Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts

Rats have a natural tendency to spend more time exploring novel objects than familiar objects, and this preference can be used as an index of object recognition. Rats also show an exploratory preference for objects in locations where they have not previously encountered objects (an index of place memory) and for familiar objects in contexts different from those in which the objects were originally encountered (an index of context memory). In this experiment, rats with cytotoxic lesions of the hippocampal formation were tested on all three versions of the novelty-preference paradigm, with a 5-min retention interval between the familiarization and test phases. Rats with sham lesions displayed a novelty preference on all three trial types, whereas the rats with hippocampal lesions displayed a novelty preference on Object trials but did not discriminate between the objects on Place trials or Context trials. The findings indicate that hippocampal damage impairs memory for contextual or spatial aspects of an experience, whereas memory for objects that were part of the same experience are left relatively intact.     

The paradox of quetiapine in obsessive-compulsive disorder

Schizophrenia and obsessive-compulsive disorder (OCD) have historical, clinical, and epidemiological links. The clinical use of atypical neuroleptics (ie, dual serotonin-dopamine antagonists) to treat both conditions sheds a new light on them. We report the first two cases of obsessive-compulsive symptoms (OCS) induced by quetiapine in schizophrenia patients. A case of successful augmentation by quetiapine in refractory OCD is also presented. A review of the literature on OCS induced by atypical neuroleptics follows. This paradoxically induced OCD symptomology in schizophrenia patients administered atypical neuroleptics is discussed from new pathophysiological and clinical perspectives. The discussion emphasizes the prognostic implications of OCS in schizophrenia and available therapies for this comorbidity.     

Lacan's Concept of Desire and its Vicissitudes

This paper counterbalances Lacan's dictum that desire is structured like a signifying chain by highlighting his dependence on a biological understanding of the sexual drive. Reiterating (and reinterpreting) Freud's “leaning on”—hypothesis about the genesis of desire, Lacan maintains that the sexual drive originates in the vital function. His ideas about male and female sexuality most clearly presuppose a biological understanding of the sexual drive. At various times, Lacan blurs the lines of his own conceptual difference between phallus and penis, up to the point of reducing the difference between the sexes to an opposition.     

Catholic Reflections for an Updated Donum Vitae Instruction: A New Catholic Challenge in a Post-Christian Europe

On February 22, 1987, the Congregation for the Doctrine of theFaith published the Donum Vitae Instruction. Twenty years later,on February 22, 2007, Pope Benedict XVI asked for an updateof this Instruction. According to the Donum Vitae Instructionof 1987, the principle of the holiness of life imposes respectfor human persons from the very beginning of human life. Inthese past 20 years, new medical techniques have raised freshethical issues that are to be addressed by the Roman CatholicChurch Magisterium. The Roman Catholic Church, in its updateof the Instruction planned for 2007, will have to explain howcivil law is to be regulated according to the fundamental normsof the moral law. The moral message of the new Donum Vitae (justas in the 1987 version) will be to affirm the substance of humanjustice: respect for human life, as expressed in the resolvenot to infringe on, or to protect such life. Even in a post-ChristianEurope, this theological message can be understood if it istrue that Europe is marked by the principle of the absoluteprotection of human life.     

New phenomenon of abnormal auditory perception associated with emotional and head trauma: pathological confirmation by SPECT scan

We report the case of an immigrant who suffered from death threats and head trauma while a prisoner of war in Kuwait. Two months later, he began to hear conversations that had taken place previously. These perceptions occurred spontaneously or were induced by the patient's effortful concentration. The single photon emission computerized tomography (SPECT) scan performed during this abnormal perceptual experience indicated an increase in regional cerebral blood flow in the left temporal lobe and in the brainstem.     

Spatial frequency thresholds for face recognition when comparison faces are filtered and unfiltered

Previous work has shown an advantage of middle spatial frequencies (SFs) in face recognition. However, a few recent studies have suggested that this advantage is reduced when comparison and test stimuli are spatially filtered in a similar way. In the present study, we used standard psychophysical methods, in combination with a match-to-sample task, to determine the SF thresholds for face matching under conditions in which: (1) comparison stimuli were unfiltered and (2) comparison stimuli were spatially filtered in the same way as test stimuli. In two experiments, we show that SFs closer to the middle band are sought out more in the former case than in the latter. These results are compatible with the idea that a middle band of SFs will be most useful for any visual task and that the breadth of this optimal middle band will vary depending on task characteristics.     

The concept possession hypothesis of self-consciousness

This paper presents the hypothesis that concept possession is sufficient and necessary for self-consciousness. If this is true it provides a yardstick for gauging the validity of different research paradigms in which claims for self-consciousness in animals or human infants are made: a convincing demonstration of concept possession in a research subject, such as a display of inferential reasoning, may be taken as conclusive evidence of self-consciousness. Intuitively, there appears to be a correlation between intelligence in animals (which presupposes concept possession) and the existence of self-consciousness. I present three discussions to support the hypothesis: an analogy between perception and conception, where both are self-specifying; an argument that any web of concepts will always include the self-concept; and a fresh interpretation of Bermũdez (1998) showing how his theory of non-conceptual content provides strong support for the concept possession hypothesis.     

Hierarchical Error Evaluation: The Role of Medial-Frontal Cortex in Postural Control

Motor error evaluation appears to be a hierarchically organized process subserved by 2 distinct systems: a higher level system within medial-frontal cortex responsible for movement outcome evaluation (high-level error evaluation) and a lower level posterior system(s) responsible for the mediation of within-movement errors (low-level error evaluation). While a growing body of evidence suggests that a reinforcement learning system within medial-frontal cortex plays a crucial role in the evaluation of high-level errors made during discrete reaching movements and continuous motor tracking, the role of this system in postural control is currently unclear. Participants learned a postural control task via a feedback-driven trial-and-error shaping process. In line with previous findings, electroencephalographic recordings revealed that feedback about movement outcomes elicited a feedback error–related negativity: a component of the human event-related brain potential associated with high-level outcome evaluation within medial-frontal cortex. Thus, the data provide evidence that a high-level error-evaluation system within medial-frontal cortex plays a key role in learning to control our body posture.     

Lone‐Actor Terrorists’ Emotions and Cognition: An Evaluation Beyond Stereotypes

Lone‐actor terrorists are very often presented as emotionally and/or cognitively impaired—yet is it really the case? The present article provides the first rigorous assessment of the hypotheses according to which a high level of negative emotions, especially anger, and a lack of cognitive flexibility and complexity play a role in lone‐actor terrorists’ violent actions. Using a sample of lone‐actor terrorists’ writings, we use the LIWC (a fully automated language use analysis software) to compare terrorists’ cognition and emotion with those of other control groups, most notably nonviolent radical activists. Results strongly support the first hypothesis but clearly refute the second one, suggesting that lone‐actor terrorists are in fact characterized by a specific combination of high‐anger and high‐cognitive complexity. These method and results lay the groundwork for a more systematic and nuanced analysis of the psychology of terrorists, which is currently in a deadlock.