Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

Relations of Tripartite Dimensions of Emotion to Childhood Anxiety and Mood Disorders

This study examined preliminary higher-order models relating tripartite dimensions of emotion to severity of anxiety and depressive disorders in 100 clinically referred children and adolescents. In light of the accumulating support for multifactor models of vulnerability and negative emotion in children, the present investigation was designed to establish preliminary estimates of the structure and magnitude of the relations of three emotion factors with dimensions of social anxiety, depression, panic, generalized anxiety, obsessions/compulsions, and separation anxiety. Results were consistent with structures that minimally specified two higher-order emotion factors, yet only some parameter estimates were consistent with theory regarding the tripartite model. Problems with the measurement of tripartite factors and possibilities for further research are outlined.     

Sex differences among five sources of motivation in the motivation sources inventory: preliminary findings

Paper reports sex differences among five sources of motivation for a sample of 208 undergraduate students who completed the Motivation Sources Inventory. t tests yielded few statistically significant sex differences for the five sources of motivation; however, Instrumental Motivation was higher among men than women, while the remaining four motives showed no sex difference. Implications and research opportunities are discussed.     

Understanding the effects of moving visual stimuli on unilateral neglect following stroke

Moving visual stimuli have been shown to reduce unilateral neglect (ULN), however, the mechanisms underlying these effects remain poorly understood. This study compared lateralised and non-lateralised moving visual stimuli to investigate whether the spatial characteristics or general alerting properties of moving visual stimuli are responsible for reducing neglect. Post-stroke left neglect patients as well as healthy and patient control subjects were tested on a computerised line bisection task under six visual stimulus conditions. The key finding was that, relative to the no stimulus condition, leftward moving and left-sided moving visual stimuli shifted neglect patients' bisection errors leftward while the non-lateralised random moving visual stimuli did not reduce neglect patients' rightward bisection errors. The results provide evidence that spatial characteristics rather than general alerting properties of moving visual stimuli reduce rightward bisection errors in ULN. Moreover, the pattern of findings strongly supports the notion that moving visual stimuli reduce neglect by capturing attention and drawing it to a spatial location rather than by activating the attentional system via superior collicular neurons.     

Therapist Grief and Functional Analytic Psychotherapy: Strategic Self-Disclosure of Personal Loss

Functional Analytic Psychotherapy (FAP), a behavioral approach that focuses on the development of genuine and meaningful therapeutic relationships including the strategic use of disclosure, provides a framework for therapist self-disclosure during times of personal loss. This article briefly outlines FAP and provides an example of FAP in practice following the death of the first author’s mother. Qualitative data from a client questionnaire on the impact of this disclosure are presented, which suggest that the disclosure was a positive experience for most but not all clients. The article concludes with clinical guidelines that can enhance therapeutic effectiveness whether or not therapists choose to disclose loss to their clients and general precautions for treading in this emotionally intense territory.     

Does Happiness Predict Medication Adherence among African Americans with Hypertension?

Poor medication adherence is a leading cause of excessive cardiovascular morbidity among African Americans. Many adherence-promoting interventions have addressed economic barriers, improved the patient-provider relationship, simplified regimens, and used reminder systems; however, the problem of low adherence remains intractable. Meanwhile, positive psychological attributes that might serve to promote medication adherence have not been fully explored. To address this gap, we examined the association between happiness and medication adherence among low-income African Americans with hypertension treated in a safety-net setting. Data were obtained from the Alabama Collaboration for Cardiovascular Equality, 2007?C2008. Happiness was measured using the 4-item scale of Lyubomirsky and Lepper; low, moderate, and high happiness were defined by tertiles because of the non-normal distribution. Medication adherence was assessed with the Morisky Medication Adherence Scale. Associations were quantified with ordinal logistic regression. Our sample of 573 African Americans was 71.6?% female and had an average age?±?SD of 53.6?±?9.7?years and a median happiness score of 5.2. Compared to participants with low happiness, the odds (OR; 95?% CI) of being in a better medication adherence category were greater for those with moderate (1.53; 1.02?C2.27) and high (2.26; 1.52-3.37) happiness, after adjusting for age, sex, income, education, and difficulty paying for medical care. Within this cohort of low-income African Americans with hypertension, participants with greater happiness exhibited better medication adherence. Although one interpretation of our study is that more adherent patients are naturally happier, our findings raise the possibility that adding happiness-boosting components may increase the effectiveness of more traditional adherence interventions.     

The effects of preparedness for suicide following the death of a young adult child

Suicide deaths are often viewed as sudden and unexpected. Research examining bereavement responses to suicide are generally set within this conceptual framework. Twenty-two parents were interviewed about their bereavement experience following the suicide death of a young adult son or daughter. Data analyzed using narrative methods revealed the concept of preparedness. Three distinct preparedness narratives were identified, termed turbulent-relief, tragedy, and reflective plots. The data presented here highlights the way in which these different situations influence the resultant grief. Understanding preparedness for suicide assists in explaining the variety of grief responses in parents bereaved in this manner.     

Well-being and Substance Use in Emerging Adulthood: The Role of Individual and Family Factors in Childhood and Adolescence

The present study examined the long-term impact of individual and family factors during childhood and adolescence on outcomes associated with the transition to adulthood, specifically well-being and substance use. Data for this study were drawn from the Child Development Supplement (CDS) and Transition to Adulthood (TA) surveys (n?=?1362), both a part of The Panel Study of Income Dynamics (PSID). We first examined the influence of individual and family factors from childhood and adolescence on well-being and substance use during the transition to adulthood using Structural Equation Modeling (SEM). We then applied a mixture modeling approach to evaluate whether there were subgroups (latent classes) in these transitions to adulthood outcomes, and how these subgroups linked with the individual and family factors from younger years. We found that, in general, parental acceptance and psychological control in childhood and adolescence predicted all aspects of well-being during the transition to adulthood. Substance use during this transition was linked with being male, White, and heightened parental psychological control. Overall, observable differential associations between individual and family factors during childhood and adolescence and outcomes in later life highlighted a need to evaluate transitional aspects independently, rather than grouping young adults all together.