Smooth-pursuit eye movement dysfunction and liability for schizophrenia: implications for genetic modeling.

Forty-one nonpsychiatric subjects, 38 probands with schizophrenia, and 99 of their relatives were studied. Oculomotor functioning was bimodally distributed for probands and relatives. Oculomotor dysfunction was not present in all families with a schizophrenic proband. In those families in which it was present, there were significant phenotypic correlations between oculomotor functioning and schizophrenia-related characteristics. The patterns of familial resemblance in the families in whom oculomotor dysfunction was present were consistent with nonadditive genetic variance contributing both to oculomotor dysfunction and to the relationship between oculomotor dysfunction and clinical symptoms. These results suggest that schizophrenia may be etiologically heterogeneous and that oculomotor dysfunction may help to identify nonadditive genetic variance for this disorder.     

Fluency versus conscious recollection in the word completion performance of amnesic patients

To examine the relative contribution of fluency and recollection to the word completion performance of amnesics, we administered a task in which patients were told specifically not to utilize previously presented words during stem completion (an Exclusion condition). This condition was contrasted with a standard word completion task in which patients were encouraged simply to complete the stem with the first word that came to mind (an Inclusion condition). Since the exclusion condition necessitated controlled respecification of the initial presentation, it was hypothesized that amnesics would be less able than controls to exclude study list items. Consistent with this hypothesis, the results indicated that the amnesics' performance, unlike that of the alcoholic controls, did not significantly differ as a function of task condition. To examine whether amnesics' conscious recollection could be enhanced, Experiment 2 presented the study list five times. The amnesics now were able to exclude a significant number of items from the study list; however, they still did so considerably less frequently than alcoholic controls. For the alcoholic controls, increasing the number of study trials had little additional effect on their exclusion performance, but it significantly enhanced their inclusion performance. Taken together, these findings suggest that for control subjects, word completion performance is likely mediated by a combination of fluency and recollection, while for amnesic patients, performance is almost exclusively based on the fluency with which an item comes to mind.     

Coping strategies and diastolic blood pressure

An organizational field study involving 95 civil service employees examined the ways these individuals coped with the stressful events of their daily living. Lazarus' cognitive-phenomenological analysis of psychological stress provided the theoretical framework. Subjects indicated on Lazarus' Ways of Coping Checklist those coping thoughts and actions used in the specific encounter described as stressful. As hypothesized, individuals experiencing higher diastolic blood pressure were more likely to cope using strategies characterized by wishful thinking, avoidance, and minimization of threat than were individuals exhibiting lower blood pressure. Implications from both an individual and organizational perspective are discussed.     

The "second skin": perceptions of disturbed and nondisturbed early adolescents on clothing, self-concept, and body image

The purpose of this investigation was to determine if there were differences between regular education and emotionally disturbed early adolescents with respect to self-concept, body image, and selected uses of clothing. A questionnaire was administered to 74 regular education students from three middle schools. An additional 27 students labeled emotionally disturbed were surveyed from one of the schools. The questionnaire contained existing measures of self-concept and body cathexis and a revised clothing scale developed by the authors. Analysis of the data using t tests revealed significant differences between the groups with regard to self-concept and body image. In both cases, regular education students perceived themselves more positively than did those labeled emotionally disturbed. Factor analysis of the clothing-use measure gave rise to five distinct factors, one of which revealed a significant difference between the groups when analyzed by t tests. This factor, "dependence," examined the emotional effects of the use of clothing on individuals, such as the ability to influence mood. The emotionally disturbed students were less likely to use clothing to influence mood than were the regular education students. The results of this investigation lend further credence to the importance of self-concept in the education curriculum, and imply that the usual aspects of the curriculum that deal with self-concept may be served better by helping the individual become more realistic and self-accepting. The use of clothing as a tool to enhance self-concept merits further investigation.     

The Politics of Pears: Augustine on the Ethics of Privative Versus Eucharist Communities

In my essay, I interpret Augustine's Confessions as a political text that portrays Augustine's attempt to find a true community. This search includes a critique of various defective communities that cannot provide the public good necessary for a true public. To show this, I focus on Augustine's account of the pear theft as an example par excellence of a privative community. I examine the story as an account of an inexplicable act of willing against the good that unmakes the will. I then argue that the supposed resolution—that Augustine was willing the good of community—in fact exacerbates the inexplicability of the pear theft. In feasting on iniquity, this community un-makes itself. I conclude by showing how the pear thieves represent a perverted imitation of the eucharistic community, which does not steal but shares the Good and so shares its goods.     

Using self-evaluation to improve difficult-to-read handwriting of secondary students

We used delayed multiple-baseline and multiple-probe techniques to assess the effects of self-evaluation training on the legibility of cursive handwriting. Five secondary special education students with difficult-to-read handwriting served as participants. All participants improved the legibility of their handwriting during self-evaluation training. A systematic withdrawal of the training package demonstrated maintenance of treatment effects. For the most part, the students' handwriting remained at least 90% legible to judges following the systematic withdrawal of the self-evaluation training.     

Pursuit gain and saccadic intrusions in first-degree relatives of probands with schizophrenia

Oculomotor functioning of 26 probands with schizophrenia, 12 spectrum and 46 nonspectrum first-degree relatives, and 38 nonpsychiatric control subjects was evaluated. Spectrum relatives had more anticipatory saccades (ASs) and lower pursuit gain than nonspectrum relatives, who had more ASs and lower pursuit gain than control subjects. Probands also had lower pursuit gain than nonspectrum relatives and control subjects but did not differ from other groups on AS frequency. Control subjects had more globally accurate pursuit tracking (root mean square [RMS] error deviation) than both relative groups, whereas probands had the poorest RMS scores. Square wave jerk frequency did not differentiate the groups. Attention enhancement affected the frequency of ASs but did not affect either the other intrusive saccadic event or RMS scores. These results offer evidence that eye-movement dysfunction may serve as a biological marker for schizophrenia.     

Is eye movement dysfunction a biological marker for schizophrenia? A methodological review

There is a high prevalence of eye movement dysfunction (EMD) in persons with schizophrenia and their first-degree relatives. Studies addressing the prevalence, stability, familial transmission, and psychological correlates of EMD in persons from both psychiatric and general populations offer suggestive evidence that this abnormality may serve as a biological marker for schizophrenia. Although these findings are promising, their significance for elucidating the diagnostic bandwidth, pathophysiology, and genetics of this disorder remains to be determined. More precise characterization of ocular motility, perhaps when used in conjunction with global measures of pursuit adequacy, may be essential for clarifying the pathophysiological and genetic significance of EMD for schizophrenia. Recent research efforts are beginning to identify particular abnormalities that could serve as more specific biological markers for schizophrenia.     

Neuropsychological significance of phonetically accurate and phonetically inaccurate spelling errors in younger and older retarded spellers

The performances of two groups of retarded spellers (who were equated with respect to the level of deficient performance in spelling, but who differed in the level of phonetic accuracy of their misspellings) at two different age levels were compared to those of normal spellers who had been matched for age and WISC Performance IQ with the retarded spelling groups. The results indicated very marked differences in a number of linguistic skills between the normal spellers and the retarded spellers whose misspellings were characterized by phonetic inaccuracy. The performances of the retarded spellers who produced a preponderance of phonetically accurate misspellings differed markedly from those of the normal spellers only when the task demands involved fairly complex linguistic-cognitive operations. For the most part, the differences among the three groups were in evidence only at the older age level studied.