Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

Differential induction of c-Jun and Fos-like proteins in rat hippocampus and dorsal striatum after training in two water maze tasks

Research examining the neuroanatomical bases of memory in mammals suggests that the hippocampus and dorsal striatum are parts of independent memory systems that mediate "cognitive" and stimulus-response "habit" memory, respectively. At the molecular level, increasing evidence indicates a role for immediate early gene (IEG) expression in memory formation. The present experiment examined whether acquisition of cognitive and habit memory result in differential patterns of IEG protein product expression in these two brain structures. Adult male Long-Evans rats were trained in either a hippocampal-dependent spatial water maze task, or a dorsal striatal-dependent cued water maze task. Ninety minutes after task acquisition, brains were removed and processed for immunocytochemical procedures, and the number of cells expressing Fos-like immunoreactivity (Fos-like-IR) and c-Jun-IR in sections from the dorsal hippocampus and the dorsal striatum were counted. In the dorsal hippocampus of rats trained in the spatial task, there were significantly more c-Jun-IR pyramidal cells in the CA1 and CA3 regions, relative to rats that had acquired the cued task, yoked controls (free-swim), or na?ve (home cage) rats. Relative to rats receiving cued task training and control conditions, increases in Fos-like IR were also observed in the CA1 region of rats trained in the spatial task. In rats that had acquired the cued task, patches of c-Jun-IR were observed in the posteroventral striatum; no such patches were evident in rats trained in the spatial task, yoked-control rats, or na?ve rats. The results demonstrate that IEG protein product expression is up-regulated in a task-dependent and brain structure-specific manner shortly after acquisition of cognitive and habit memory tasks.     

Changes in adolescent response patterns on the MMPI/MMPI--a across four decades

The purpose of this study was to explore changes in adolescent self-presentation on the Minnesota Multiphasic Personality Inventory (MMPI; Hathaway & McKinley, 1940) and MMPI-A (Butcher et al., 1992) over a 40-year period. The primary samples used for comparison in this study include 1,235 adolescents, age 14 through 16, derived from the MMPI-A normative sample (Butcher et al., 1992) collected in 1989 and 10,514 adolescents, age 14 through 16, collected in 1948 and 1954 from Hathaway and Monachesi's (1963) study of adolescent personality and behavior. MMPI basic scale and item-level data were also included for 817 adolescents, age 14 through 16, collected by Colligan and Offord (1992) in 1985 as a further comparison. Between-sample analyses at the profile level revealed that adolescents from the MMPI-A normative sample scored significantly higher across basic clinical scales and lower on validity scales L and K than adolescents from the Hathaway and Monachesi (1963) sample, with mean data from the Colligan and Offord (1992) sample typically falling at a midpoint value. Analyses of Harris-Lingoes (Harris & Lingoes, 1955) subscale and item-level data were conducted to provide refined definitions of the contents of scale-level changes. Results were interpreted as reflecting moderate to large changes in response frequencies between eras of data collection, and emphasis was placed on the relatively high frequency of item endorsements by contemporary adolescents in the clinical direction in the MMPI-A normative sample. A series of cautions and limitations are also offered in interpreting these patterns.     

There is more to anger coping than "in" or "out"

There is growing dissatisfaction with a dichotomized "anger-in" versus "anger-out" view of anger coping. Three studies using student and community adultsamples revealed a broader understanding of the nature of anger coping styles and led to the development of the new Behavioral Anger Response Questionnaire (BARQ). The BARQ is empirically derived and factorially validated and has good psychometrics. Results suggest that dichotomizing anger responses as "in" versus "out" is too coarse and that a 6-factor model may be more appropriate. The 6 factors identified here are Direct Anger-Out, Assertion, Support-Seeking, Diffusion, Avoidance, and Rumination. Women reported use of a wider range of anger coping styles, especially more social support-seeking and more use of anger diffusion strategies than men.     

Examining mental health symptoms in male and female incarcerated juveniles

Varying risk factors for both incarceration and mental health diagnoses have been identified for female juveniles, highlighting the need for gender-specific assessments and treatment protocols. The purpose of this study is to determine how the prevalence rates of mental health symptoms differ in male and female juvenile offenders. It was hypothesized that the prevalence rates would be greater for females than males. This study found significant differences between males and females on several clinical scales. These findings are consistent with past studies that have identified differences in mental health symptoms between genders.     

You’re Better Respected When You Carry Yourself as a Man: Black Men’s Personal Accounts of the Down Low “lifestyle”

Although the notion of a down low life style, called various things at various times, has a long history in the black community, the past few years have been marked by an exponential increase in attention of this phenomenon in both the mainstream press and scholarly work. However, much of this work has focused on exploring whether men on the down low present a unique threat for HIV infection to black women. Currently, there exist very few scholarly works exploring the lives of black men who have sex with men and women that specifically address their own experiences living on the down low or how these men personally define what it means to be on the down low. In this article, we explore why black men who have sex with men and black men who have sex with men and women, including those who self-identify as gay, bisexual or as being on the down low, come to use the down low label and what it means to them to be on the down low.     

Clergy work-related satisfactions in parochial ministry: The influence of personality and churchmanship

The aim of this study was to test several hypotheses that clergy work-related satisfaction could be better explained by a multidimensional rather than a unidimensional model. A sample of 1071 male stipendiary parochial clergy in the Church of England completed the Clergy Role Inventory, together with the short-form Revised Eysenck Personality Questionnaire. Factor analysis of the Clergy Role Inventory identified five separate clergy roles: Religious Instruction, Administration, Statutory Duties (conducting marriages and funerals), Pastoral Care, and Role Extension (including extra-parochial activities). Respondents also provided an indication of their predispositions on the catholic–evangelical and liberal–conservative dimensions. The significant associations of the satisfactions derived from each of the roles with the demographic, personality, and churchmanship variables were numerous, varied, and, with few exceptions, small in magnitude. Separate hierarchical regressions for each of the five roles indicated that the proportion of total variance explained by churchmanship was, in general, at least as great as that explained by personality, and was greater for three roles: Religious Instruction, Statutory Duties, and Role Extension. It was concluded that clergy satisfactions derived from different roles are not uniform and that churchmanship is at least as important as personality in accounting for clergy work satisfaction.     

Skeptical theism,moral skepticism,and epistemic propriety

Respondents to the argument from evil who follow Michael Bergmann’s development of skeptical theism hold that our failure to determine God’s reasons for permitting evil does not disconfirm theism (i.e. render theism less probable on the evidence of evil than it would be if merely evaluated against our background knowledge) at all. They claim that such a thesis follows from the very plausible claim that (ST) we have no good reason to think our access to the realm of value is representative of the full realm of value. There are two interpretations of ST’s strength, the stronger of which leads skeptical theists into moral skepticism and the weaker of which fails to rebut the argument from evil. As I demonstrate, skeptical theists avoid the charge of moral skepticism while also successfully rebutting the argument from evil only by embracing an equivocation between these two interpretations of ST. Thus, as I argue, skeptical theists are caught in a troubling dilemma: they must choose between moral skepticism and failure to adequately respond to the argument from evil.