory to illustrate the usefulness of collaborative assessment with a person with serious mental illness. This approach informed not only diagnostic considerations but also revealed the client's current level of distress, contributed to enhanced therapeutic alliance, and directly pointed to psychiatric rehabilitation strategies.     

大学二年级学生人际宽恕与报复心理及其与抑郁的关系研究

采用沉思量表、报复动机量表、宽恕倾向量表、宽恕态度量表和流调中心用抑郁量表对236名大二学生进行问卷调查,综合探讨大学生人际宽恕和报复心理及其与抑郁的关系。研究发现:(1)男大学生的报复倾向显著高于女大学生。(2)宽恕倾向与报复倾向及对侵犯的沉思程度显著负相关。沉思程度和抑郁显著正相关。(3)沉思程度和宽恕倾向对抑郁分别具有显著的正向和负向的预测作用。(4)大学生的宽恕倾向和宽恕态度的相互作用以及宽恕倾向和报复倾向之间的交互作用对抑郁均没有显著预测作用。     

Building a bridge of trust: collaborative assessment with a person with serious mental illness

Collaborative assessment utilizes psychological testing to help people make positive changes in their lives. Limited research has evaluated the utility of collaborative assessment for persons with serious mental illness. This case example uses the Personality Assessment Inventory to illustrate the usefulness of collaborative assessment with a person with serious mental illness. This approach informed not only diagnostic considerations but also revealed the client's current level of distress, contributed to enhanced therapeutic alliance, and directly pointed to psychiatric rehabilitation strategies.     

Information processing bias against emotional facial expressions in social anxiety

The present study examined whether information processing bias against emotional facial expressions is present among individuals with social anxiety. College students with high (high social anxiety group; n  = 26) and low social anxiety (low social anxiety group; n  = 26) performed three different types of working memory tasks: (a) ordering positive and negative facial expressions according to the intensity of emotion; (b) ordering pictures of faces according to age; and (c) ordering geometric shapes according to size. The high social anxiety group performed significantly more poorly than the low social anxiety group on the facial expression task, but not on the other two tasks with the nonemotional stimuli. These results suggest that high social anxiety interferes with processing of emotionally charged facial expressions.     

Toward an Integration of Interpersonal Risk Models of Depression and Cognitive‐Behaviour Therapy

Empirical research has increasingly focused on interpersonal variables associated with the development and maintenance of depression. This article outlines some key interpersonal risk factors for depression, including anxious attachment, sociotropy, excessive reassurance seeking, interpersonal stress generation, reduced social support, social skills deficits, and social avoidance. Recommendations are made for how cognitive‐behavioural therapy may be adapted to address such factors. Specifically, suggestions are offered for how cognitive and behavioural interventions, such as cognitive restructuring, behavioural activation, behavioural experiments, and skills training, may be used with depressed clients to promote positive relationships and reduce maladaptive interpersonal behaviours.     

Ego Development and the Internalization of Conflict in Young Adults

The theory and measurement of ego development (Loevinger in Ego development: Conceptions and theories. Jossey-Bass, San Francisco, 1976) have enjoyed success in the empirical literature as a means of conceptualizing psychological maturity. One unresolved issue concerns the uncertain relationship between ego development and positive adjustment or well-being. The current study tests the hypothesis that ego development in the transition to young adulthood entails an increase in internalizing symptoms and a decrease in externalizing symptoms of psychopathology. Two samples of college students (total n = 263, age range 18–22 years) completed a measure of ego development, the Washington University Sentence Completion Test (WUSCT; Hy and Loevinger in Measuring ego development. Lawrence Erlbaum, Mahwah, 1996), and either the Defense Mechanisms Inventory (DMI; Ihilevich and Gleser in Defense mechanisms: Their classification, correlates, and measurement with the Defense Mechanisms Inventory. Psychological Assessment Resources, Odessa, 1993) or select scales from the Personality Assessment Inventory (PAI; Morey in Personality Assessment Inventory professional manual 2. Psychological Assessment Resources, Lutz, 2007). Results indicate that WUSCT scores are positively correlated with internalizing defense preferences, anxiety-related disorders, unstable mood and identity, and sense of stress. WUSCT scores are negatively correlated with externalizing defense preferences and alcohol problems, and with aggression in males. These findings are consistent with the hypothesis that ego development is related to the specific type, rather than overall level, of psychopathology experienced by young adults.