A case of persistent neurogenic stuttering following a missile wound

Observational criteria that have been proposed to distinguish developmental from neurogenic stuttering are critically reviewed. It is concluded that both conditions may closely resemble each other. As an example, a case of neurogenic stuttering following a missile would is reported.     

Inhibition of the LH Surge by Restraint Stress in Cyclic Rats: Studies on the Role of GABAA and GABAB Receptors

There is evidence that stress can alter the activity in the brain of gamma-aminobutyricacid (GABA), a neurotransmitter that has been implicated in the regulation of LH secretion. In the present study the role of GABA in the restraint stress-induced inhibition of the LH surge was investigated in the intact cyclic rat. Intracerebroventricular (icv) administration of the GABAA receptor agonist muscimol (0.1, 0.5 or 1 μg) 5 min before the presumed onset of the pro-oestrous LH surge (at 0900 h) caused a dose dependent suppression of the surge. A single dose of the GABAB receptor agonist baclofen (1 μg; icv) injected at 0855 h postponed the onset of the LH surge, and repeated injections at 0855 and 1130 h suppressed the surge. These data indicate that GABA-ergic activity in the brain can inhibit the LH surge in the cyclic rat via GABAA and GABAB receptors. Pro-oestrous rats were subjected to 5 hrs of restraint starting at 0855 h. Pretreatment with the GABAA receptor antagonist bicuculine (1 μg; icv) at 0840, 0940 and 1040 h or pretreatment with the GABAB receptor antagonist phaclofen (10 μg; icv) at 0840 h were ineffective in preventing the restraint-induced inhibition of the LH surge. The results suggest that GABAA and GABAB receptors are not involved in the inhibitory effect of restraint stress on the LH surge.     

Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

Stop—reaction time and the internal clock

In astop-reaction-time (stop-RT) task, a subject is presented with a regular, isochronous sequence of brief signals separated by a constant time interval, orstimulus onset asynchrony (SOA). His/her task is to press a response key as fast as possible when the sequence stops. As the sequence unfolds, an internal representation of the SOA duration builds up. Stop-RT is assumed to be triggered when aninternal clock, operating as an “alarm clock,” reaches a time criterion. Criterion setting is contingent upon variability in the SOA’s internal representation. In Experiment 1A, stop-RT was measured for isochronous sequences of brief tones, light flashes, and also sequences of tones and flashes presented in regular alternation (tone-light-tone…). Stop-RT was a linear function of SOA duration (ranging from 250 to 1,000 msec), regardless of modality, supporting a “central-clock” hypothesis. On the other hand, taken together, the results of Experiments 1A, 1B, 2, and 3 suggest that no internal representation of thebimodal (tone-light) SOA of alternating sequences builds up. Indeed, an alternating sequence is physically equivalent to two interlaced isochronous subsequences, one auditory and one visual. So,two internal representations, one for the auditory (tone-tone) and one for the visual (light-light) SOA, could build up, andtwo time criteria running “in parallel” could thus support stop-RT. To provide a critical test of parallel timing, stop-RT was measured for bimodal 5∶3 polyrhythms formed by the superposition of auditory and visual isochronous sequences that haddifferent SOA durations (Experiment 4). Parallel timing accounted for a large proportion of variance in polyrhythmic stop-RT data. Overall findings can be accounted for by assuming a functional architecture of an internal clock in which pulses emitted by acentral pacemaker are available in parallel with twomodality-specific switch-accumulator “timing modules.”     

Judging the relative duration of multimodal short empty time intervals

Three experiments address the cause of the different performance levels found in time discrimination of empty intervals with durations near 250 msec. Performance differed according to the kind of sensory modality that marked the intervals. With a procedure in which the type of marker was randomized from trial to trial, it was shown that variability of discrimination judgments could not be attributed entirely to the variability of the criterion on which a judgment was based. Such a randomization slightly affects discrimination but provokes a reorganization related to marker conditions of the probabilities of judging an interval to be short or long. Moreover, it was shown that within intramodal conditions, physical characteristics of markers influence the discrimination performances. To account for the results generated with different marker-type intervals at 250 msec, we propose that two types of processor may be involved in duration discrimination: one is specifically related to a given sensory modality, whereas the other is aspecific and responsible for discrimination of intermodal intervals.     

Scholastic achievement of adolescent refugees from Cambodia and Central America

This study investigated the relationship of emotional disturbance and pre- and postmigration environment to the scholastic achievement of adolescent refugees of very different cultural backgrounds. One hundred fifty-two Central American and Cambodian students in six Canadian high schools, as well as their parents, were interviewed to assess the students' emotional problems (using the Youth Self-Report and Child Behavior Checklist) and to determine the pre- and postmigration family environment. The findings indicated that the relationship between the emotional problems and scholastic achievement of teenaged refugees was tenuous. It was concluded that a connection between young refugees' symptomatology and their functional capacity should not be assumed. Nonetheless, certain pre- and postmigration variables, particularly trauma experienced in the homeland, seem to be associated with the academic achievement of some refugees.     

A pilot study of an intervention for breast cancer survivors and their spouses

Recent studies have shown that interventions that increase breast cancer patients' communication with family members lead to reduced patient distress. In this article, we report on a treatment development and pilot study of an intervention for couples coping with breast cancer. In phase 1 of this study, 10 couples participated in two focus groups that generated ideas and themes for the intervention. In phase 2, we developed and pilot tested our intervention with 48 couples: 12 in a 2-session format, 21 in a 1-session format, and 15 in a non-experimental control group. Our response rate shows that breast cancer patients and spouses were willing to participate and that treatment providers were willing to refer patients and their spouses. The 2-session format showed the most promise for producing positive change in mental health functioning and cancer-related stress.     

Validity and Reliability of the French Versions of the Body Shape Questionnaire

The validity of the 34-item and shortened versions of the Body Shape Questionnaire (BSQ) has been evaluated in various languages. To date, only the validity of the 34-item French BSQ scale has been tested in a nonclinical sample. This study assessed the reliability and validity of the 34-item French BSQ and 7 shortened versions in clinical and nonclinical samples. The 34-item French BSQ was administered to 159 obese women with and without binge eating disorders and to 1,169 female undergraduate students. The results suggested that the BSQ–8B was the best French BSQ to use in nonclinical and clinical samples.     

Immobility reaction at birth in newborn infant

Objective

To describe an immobility reaction (IR) that was not previously reported at or immediately after birth in human newborns.

Method

We analyzed 31 videos of normal term vaginal deliveries recorded from Time 0 of birth defined as the as the moment that lies between the birth of the thorax and the pelvis of the infant. We searched for perinatal factors associated with newborn's IR.

Results

IR at birth was observed in 8 of the 31 newborns. The main features of their behavior were immobilization, frozen face, shallow breathing and bradycardia. One of the 8 newborns had sudden collapse 2 h after birth. We found significant relationships between maternal prenatal stress (PS) and IR (p = .037), and a close to significant one between infants’ lividness at Time 0 and IR (p = .053). The first breath of the 31 newborns occurred before and was not associated with the first cry (p < .001).

Discussion

The main features of IR at birth are similar to those of the universal most severe response to severe stress or danger. The relationship with PS suggests that children who had IR at birth might be at risk for similar disorders as those associated with PS. Sudden neonatal collapse of one of the IR newborns needs further research to determine if they are at risk for sudden infant death syndrome.

Conclusion

This first report of an IR reaction at birth in human infants could open up new paths for improving early neonatal care. Further research is needed for maternal PS, stress hormones, umbilical cord blood pH measurements in IR newborns. The challenge of education and support for parents of IR newborns is outlined.     

A SYSTEMS MODEL OF SPIRITUALITY

Within the scientific study of spirituality there are substantial ambiguities and uncertainties about relevant concepts, terms, evidences, methods, and relationships. Different disciplinary approaches reveal or emphasize different aspects of spirituality, such as outcomes, behaviors, skills, ambitions, and beliefs. I argue that these aspects interdepend in a way that constitutes a “systems model of spirituality.” This model enables a more holistic understanding of the nature of spirituality, and suggests a new definition that disambiguates spirituality from related concepts such as religion, cultural sophistication, and prosocial behavior in animals. It also exposes important open questions about the nature of spirituality. To support the emerging scientific approach to the study of spirituality, I propose the development of a “philosophy of spirituality” that can clarify the conceptual terrain, identify important research directions, and facilitate a comprehensive and interdisciplinary investigation into the nature, validity, and implications of spirituality's conceptual and practical entailments.