Sex-related difference in amygdala activity during emotionally influenced memory storage

We tested the possibility suggested by previous imaging studies that amygdala participation in the storage of emotionally influenced memory is differentially lateralized in men and women. Male and female subjects received two PET scans for regional cerebral glucose-one while viewing a series of emotionally provocative (negative) films, and a second while viewing a series of matched, but emotionally more neutral, films. Consistent with suggestions from several previously published studies, enhanced activity of the right, but not the left, amygdala in men was related to enhanced memory for the emotional films. Conversely, enhanced activity of the left, but not the right, amygdala in women was related to enhanced memory for the emotional films. These results demonstrate a clear gender-related lateralization of amygdala involvement in emotionally influenced memory, and indicate that theories of the neurobiology of emotionally influenced memory must begin to account for the influence of gender.     

Use of a common software system for collaborative clinical research on attentional processes in schizophrenia and ADHD

MacArthur Network III, consisting of five nodes (locations) and over 100 investigators, was formed in 1983 to conduct collaborative clinical research on risk and protective factors associated with psychiatric disorders. The common measurement of attentional dysfunction associated with two specific disorders (schizophrenia and attention deficit-hyperactivity disorder) was a goal of a subgroup of 11 Network III investigators. In this paper, the experiences with five approaches for implementing common protocols on laboratory computers for collaborative clinical research are described. The reasons for selecting the approach provided by Schneider’s (1988) MEL system are presented and discussed.