Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

Storywork in STEM-Art: Making,Materiality and Robotics within Everyday Acts of Indigenous Presence and Resurgence

Abstract

This article presents findings from TechTales, a participatory design research (PDR) project where learning scientists, public library staff members, informal science educators, and staff members from Native-American-serving organizations collaborated to design a family-based robotics workshop that was grounded in storytelling. We approach this by engaging Indigenous ways of knowing and being from a sociocultural learning theory perspective. Through analyzing families-in-interaction as they constructed dioramas with robotics that told their family stories, we explore how cultivating consequential learning environments in STEM is intimately intertwined with historicity, knowledge systems, and the agentic positioning of learners to design new technologies. We find that using storywork as the design focus of building dioramas created learning environments where computer programing and robotics became dynamic tools toward family-making, collaboration, and the active presencing of Indigenous knowledge systems and cultural practices. Living and interrelating with story and its knowledge systems through making were enactments of Indigenous resurgence in everyday ways. From a structure of social practices perspective, this opens up learning spaces for engagement in STEM-Art practices and in relation to other social practices of consequence, such as cultural flourishing and affiliation, collaboration and family-making, and societal repositioning.     

Questioning the Presumption of Naturalism in the Social Sciences: A Case Study

An important consensus has occurred across the social sciences: The best philosophy for guiding knowledge advancement omits any substantive reference to an active transcendent being. This philosophy of naturalism is so prevalent that social science disciplines renowned for examining research philosophies, such as anthropology, overlook naturalism. This article describes an anthropological case in point: E. E. Evans-Pritchard’s study of the Azande people. Evans-Pritchard is noted for his thoughtful and thorough cultural studies, and the Azande are noted for their unorthodox, non-naturalistic beliefs. We describe the interaction of this anthropologist and culture and find that he presumes a reified naturalism, which dramatically affects his understanding and treatment of this non-naturalistic culture. We then proffer several lessons and implications for pastoral psychology and psychotherapy that follow from our case study.     

The making of contemporary American psychiatry, Part 2: therapeutics and gender before and after World War II

In this article, the 2nd in a 2-part series, the authors use patient records from California's Stockton State Hospital to explore the changing role of gender norms and other cultural values in the care of psychiatric patients. The authors show that cultural values are always imbedded in psychiatric practice and that their role in that practice depends on the patients, treatments, and therapeutic rationales present in a given therapeutic encounter. Because the decade following World War II witnessed dramatic changes in psychiatry's patients, therapeutics, and rationales, Stockton State Hospital's patient records from this time period allow the authors to show not only the extent to which gender norms shape psychiatric practice but also how psychiatry's expansion into the problems of everyday life has led to psychiatry taking a more subtle and yet more active role in enforcing societal norms.     

Two Approaches to Religion and Politics: Moral Cosmology and Subcultural Identity*

We explore two competing approaches to internal religious divisions and their political consequences. The “moral cosmology” approach focuses on religious worldviews. It juxtaposes the religiously orthodox to modernists, arguing that the former are theologically communitarian in belief while the latter are individualistic. The religiously orthodox worldview (relative to modernists) is posited to lead to politically conservative stances on cultural issues of abortion, sexuality, and family but politically liberal stances on economic issues. In contrast, the “subcultural identity” approach focuses on identity rather than worldview. According to this approach, self‐identified evangelicals and fundamentalists are expected to be more politically conservative on both cultural and economic issues when compared to mainline or liberal Protestants. Through analyses of the 1998 GSS, which allows operationalization of the two approaches and their extension to Catholic identities, we find that cosmology and identity are associated, but they have independent—and sometimes opposite—effects on Americans’ political beliefs.     

Discrimination,Internalized Homonegativity,and Attitudes Toward Children of Same‐Sex Parents: Can Secure Attachment Buffer Against Stigma Internalization?

With increasing numbers of same‐sex couples raising children in the United States, discriminatory attitudes toward children of same‐sex parents (ACSSP) are of increasing concern. As with other forms of stigma and discrimination, lesbian, gay, and bisexual (LGB) individuals are at risk for internalizing these societal attitudes, which can negatively affect parenting‐related decisions and behaviors and the mental and physical health of their children. Secure attachment is characterized by positive views of the self as loveable and worthy of care that are understood to develop in early relationships with caregivers. Secure attachment has been associated with positive mental and physical health, including among LGB individuals and couples. This study aimed to test the potential buffering role of secure attachment against stigma internalization by examining associations among secure attachment, discrimination, internalized homonegativity (IH), and ACSSP in an online survey study of 209 U.S. adults in same‐sex relationships. Bootstrap analyses supported our hypothesized moderated mediation model, with secure attachment being a buffer. Greater discrimination was indirectly associated with more negative ACSSP through greater IH for individuals with mean or lower levels, but not for individuals with higher than average levels of secure attachment, specifically because among those with higher levels of secure attachment, discrimination was not associated with IH. These findings build on and extend past research, with important implications for future research and clinical work with LGB individuals, same‐sex couples, and their families, including potential implementation of interventions targeting attachment security.     

Weight-related words associated with figure silhouettes

Antifat attitudes and obesity bias are prevalent in Western society; however, little is known about the social meanings and connotations of weight-related words such as fat, overweight, and obese (e.g., Robison & Erdman, 1998). The purpose of this study was to explore college students' perceptions of weight-related terminology. Participants (n=131) completed a modified figure rating scale in which they identified male and female figure silhouettes most associated with a variety of weight-related words and personal characteristics. Additionally, participants completed a word association task and provided definitions of five weight terms. Results indicated that participants grouped weight terms into two groupings (i.e., "slender" and "heavy" weight terms) both in the figure rating task and in the word association and definition tasks. Both male and female participants selected smaller female figure silhouettes for the weight terms overweight, large, fat, and normal weight than for the male figure silhouettes. Moreover, associations between weight-related words and personal characteristics, including normal weight -physically fit and overweight -lazy, were found. The results suggest that weight-related words carry with them social meanings and values that reflect an "ideology of blame."     

Predicting the suicide attempts of lesbian, gay, and bisexual youth

In this study predictors of serious suicide attempts among lesbian, gay, and bisexual (LGB) youth were examined. Three groups were compared: youth who reported no attempts, youth who reported attempts unrelated to their sexual orientation, and youth whose attempts were considered related to their sexual orientation. About one third of respondents reported at least one suicide attempt; however, only half of the attempts were judged serious based on potential lethality. About half of all attempts were related to youths' sexual orientation. Factors that differentiated youth reporting suicide attempts and those not reporting attempts were greater childhood parental psychological abuse and more childhood gender-atypical behavior. Gay-related suicide attempts were associated with identifiability as LGB, especially by parents. Early openness about sexual orientation, being considered gender atypical in childhood by parents, and parental efforts to discourage gender atypical behavior were associated with gay-related suicide attempts, especially for males. Assessment of past parental psychological abuse, parental reactions to childhood gender atypical behavior, youths' openness about sexual orientation with family members, and lifetime gay-related verbal abuse can assist in the prediction of suicide attempts in this population.