Human Germline CRISPR-Cas Modification: Toward a Regulatory Framework

CRISPR germline editing therapies (CGETs) hold unprecedented potential to eradicate hereditary disorders. However, the prospect of altering the human germline has sparked a debate over the safety, efficacy, and morality of CGETs, triggering a funding moratorium by the NIH. There is an urgent need for practical paths for the evaluation of these capabilities. We propose a model regulatory framework for CGET research, clinical development, and distribution. Our model takes advantage of existing legal and regulatory institutions but adds elevated scrutiny at each stage of CGET development to accommodate the unique technical and ethical challenges posed by germline editing.     

Metaphysical Rationalism

The Principle of Sufficient Reason states that everything has an explanation. But different notions of explanation yield different versions of this principle. Here a version is formulated in terms of the notion of a “grounding” explanation. Its consequences are then explored, with particular emphasis on the fact that it implies necessitarianism, the view that every truth is necessarily true. Finally, the principle is defended from a number of objections, including objections to necessitarianism. The result is a defense of a “rationalist” metaphysics, one that constitutes an alternative to the contemporary dogmas that some aspects of the world are “metaphysically brute” and that the world could in so many ways have been different.     

Individuals: an essay in revisionary metaphysics

We naturally think of the material world as being populated by a large number of individuals. These are things, such as my laptop and the particles that compose it, that we describe as being propertied and related in various ways when we describe the material world around us. In this paper I argue that, fundamentally speaking at least, there are no such things as material individuals. I then propose and defend an individual-less view of the material world I call “generalism”.