Associative learning performance is impaired in zebrafish (Danio rerio) by the NMDA-R antagonist MK-801

The zebrafish is gaining popularity in behavioral neuroscience perhaps because of a promise of efficient large scale mutagenesis and drug screens that could identify a substantial number of yet undiscovered molecular players involved in complex traits. Learning and memory are complex functions of the brain and the analysis of their mechanisms may benefit from such large scale zebrafish screens. One bottleneck in this research is the paucity of appropriate behavioral screening paradigms, which may be due to the relatively uncharacterized nature of the behavior of this species. Here we show that zebrafish exhibit good learning performance in a task adapted from the mammalian literature, a plus maze in which zebrafish are required to associate a neutral visual stimulus with the presence of conspecifics, the rewarding unconditioned stimulus. Furthermore, we show that MK-801, a non-competitive NMDA-R antagonist, impairs memory performance in this maze when administered right after training or just before recall but not when given before training at a dose that does not impair motor function, perception or motivation. These results suggest that the plus maze associative learning paradigm has face and construct validity and that zebrafish may become an appropriate and translationally relevant study species for the analysis of the mechanisms of vertebrate, including mammalian, learning and memory.     

Does remembering emotional items impair recall of same-emotion items?

In the part-set cuing effect, cuing a subset of previously studied items impairs recall of the remaining noncued items. This experiment reveals that cuing participants with previously-studied emotional pictures (e.g., fearevoking pictures of people) can impair recall of pictures involving the same emotion but different content (e.g., fear-evoking pictures of animals). This indicates that new events can be organized in memory using emotion as a grouping function to create associations. However, whether new information is organized in memory along emotional or nonemotional lines appears to be a flexible process that depends on people’s current focus. Mentioning in the instructions that the pictures were either amusement- or fear-related led to memory impairment for pictures with the same emotion as cued pictures, whereas mentioning that the pictures depicted either animals or people led to memory impairment for pictures with the same type of actor.     

For your Eyes Only: A Q-Methodology on the Ontology of Happiness Among Chronically Ill Filipino Elderly in a Penal Institution

Happiness is a positive phenomenon that is universal in nature and is therefore, pertinent to all human beings. However, the definition of happiness differs from person to person, and varies among cultures, economic status, social connectedness, spiritual upbringing and daily situations. An individual’s contextual perception of happiness can change when subjected to bleak conditions such as incarceration wherein inmates, especially those who are old and are experiencing health impairments are stripped off with their customary source of happiness. Since Filipinos are known to be as “happy people,” this study purports to surface the different facets of what constitute happiness in the context of a penal institution in the Philippine setting. The Q-methodology is the primary design used in the study. It combines the objectivity of quantitative approach with the essence of human experiences as explored in qualitative studies. The participants (P-sample) were twenty elderly inmates suffering from chronic ailments. They were asked to arrange 32 statements (Q-sample), derived from the initial interview, in the Q-sort table based on their degree of agreement, which were then further explicated in the post-sort interviews. The results were then subjected to by-person factor analysis with varimax rotation using the PQ Method version 2.11. Five profiles emerged from the by-person factor analysis, namely: (1) ‘Sense of Affinity’, (2) ‘Sense of Opportunity’, (3) ‘Sense of Indemnity’, (4) ‘Sense of Positivity’ and (5) ‘Sense of Resiliency’. The discussion focused on similarities and differences among profiles regarding the four principal themes (familial, social, internal and spiritual components of happiness) derived from the statements used as the Q-sample. The perception of happiness varies from profile to profile. The differences in views on what constitutes happiness among profiles are more prominent than their said similarities. Most leanings are directed toward the familial and spiritual aspects of happiness however, happiness can also be internally motivated and cognitively construed. While happiness has a direct relationship to an individual’s overall perception of well-being, the nurse, being the primary provider of holistic care, plays a pivotal role in promoting optimum health through awareness, knowledge, and appreciation of vis-a vis an unwavering involvement with the unique and distinct psychological and emotional needs of the elderly inmates characterized by respect, openness, authenticity and inter-subjectivity.     

Effects of hypnosis and imagery training on naming behavior in aphasia

The effects of hypnosis and imagery training on the naming behavior of three subjects with Broca's aphasia were investigated using a multiple baseline design across subjects. Treatment consisted of the induction of hypnosis, followed by guided imagery focused on the physical and functional attributes of stimulus objects. Measures of naming ability on both trained and untrained items were taken at baseline, after every training session, and a few hours after training each day. Measures were also taken of imagery ability, hypnotic susceptibility, and psychological state. Results indicated that treatment facilitated improvement in naming ability, over baseline level, for two subjects. In the case of the third subject, the verbal label was incorporated into the imagery procedure following 10 training sessions. Subsequently, this subject's naming behavior improved over baseline level. The results are discussed in terms of current theory and research in neuropsychology and cognitive psychology.     

A projective analysis of guilt: the Holtzman Inkblot Technique

The group version of the Holtzman Inkblot Technique (HIT) and the three subscales of the Mosher Guilt Scales (Sex Guilt, Hostility Guilt, and Morality-Conscience Guilt) were administered to 44 undergraduate college females in an effort to determine whether or not high-guilt subjects would demonstrate response inhibition on the HIT. The results indicated response inhibition on the part of high-guilt subjects relative to the HIT Human, Movement, and Integration variables. It was concluded that high-guilt subjects responded to the HIT in a style that was less creative and more perceptually immature than low-guilt subjects.     

The combined use of rational-emotive therapy and biofeedback in the treatment of childhood migraine

The available literature on the psychological treatment of childhood migraine was reviewed and evaluated. The current treatment modalities have relled essentially upon biofeedback techniques and neglected the potential cognitive factors that might lead to successful results. A case example is provided that demonstrates the combined treatment of childhood migraine using both biofeedback and rational emotive therapy (RET). Continued relief was reported during a follow-up interview conducted a year and a half after the treatment concluded. While both the biofeedback and RET elements for treatment were considered important for alleviation of the migraine condition, the subject reported that it was the RET training that proved most effective in dealing with stressors related to the onset of migraine attacks.