A Randomized, Double-Blind, Crossover Comparison of MK-0929 and Placebo in the Treatment of Adults With ADHD

Objective: Preclinical models, receptor localization, and genetic linkage data support the role of D4 receptors in the etiology of ADHD. This proof-of-concept study was designed to evaluate MK-0929, a selective D4 receptor antagonist as treatment for adult ADHD. Method: A randomized, double-blind, placebo-controlled, crossover study was conducted in adults with primary ADHD. The primary end point was changed from baseline in total score on the Adult ADHD Investigator Symptom Rating Scale following a 4-week treatment regimen. Additional measures included Clinical Global Impression-Severity Scale, Hospital Anxiety and Depression Scale, and Brown Attention Deficit Disorder Scale and D4 genotype analysis. Results: No statistically significant treatment differences were found between MK-0929 and placebo in any of the primary or secondary assessments. Conclusion: Results from this study suggest that blockade of the D4 receptor alone is not efficacious in the treatment of adult ADHD.     

Psychophysics with children: Investigating the effects of attentional lapses on threshold estimates

When assessing the perceptual abilities of children, researchers tend to use psychophysical techniques designed for use with adults. However, children’s poorer attentiveness might bias the threshold estimates obtained by these methods. Here, we obtained speed discrimination threshold estimates in 6- to 7-year-old children in UK Key Stage 1 (KS1), 7- to 9-year-old children in Key Stage 2 (KS2), and adults using three psychophysical procedures: QUEST, a 1-up 2-down Levitt staircase, and Method of Constant Stimuli (MCS). We estimated inattentiveness using responses to “easy” catch trials. As expected, children had higher threshold estimates and made more errors on catch trials than adults. Lower threshold estimates were obtained from psychometric functions fit to the data in the QUEST condition than the MCS and Levitt staircases, and the threshold estimates obtained when fitting a psychometric function to the QUEST data were also lower than when using the QUEST mode. This suggests that threshold estimates cannot be compared directly across methods. Differences between the procedures did not vary significantly with age group. Simulations indicated that inattentiveness biased threshold estimates particularly when threshold estimates were computed as the QUEST mode or the average of staircase reversals. In contrast, thresholds estimated by post-hoc psychometric function fitting were less biased by attentional lapses. Our results suggest that some psychophysical methods are more robust to attentiveness, which has important implications for assessing the perception of children and clinical groups.

     

Under the Corporate Radar: Examining Insider Business Cybercrime Victimization through an Application of Routine Activities Theory

ABSTRACT

Cybercrime is recognized as one of the top threats to UK economic security. On a daily basis, the computer networks of businesses suffer security breaches. A less explored dimension of this problem is cybercrimes committed by insiders. This paper provides a criminological analysis of corporate insider victimization. It begins by presenting reviews of insider criminal threats and routine activities theory as applied to cybercrime. Analysis of the nationally representative Cardiff University UK Business Cybercrime Survey then informs statistical models that predict the likelihood of businesses suffering insider cyber victimization, using routine activities and guardianship measures as predictors.     

Representational parts

Phenomenology and the Cognitive Sciences -     

Diagnostic Utility: Experimental Demonstrations and Replications of Powerful Question Effects in High‐Stakes Deception Detection

The concept of diagnostic utility was used to create questions that would differentially affect deception detection accuracy. Six deception detection studies show that subtle differences in questioning produced accuracy rates that were predictably, substantially, and reliably above and below chance. The first 3 detection studies demonstrate that diagnostically useful questioning can reliably achieve accuracy rates over 70% with student and experienced judges. The fourth and fifth experiments demonstrated negative diagnostic utility among federal investigators but not students. The final experiment crossed 3 sets of interview questions with experience. Strong question effects produced a swing in accuracy from 32 to 73%. A questioning by experience interaction was also obtained.     

The interference of various word parts on color naming in the Stroop test

This study compared the interfering effects of various word parts on performance of the Stroop task. In different conditions, the first, middle, and last two letters of a color word formed color patches. In other conditions, random letters were attached to these word parts. In a control condition, entire words formed the color patches. While no condition produced as much interference as the control condition, the first part of a color word interfered with color naming more than other word parts. The addition of unrelated letters had little or no effect on the interference produced by the first part of a word. The results are consistent with suggestions that word perception often involves the activation of an articulatory motor program which is initiated by the first part of the word.     

The ecology of eating: smaller portion sizes in France Than in the United States help explain the French paradox

Part of the "French paradox" can be explained by the fact that the French eat less than Americans. We document that French portion sizes are smaller in comparable restaurants, in the sizes of individual portions of foods (but not other items) in supermarkets, in portions specified in cookbooks, and in the prominence of "all you can eat" restaurants in dining guides. We also present data, from observations at McDonald's, that the French take longer to eat than Americans. Our results suggest that in the domain of eating, and more generally, more attention should be paid to ecological factors, even though their mechanism of operation is transparent, and hence less revealing of fundamental psychological processes. Ironically, although the French eat less than Americans, they seem to eat for a longer period of time, and hence have more food experience. The French can have their cake and eat it as well.