Top-down strategy in rehabilitation of spatial neglect: how about age effect?

The aim of this work is to verify the effectiveness of our treatment in patients with spatial neglect in relation to their age and to the severity of neglect. Lots of studies on rehabilitation were proposed and, in some of them, treatments based upon visual-scanning abilities were described. Our rehabilitation training is aimed to induce patients to find by themselves an adequate strategy to solve spatial problems and, after that, try to let this searching strategy as automatized as possible. In this study, forty-six patients with right brain damage and left visuo-spatial neglect underwent to this specific cognitive treatment. A neuropsychological battery was administered before and after treatment. Repeated measure MANOVA on test performances showed significant main effects of treatments, age, and severity of neglect; an interaction effect between these three variables was found as well. Our results confirm an effectiveness of treatment, in particular for elderly patients. Actually, they seem to show a better recovery of neglect after cerebral stroke, even for those of them affected by a severe neglect. These data could be explained in accordance with recent neurophysiological models that claim compensatory responses to reduce brain plasticity even in terms of reorganization of cognitive functions such as visuo-spatial attention.     

Permanence and change in memory II. Reproduction of words in sentences

Abstract.— A retroactive interference paradigm was employed for studying qualitative memory changes. Sentences, containing an ambiguous word that was defined differently by succeeding words, were used as stimulus material. Such retroactive definitions of meaning were found to lead to qualitative changes in reproduction. It is suggested that the issue of permanence and change in memory may be related to the choice of lists of independent items or contextual units as stimulus material. A contextual theory of memory, implying the conception of memory in a stream, is advocated.     

Coordinate high-frequency pattern of stimulation and calcium levels control the induction of LTP in striatal cholinergic interneurons

Current evidence appoints a central role to cholinergic interneurons in modulating striatal function. Recently, a long-term potentiation (LTP) of synaptic transmission has been reported to occur in these neurons. The relationship between the pattern of cortico/thalamostriatal fibers stimulation, the consequent changes in the intracellular calcium concentration ([Ca2+]i), and the induction of synaptic plasticity was investigated in striatal cholinergic interneurons from a rat corticostriatal slice preparation by means of combined electrophysiological intracellular recordings and microfluorometric techniques. Different protocols of stimulation were considered, varying both the frequency and the duration of the train of stimuli. High-frequency stimulation (HFS) (three trains at 100 Hz for 3 sec, 20-sec interval) induced a rise in [Ca2+]i, exceeding by fivefold the resting level, and caused a LTP of synaptic transmission. Tetanic stimulation delivered at lower frequencies (5-30 Hz) failed to induce long-term changes of synaptic efficacy. The observed elevation in [Ca2+]i during HFS was primarily mediated by L-type high-voltage activated (HVA)-Ca2+ channels, as it was fully prevented by nifedipine. Conversely, blockade of NMDA and AMPA glutamate receptor did not affect either LTP or the magnitude of the [Ca2+]i rise. Interestingly, the pharmacological analysis of the post-tetanic depolarizing postsynaptic potential (DPSP) revealed that LTP was attributable, to a large extent, to the potentiation of the GABA(A)-mediated component. In conclusion, the expression of LTP in striatal cholinergic interneurons is a selective response to a precise stimulation pattern of induction requiring a critical rise in [Ca2+]i.     

Family Economic Well-Being,and (Class) Relative Wealth: An Empirical Analysis of Life Satisfaction of Secondary School Students in Three Italian Cities

The aim of the study is to shed light on an under-investigated topic—the determinants of life satisfaction of the young—by means of an econometric analysis which focuses specifically on the relationship between household wealth and life satisfaction of secondary school students living in three Italian cities: Rome, Milan and Genoa. We find that family home ownership, mortgages and (class) relative wealth significantly affect the life satisfaction of students. Other significant controls are geographical residence (those living in Milan are significantly less satisfied with life), the mother’s occupation, and trust in family and friendships. The characteristics of our household wealth variables make it hard to conceive any inverse causality (and endogeneity highly unlikely), thus suggesting a direct causality nexus for these factors. We explain why our research provides important insights that should be taken into account when developing policies to promote the subjective well-being of the young.     

How Discrimination Impacts Sociopolitical Behavior: A Multidimensional Perspective

The conventional wisdom regarding the impact of discrimination on political behavior is that the perception of prejudiced treatment motivates individuals to take political action. This study challenges this common conception by demonstrating that the source of discrimination can play a significant role in whether perceived or experienced injustice leads to activism or withdrawal from sociopolitical life. Drawing from political science and social psychology literature, this study provides a new perspective on the potential effects of discrimination on a relatively new marginalized group in the United States. Specifically, an important distinction is drawn between political (systematic) and societal (interpersonal) discrimination in analyzing the sociopolitical behavior of American Muslims in the aftermath of the 9/11 terrorist attacks. The results will hopefully encourage scholars to take a deeper look at the nexus between discrimination and democratic engagement, which is an important, complex, multidimensional, and understudied topic.     

A computer-controlled language training system for investigating the language skills of young apes

A computer-controlled language training system was designed and constructed to enhance the objectivity and efficiency of inquiry into the language-relevant behaviors of apes. The system allows the S to gain control over the events of the 24-h day in direct correspondence with its competence in using a keyboard on which each key represents a word. Various incentives can be obtained through the selection and depression of appropriate keys in accordance with rules of sentence structure monitored by a computer. The system is flexible and allows for eventual conversation between man and ape, with the computer as the intermediary. A Teletype records all that transpires. Achievements of the chimpanzee S over the course of the first 8 months of the system’s operation attest to the worth of the system and training methods.     

Eye movements and bisection behavior in spatial neglect syndrome: representational biases induced by the segment length and spatial dislocation of the stimulus

The present study explored behavioral and eye-movement measures in unilateral neglect patients in response to online bisection task (unfilled gap line). Two different tasks supported the bisection performance, a pointing and a grasping strategy. It was explored whether these different strategies may influence subjects' behavioral and eye-movement measures in response to different segment features: segment length (from shorter to longer) and segment spatial dislocation (from right to left spatial location). Consistent spatial biases were found for both bisection responses, fixation count, and duration, as well as for the first fixation count in case of pointing task. An "extreme-left" gradient effect was suggested and discussed, with patients' behavioral and eye measures more impaired. On the contrary, the patients' performance overlaps with the controls' one in case a grasping task. The direct link of visual pointing and grasping strategy, respectively, with the two cortical ventral and dorsal pathways was adduced to explain our results.     

Eye movements and bisection behavior in spatial neglect syndrome: representational biases induced by the segment length and spatial dislocation of the stimulus

The present study explored behavioral and eye-movement measures in unilateral neglect patients in response to online bisection task (unfilled gap line). Two different tasks supported the bisection performance, a pointing and a grasping strategy. It was explored whether these different strategies may influence subjects’ behavioral and eye-movement measures in response to different segment features: segment length (from shorter to longer) and segment spatial dislocation (from right to left spatial location). Consistent spatial biases were found for both bisection responses, fixation count, and duration, as well as for the first fixation count in case of pointing task. An “extreme-left” gradient effect was suggested and discussed, with patients’ behavioral and eye measures more impaired. On the contrary, the patients’ performance overlaps with the controls’ one in case a grasping task. The direct link of visual pointing and grasping strategy, respectively, with the two cortical ventral and dorsal pathways was adduced to explain our results.     

The assessment and management of suicide risk: state of workshop education

A systematic search of popular and scholarly databases identified workshops that addressed general clinical competence in the assessment or management of suicide risk, targeted mental health professionals, and had at least one peer-reviewed publication. We surveyed workshop developers and examined empirical articles associated with each workshop. The state of workshop education is characterized by presenting the learning objectives, educational formats, instructor factors, and evaluation studies. Workshops are efficacious for transferring knowledge and shifting attitudes; however, their role in improving clinical care and outcomes of suicidal patients has yet to be determined.