The influence of playing a non-reward game on motor ability and executive function in Parkinson's disease

The aim of this study is to evaluate the acute effect of playing games on executive function and motor ability in Parkinson's disease (PD). Consecutive cases with PD were studied with the Unified Parkinson Disease Rating Scale (UPDRS), Mini-Mental State examination (MMSE), Beck Depression Inventory (BDI), Stroop test, finger tapping and 14-meter walk test. After randomization, patients performed a game of dominoes and were tested before and after experiment being further categorized as control, winners or non-winners. Forty patients, 27 male (67.5%), aged 48 to 84 years (63.2 ± 8.5), Hoehn & Yahr I to III were included. Twenty-eight (70%) presented depressive symptoms (BDI > 10). Groups (Control N = 13; Winners = 14 and Non-winners = 13) were not different regarding age, disease duration, age at onset, BMI, MMSE scores, depressive symptoms, levodopa dose, and previous practice of games. Winners presented significantly better results on executive function (Stroop test, p = 0.002) and on motor activity (Finger tapping, p = 0.01). Non-winners showed a trend of better performance in the 14-meter-walk test. This study shows that the practice of a non-reward game acutely improved memory and motor skills in PD. Our results suggest a role for the reward system in the modulation of the dopaminergic function of the basal ganglia in these patients.     

Examination of the Relationship Between PTSD and Distress Tolerance in a Sample of Male Veterans With Comorbid Substance Use Disorders

Distress tolerance (DT), the perceived or actual ability to tolerate negative emotional or physical states, is inversely related to posttraumatic stress disorder (PTSD) symptoms in civilian, community samples. No studies to date have examined the relationship between DT and PTSD in clinical samples of veterans with a comorbid diagnosis of PTSD and a substance use disorder (SUD). Thus, the present study examined the relationship between DT and PTSD in a sample of predominately African American, male veterans (n = 75) diagnosed with comorbid PTSD and SUD (according to a structured clinical interview). Results of hierarchical linear regression models indicated that DT was inversely related to total PTSD symptom severity score, above and beyond depressive symptoms and SUD severity. Of the 4 symptom clusters, DT was inversely associated with intrusions and hyperarousal. These findings are discussed in light of previous work with civilian samples. Determining whether treatment incorporating DT skills would be useful for veterans undergoing PTSD treatment should be evaluated.     

McEwen-Induced Modulation of Endocrine History: A Partial Review

In endless facets of physiology, there are points of homeostatic balance, such that too much or too litttle of something can both be deleterious (i.e., an "inverse U" pattern). This is particularly true when considering glucocorticoids (GCs), the adrenals steroid secreted during stress. In the first part of this paper, I review a number of realms in which a paucity and an excess of GCs are both damaging. Some findings are classical (for example, concerning GC effects upon body weight), while some are quite recent and have considerable implications for both physiology and pathophysiology (for example, inverse U's of GC actions in the realm of immunity and neuronal survival). The second part of the review considers the far thornier issue of how such inverse U's of GC actions are generated on a cellular and molecular level. One solution that has evolved, primarily in the hippocampus within the nervous system, involves the presence of two different types of receptors for GCs within the same cells; so long as the two receptors have very different affinities and mediate opposing effects on some cellular endpoint, an inverse U will emerge. The second solution, found in a number of peripheral tissues, involves GCs having opposing effects on the amount of some signal being generated (e.g., an immune cytokine) and the sensitivity of target tissues to that signal; under conditions that appear to be physiologically relevant, inverse U's emerge from this pattern as well. The final section of this review considers the enormous role played by Bruce McEwen in the emergence of this literature. I suggest that while much of this obviously has to do with the facts that have come from his group, another substantial contribution is from his steadying and supportive personality, the veritable embodiment of homeostatic balance.     

Color modulates olfactory learning in honeybees by an occasion-setting mechanism

A sophisticated form of nonelemental learning is provided by occasion setting. In this paradigm, animals learn to disambiguate an uncertain conditioned stimulus using alternative stimuli that do not enter into direct association with the unconditioned stimulus. For instance, animals may learn to discriminate odor rewarded from odor nonrewarded trials if these two situations are indicated by different colors that do not themselves become associated with the reward. Despite a growing interest in nonelemental learning in insects, no study has so far attempted to study occasion setting in restrained honeybees, although this would allow direct access to the neural basis of nonelemental learning. Here we asked whether colors can modulate olfactory conditioning of the proboscis extension reflex (PER) via an occasion-setting mechanism. We show that intact, harnessed bees are not capable of learning a direct association between color and sucrose. Despite this incapacity, bees solved an occasion-setting discrimination in which colors set the occasion for appropriate responding to an odor that was rewarded or nonrewarded depending on the color. We therefore provide the first controlled demonstration of bimodal (color-odor) occasion setting in harnessed honeybees, which opens the door for studying the neural basis of such bimodal, nonelemental discriminations in insects.     

Psychometric properties of the Social Skills Questionnaire: Portuguese adaptation of the student form (grades 7 to 12)

The present study aims to analyze the psychometric properties of the student form (Grades 7 to 12) of the Social Skills Questionnaire authored by Gresham and Elliott (1990), on a sample of Portuguese adolescents. Participants included 573 students, both female and male, aged 14 to 19. Reliability was assessed through Cronbach's alpha and was .87 for the total scale, ranging from.58 to .72 for the subscales. A confirmatory factor analysis revealed that the main adjustment indices presented unexpected values. A principal components analysis indicated that several items of the cooperation subscale correlated with other factors. Adequate adjustment indices were found when cooperation was removed from the model. Semantic dualities due to cultural factors and difficulties assuming the cooperation dimension as an independent dimension might explain the results observed. The reorganization of the SSQ offers a reliable and valid instrument for research within the Portuguese population.     

Perceived neighborhood environments and physical activity in an elderly sample

Increasing evidence indicates the importance of environmental variables in explaining physical activity. This study evaluated sex differences in perception of home and neighborhood environmental support and assessed which neighborhood environmental variables were associated with reported physical activity of elderly people. A sample of 126 women (M age = 79.1 +/- 6.6 yr.) and 55 men (M age = 76.6 +/- 7.7 yr.) were healthy, community-dwelling individuals. A questionnaire about environmental variables was administered. Physical activity was assessed on the Baecke Questionnaire. Logistic regression analysis showed that Neighborhood Safety was related to total physical activity, activity in leisure time, and sport activities. Men were also likely to be more active in leisure time than women. Neighborhood Personal Safety was associated with physical activity of these elderly people, showing a potential influence of the environmental domain in physical activity.     

Parenting Styles and Suicidal Ideation in Adolescents: Mediating Effect of Attachment

The present study aims to analyze the role of parenting styles in the development of suicidal ideation in adolescents, as well as test the mediating role of attachment to parents in the association between authoritative, authoritarian and permissive parenting style and suicidal ideation. The sample was made up of 604 individuals, aged between 15 and 18. In order to gather data, the Styles & Dimensions Questionnaire: Short Version, the Father/Mother Attachment Questionnaire and the Suicidal Ideation Questionnaire were used. The results suggest that the relations with parents, which are characterized by inhibition of exploration and of individuality, contribute to an emotional maladjustment being positively associated with suicidal ideation (r?=?.26 to r?=?.28). This confirmed the mediating role of parental attachment in the association between authoritative and permissive parenting styles from father and mother to suicidal ideation. It was also verified also a partial mediation, through the attachment to parents, in the association between the parent’s authoritarian style and the mother’s permissive styles and suicidal ideation. Furthermore, it was found the presence of total mediation, by throughout to attachment to the father, in the association between the father’s permissive style and suicidal ideation. The results suggest the importance of adopting authoritative parenting styles, since they seem to facilitate the development of the quality of attachment with parents. The results were analyzed in light of the attachment theory, taking into consideration the importance of parenting styles in understanding the processes inherent to suicidal ideation in adolescence.     

Personality differences between alcohol abusers and matched controls: Relation to frontal symptoms and subtypes of addicts

Epidemiological studies usually show a link between personality disorders and addictions. Dimensional models of personality, such as that of Cloninger, are able to diagnose and discriminate between transient dysfunctional behavior styles and relatively more stable traits. Certain brain areas have been proposed, as trait locations, based on their activation. This paper explores differences in personality traits among a sample of alcohol abusers (N= 95) and a control group of non-clinical population (N= 95), matched in sociodemographic variables, using the TCI-R-67 and the FrSBe-Sp. It is hypothesized that such differences are associated with frontal symptomatology. The existence of different subgroups of addicts based on certain combinations of traits is also analyzed. Results showed significant differences in two temperament traits (Novelty Seeking and Harm Avoidance) and a characterial trait (Self-Direction). We also found a correlation with a large effect size between these traits and frontal symptomatology. Cluster analysis classified the participants into several subtypes with different combinations of traits that matched diverse frontal symptomatology. Possible neurobiological explanations of these differences and their importance in the clinical practice are discussed.     

Developmental and sex-related differences in preschoolers' affective decision making

This study investigated developmental and sex-related differences in affective decision making, using a two-deck version of Children's Gambling Task administered to 3- and 4-year-old children. The main findings were that 4-year-old children displayed better decision-making performance than 3-year-olds. This effect was independent of developmental changes in inductive reasoning, language, and working memory. There were also sex differences in decision-making performance, which were apparent only in 3-year-old children and favored girls. Moreover, age predicted awareness of task and the correlation between the latter and decision-making performance was significant, but only in 4-year-old children. This study thus indicates that there is a remarkable developmental leap in affective decision making, whose effects are apparent around the age of 4, which according to our results, also marks the age when the correlation of declarative knowledge and decision-making performance becomes significant.     

Cultivating the Senses and Giving in to the Sacred: Notes on Body and Experience among Pentecostal Women in Salvador,Brazil

The article deals with the religious experience of poor Pentecostal women from the city of Salvador, Northeast Brazil. In centering the discussion of this experience on bodily engagement in place—and on the body's attunement to place—this article seeks to capture the social and existential dimensions of the sensibilities which women develop as members of the religious community and thus to address the question of how the sense experiences, which are awakened and cultivated in this religious setting, help shape embodied forms of attention to oneself, to others, and to context. We contend that concrete embodied experience of divine power fostered in ritual favors training attention to context in search of signs of divine presence and helps give shape to a disposition which extends, to other people and places, the power that flows from Pentecostal women's bodies.