Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

Evaluating Sources of Ego-Threatening Feedback: Self-Esteem and Narcissism Effects

High self-esteem individuals in previous studies have tended to deny the credibility of negative evaluators. The present research examined possible explanations for this finding and compared the effects of self-esteem and narcissism on evaluations of negative feedback sources. Following bogus negative feedback, self-esteem predicted negative evaluations of a nonperson feedback source and positive affect, as expected from consistency theory; narcissism predicted negative evaluations of a person feedback source and hostile affect, as expected from threat-derogation and narcissism theory. Results indicate the importance of distinguishing between healthy and defensive self-esteem in understanding responses to negative feedback.     

Screening for personality disorders in a nonclinical population

Based on the Inventory of Interpersonal Problems (IIP), the IIP-PD and the IIP-C screening scales were developed to distinguish personality disorder (PD) from non-PD and Cluster C from other PD, respectively, in a clinic population. Two studies were conducted to determine (a) validity and reliability of these IIP scales for PD screening in a nonclinical population, (b) specificity of IIP-C for identifying Cluster C, and (c) usefulness of the IIP scales for screening Cluster A. College students were screened using the IIP scales (Study 1, N = 454, Study 2, N = 87). High and low scorers completed PD-related questionnaires in Study 1 and a clinical interview for PD symptomatology in Study 2. Results indicated strong test-retest reliability, internal consistency, and factorial, convergent, and external validity. The scales tapped a common deficit in interpersonal relatedness, with some distinction between externalizing and internalizing dimensions, respectively, and both scales were positively and significantly associated with schizotypal traits. In conclusion, the IIP-PD and IIP-C are useful and valid screening instruments for identifying any versus no PD in nonclinical populations.     

Young Women’s Experience of Anorexia,Family Dynamics and Triangulation

The study explored the experience of triadic family relationships of six young women with a diagnosis of Anorexia Nervosa alongside a consideration of their attachment strategies. The research methods employed semi-structured individual interviews, a family sculpt and use of an adapted version of the Adolescent Separation Anxiety Test (SAT). This adaptation featured a unique development for this study of photographs depicting triadic family separation and conflict situations. These attempted to offer an integrated view of their experience of anorexia and of family relationships alongside a consideration of the attachment strategies evoked. Interpretative Phenomenological Analysis was used to generate themes that captured the young women’s experience, and a modified version of the SAT protocol coding was used to explore attachment strategies. The main themes to emerge from the data were found to be: Relational distance to attachment figures, Barriers to emotional connection, and Perception of parents’ relationship. Attachment strategies were shown to influence perceptions of family relationships and of triadic processes and conflicts. Clinical implications of the findings are discussed alongside limitations of the study and indications for future research.     

Familial Association and Frequency of Learning Disabilities in ADHD Sibling Pair Families

In a sample of 235 families with at least two children with Attention-Deficit/ Hyperactivity Disorder (ADHD), the frequency and familial association of learning disabilities (LD) were assessed. Familiality was examined both between sibling pairs and between parents and their children. Two methods for defining LD, a discrepancy-based and a low-achievement model, were employed to examine the occurrence of LD in this sample. The specific types of LD examined included Reading Disability (RD), Math Disability (MD), and Writing Disability (WD). The prevalence rates were highest for RD, followed by WD then MD. The two definitions of LD yielded similar prevalence rates but identified different groups of children with vastly different IQ scores. Strong familial association was demonstrated for RD both between sibling pairs and between parents and children, with weaker association for WD. There was evidence of nonrandom mating for LD among parents, but not for ADHD or for ADHD + LD. Despite the high comorbidity of ADHD and LD among parents, the presence of ADHD in the parents did not predict child LD supporting independent familial factors underlying ADHD and LD.     

Randomised controlled pilot trial of mindfulness training for stress reduction during pregnancy

This randomised controlled pilot trial tested a six-week mindfulness-based intervention in a sample of pregnant women experiencing high levels of perceived stress and pregnancy anxiety. Forty-seven women enrolled between 10 and 25 weeks gestation were randomly assigned to either a series of weekly Mindful Awareness Practices classes (n = 24) with home practice or to a reading control condition (n = 23). Hierarchical linear models of between-group differences in change over time demonstrated that participants in the mindfulness intervention experienced larger decreases from pre-to post-intervention in pregnancy-specific anxiety and pregnancy-related anxiety (PRA) than participants in the reading control condition. However, these effects were not sustained through follow-up at six weeks post-intervention. Participants in both groups experienced increased mindfulness, as well as decreased perceived stress and state anxiety over the course of the intervention and follow-up periods. This study is one of the first randomised controlled pilot trials of a mindfulness meditation intervention during pregnancy and provides some evidence that mindfulness training during pregnancy may effectively reduce PRA and worry. We discuss some of the dilemmas in pursuing this translational strategy and offer suggestions for researchers interested in conducting mind-body interventions during pregnancy.     

Resilience Mediates the Relations Between Perfectionism and College Student Distress

This study examined the relations among perfectionism dimensions, resilience, and distress. Participants were 413 undergraduate students. All 3 of Hewitt and Flett's (2004) dimensions of perfectionism were associated with greater reports of depression and anxiety; however, only socially prescribed perfectionism was significantly associated with resilience. Results indicated that resilience partially mediated the relations between socially prescribed perfectionism and distress. Implications for counselors in the prevention, assessment, and treatment of depression and anxiety are discussed.