A rational approach to rational suicide.

Suicide is a reaction to internal and external sources of stress and the impact of life events. In the elderly these situations are prevalent in many who are not suicidal and instead choose life. They represent what may be called rational nonsuicide. They are far more frequent than rational suicide. Nevertheless, considerably more is written about rational suicide than its alternative. The reasons for this phenomenon are reviewed, and suggestions are made for a rational approach to the affirmation of life rather than its rejection, even to the very end.     

Imagery, encoding specificity, and prose recall in 6-year-old children

Partial pictures depict only selected portions of prose passages. Partial pictures hypothetically aid retention by inducing young children to generate imagery for nonpictured prose. Results from two hundred eighty-eight 6-year-old children indicated that (a) partial pictures at study facilitate recall, (b) identical study and retrieval prompts facilitate recall, and (c) imagery instructions and training do not affect retention. Partial pictures apparently help children to encode information more efficiently at study, but there is no evidence that young children generate images with the aid of the partial picture cues, nor that they have a retrieval deficit for these images as suggested by M. Ruch and J. Levin.     

The effect of standard, motivation, and strategy instructions on the facial processing accuracy of internal and external subjects

In the present study, it was hypothesized that poorer performance of externals in cognitive and interpersonal tasks also would be found in the processing of nonverbal information in the form of a facial affect recognition task. It was further hypothesized that the poorer nonverbal processing performance of externals was due to either their lower motivation or their use of less effective processing strategies. Subjects (N = 70) were divided into internal and external groups and then further subdivided into groups that received standard, motivational, or strategy instructions. Analysis of subjects' responses to the facial affect recognition task showed internals performed significantly better than externals under standard conditions. However, neither motivational nor strategy instructions improved the performance of externals. The implications for interpersonal functioning of the poorer nonverbal processing ability of extenrals was discussed from both theoretical and methodological perspectives.     

Spontaneous alternation behavior in animals: A review

Factors affecting spontaneous alternation behavior (SAB) in animals, for example, age, gender and species studied; type of apparatus and cues employed; and neuro-anatomical, neuro-chemical and motivational status of the organism, were reviewed. Despite a myriad of experiments showing interesting main effects of such variables, little research has been performed assessing the interactive affects of these factors on alternation behavior. For example, psychologists test rats in central nervous system (CNS) lesion studies, whereas psychopharmacologists tend to assess SAB in mice. Most importantly, studies have not been reported investigating the possible interactions among species, brain lesions and drugs. This is an unfortunate omission since several important alternation models include propositions relating to cholinergic and/or serotonergic coding in the hippocampus. Examination of behavioral studies revealed the primary cue for alternation among invertebrates to be body turn, whereas vertebrates rely primarily on directional and odor cues. Reference to the seeking of stimulus change remains the most compelling motivational account of why animals manifest this ubiquitious and reliable behavior pattern. This review and the unpublished studies were supported by Research Grants MH16962, MH21288, and MH36491 from the National Institute of Mental Health and the Wake Forest University Research and Publication Fund.     

Inhibition of the LH Surge by Restraint Stress in Cyclic Rats: Studies on the Role of GABAA and GABAB Receptors

There is evidence that stress can alter the activity in the brain of gamma-aminobutyricacid (GABA), a neurotransmitter that has been implicated in the regulation of LH secretion. In the present study the role of GABA in the restraint stress-induced inhibition of the LH surge was investigated in the intact cyclic rat. Intracerebroventricular (icv) administration of the GABAA receptor agonist muscimol (0.1, 0.5 or 1 μg) 5 min before the presumed onset of the pro-oestrous LH surge (at 0900 h) caused a dose dependent suppression of the surge. A single dose of the GABAB receptor agonist baclofen (1 μg; icv) injected at 0855 h postponed the onset of the LH surge, and repeated injections at 0855 and 1130 h suppressed the surge. These data indicate that GABA-ergic activity in the brain can inhibit the LH surge in the cyclic rat via GABAA and GABAB receptors. Pro-oestrous rats were subjected to 5 hrs of restraint starting at 0855 h. Pretreatment with the GABAA receptor antagonist bicuculine (1 μg; icv) at 0840, 0940 and 1040 h or pretreatment with the GABAB receptor antagonist phaclofen (10 μg; icv) at 0840 h were ineffective in preventing the restraint-induced inhibition of the LH surge. The results suggest that GABAA and GABAB receptors are not involved in the inhibitory effect of restraint stress on the LH surge.     

Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

CHOICE-MAKING TREATMENT OF YOUNG CHILDREN'S SEVERE BEHAVIOR PROBLEMS

The choice-making behavior of 5 young children with developmental disabilities who engaged in aberrant behavior was studied within a concurrent operants framework. Experimental analyses were conducted to identify reinforcers that maintained aberrant behavior, and functional communication training packages were implemented to teach the participants to gain reinforcement using mands. Next, a choice-making analysis, in which the participants chose one of two responses (either a mand or an alternative neutral response) to obtain different durations and qualities of reinforcement, was conducted. Finally, treatment packages involving choice making via manding were implemented to decrease inappropriate behavior and to increase mands. The results extended previous applications of choice making to severe behavior disorders and across behaviors maintained by positive and negative reinforcement.     

A comparison of multiple reinforcer assessments to identify the function of maladaptive behavior

Functional analysis results indicated that maladaptive behaviors displayed by a 25-year-old man with profound mental retardation were maintained by attention from caregivers and possibly, to a lesser degree, by access to tangible items. A concurrent-schedules procedure was then used to study the relative reinforcing value for maladaptive behavior of attention versus tangible items. Results of the concurrent-schedules assessment and subsequent functional communication training indicated that preference for attention versus access to a tangible object varied.