Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

On the naming of color words and color patches

Subjects can name color words faster than they can name color patches. To account for that effect, a generic model of naming is described which assumes that words access the mental lexicon directly, whereas color patches do so only indirectly via an initial imaginal or semantic representation. However, Lund (1927) reported that the naming advantage for words disappeared when all the items to be named on a page were the same (i.e., they were blocked). In the present study, three experiments are reported that were designed to provide a clearer empirical definition of Lund’s blocking effect and to ascertain the extent to which it requires a modification of the generic model. The blocked lists had 50 items arranged into 10 blocks, with each block homogeneous with respect to color. The block lengths were either all a predictable length of 5 items or they varied randomly from 1 to 9 items. The data indicated the following: (1) The blocking effect occurred even when the task required a full identification of each item, and (2) the blocking effect was confined to within-block transitions. Blocking seemed to eliminate the word advantage by allowing the subject to re-use the lexical entry used for the immediately prior item, which is consistent with the generic model.     

Metastable attunement and real-life skilled behavior

In everyday situations, and particularly in some sport and working contexts, humans face an inherently unpredictable and uncertain environment. All sorts of unpredictable and unexpected things happen but typically people are able to skillfully adapt. In this paper, we address two key questions in cognitive science. First, how is an agent able to bring its previously learned skill to bear on a novel situation? Second, how can an agent be both sensitive to the particularity of a given situation, while remaining flexibly poised for many other possibilities for action? We will argue that both the sensitivity to novel situations and the sensitivity to a multiplicity of action possibilities are enabled by the property of skilled agency that we will call metastable attunement. We characterize a skilled agent’s flexible interactions with a dynamically changing environment in terms of metastable dynamics in agent-environment systems. What we find in metastability is the realization of two competing tendencies: the tendency of the agent to express their intrinsic dynamics and the tendency to search for new possibilities. Metastably attuned agents are ready to engage with a multiplicity of affordances, allowing for a balance between stability and flexibility. On the one hand, agents are able to exploit affordances they are attuned to, while at the same time being ready to flexibly explore for other affordances. Metastable attunement allows agents to smoothly transition between these possible configurations so as to adapt their behaviour to what the particular situation requires. We go on to describe the role metastability plays in learning of new skills, and in skilful behaviour more generally. Finally, drawing upon work in art, architecture and sports science, we develop a number of perspectives on how to investigate metastable attunement in real life situations.

     

On the selective relation of frontal cortical asymmetry and anger-out versus anger-control

The model of anterior asymmetry and emotion proposes an asymmetric representation of approach and withdrawal systems in the left and right anterior brain regions. Within this framework, 3 different concepts have been related to anterior asymmetry: affective valence, motivational direction, and behavioral activation. The aim of the present study was an empirical investigation into the relation between anterior cortical activity and questionnaire measures related to the 3 dimensions positive versus negative affect, approach versus withdrawal motivation, and behavioral activation versus inhibition. Subjects with relative greater left than right frontal cortical activity showed higher anger-out scores and lower anger-control scores. These results support the hypothesis that motivational direction is related to frontal asymmetry (approach-left and withdrawal-right). Furthermore, subjects with greater bilateral (left and right) frontal cortical activity showed higher behavioral activation scores. This finding might suggest that behavioral activation is related to approach and withdrawal motivation.     

Intelligenzgeminderte Rechtsbrecher im Maßregelvollzug

Forensic patients with intellectual disabilities have so far received little attention which is reflected in the comparatively briefly written chapters in the standard textbooks and also the low scientific interest in this patient group. There are only few therapeutic concepts and even less information on their effectiveness. This article presents the Christophorus Clinic in Münster which was the first forensic institution in Germany to specialize in these patients. The institution incorporates 54 treatment places and started operating on 3 June 2011. In addition to the known fact that a therapy concept must (further) develop over the years, during the first year of operation some aspects have arisen which have cristallized as problem areas specific for this patient group, which are discussed.     

Skill transfer,affordances and dexterity in different climbing environments

This study explored how skills in one region of a perceptual-motor landscape of performance, created in part by previous experience in rock climbing, can shape those that emerge in another region (ice climbing). Ten novices in rock climbing and five intermediate rock climbers were observed climbing an icefall. Locations of right and left ice tools and crampons were videotaped from a frontal camera. Inter-individual variability of upper and lower limb couplings and types of action regarding icefall properties were assessed by cluster hierarchical analysis, distinguishing three clusters. Pelvis vertical displacement, duration and number of pelvis pauses were also analyzed. Experienced rock climbers were grouped in the same cluster and showed the highest range and variability of limb angular locations and coordination patterns, the highest vertical displacement and the shortest pelvis plateaux durations. Non-fluent climbers (clusters 2 and 3) showed low range and variability of limb angular locations and coordination patterns. In particular, climbers of cluster 3 exhibited the lowest vertical displacement, the longest plateaux durations and the greatest ratio between tool swinging and definitive anchorage. Our results exemplified the positive influence of skills in rock climbing on ice climbing performance, facilitated by the detection of affordances from environmental properties.     

On the relative importance of linear model and human judge(s) in combined forecasting

When and to what extent should forecasts rely on linear model or human judgment? The judgmental forecasting literature suggests that aggregating model and judge using a simple 50:50 split tends to outperform the two inputs alone. However, current research disregards the important role that the structure of the task, judges’ level of expertise, and the number of individuals providing a forecasting judgment may play. Ninety-two music industry professionals and 88 postgraduate students were recruited in a field experiment to predict chart entry positions of pop music singles in the UK and Germany. The results of a lens model analysis show how task structure and domain-specific expertise moderate the relative importance of model and judge. The study also delineates an upper boundary to which aggregating multiple judgments in model-expert combinations adds predictive accuracy. It is suggested that ignoring the characteristics of task and/or judge may lead to suboptimal forecasting performance.     

Emotion work and job stressors and their effects on burnout

Abstract

This article reports research on emotion work, organizational as well as social variables as predictors of job burnout. In burnout research, high emotional demands resulting from interactions with clients are seen as a core characteristic of service jobs. However, these emotional demands were seldom measured in a direct manner. It was only recently that emotional demands were included in studies on burnout referring to the concept of emotion work (emotional labor). Emotion work is defined as the requirement to display organizationally desired emotions. A multi-dimensional concept of emotion work was used to analyze the relations of emotion work variables with organizational and social variables and their joint effect on burnout in five samples including employees working in children's homes, kindergartens, hotels, banks and call centers. Emotion work variables correlated with organizational stressors and resources. However, hierarchical multiple regression showed a unique contribution of emotion work variables in the prediction of burnout. Moreover, the analysis of interaction effects of emotional dissonance and organizational and social stressors showed that for service professionals, the coincidence of these stressors led to exaggerated levels of emotional exhaustion and depersonalization.     

Toward a Psychology of Religion, Spirituality, Meaning-Search, and Aging: Past Research and a Practical Application

The current work is a combined review of several major theoretical issues in religious gerontology and of related research findings. It is intended to briefly inform, rather than to serve as a comprehensive review of the literature. The current author's primary goals are to put-forth points of information about contemporary terminology, to conceptualize motives for meaning-search at any age, to synthesize a few major findings and associated flaws in the research, and to describe a practical approach to the psychology of religion and spirituality (i.e., coping outcomes research). Within the current work, the reader is directed to sources of extensive reviews of data and of broader theoretical debates.