Age- and education-adjusted normative data for the Montreal Cognitive Assessment (MoCA) in older adults age 70–99

The original validation study for the Montreal Cognitive Assessment (MoCA) suggests a cutoff score of 26; however, this may be too stringent for older adults, particularly for those with less education. Given the rapidly increasing number of older adults and associated risk of dementia, this study aims to provide appropriate age- and education-adjusted norms for the MoCA. Data from 205 participants in an ongoing longevity study were used to derive normative data. Individuals were grouped based on age (70–79, 80–89, 90–99) and education level (≤12 Years, 13–15, ≥16 Years). There were significant differences between age and education groups with younger and more educated participants outperforming their counterparts. Forty-six percent of our sample scored below the suggested cutoff of 26. These normative data may provide a more accurate representation of MoCA performance in older adults for specific age and education stratifications.     

Semantic clustering as a neuropsychological predictor for amnestic-MCI

Recent research has demonstrated that patients with Alzheimer's disease (AD) show deficits in semantic processing when compared to cognitively healthy individuals. This difference is thought to be attributed to losses in higher cortical systems that are predominantly associated with executive functioning. The first aim of the study will be to determine if differences in semantic clustering can accurately differentiate patients with amnestic mild cognitive impairment (aMCI) from cognitively normal (CN) individuals. The second aim will be to determine the extent to which semantic processing might be associated with executive functions. Data from 202 (134 CN, 68 aMCI) participants were analyzed to quantify differences in semantic clustering ratios on the HVLT-R. Study participants ages ranged from 51 to 87 with education ranging from 6 to 20 years. ANCOVA revealed statistically significant differences on semantic clustering ratios (p < .001). Moderate correlations between semantic clustering Category Fluency Test (r = .45) were also found. Statistically significant group differences were also present on Trails-B and WAIS-R Digit Symbol performance (p < .001). Overall, these data indicate that deficits in semantic clustering are present in aMCI patients.     

Semantic clustering as a neuropsychological predictor for amnestic-MCI

ABSTRACT

Recent research has demonstrated that patients with Alzheimer's disease (AD) show deficits in semantic processing when compared to cognitively healthy individuals. This difference is thought to be attributed to losses in higher cortical systems that are predominantly associated with executive functioning. The first aim of the study will be to determine if differences in semantic clustering can accurately differentiate patients with amnestic mild cognitive impairment (aMCI) from cognitively normal (CN) individuals. The second aim will be to determine the extent to which semantic processing might be associated with executive functions. Data from 202 (134 CN, 68 aMCI) participants were analyzed to quantify differences in semantic clustering ratios on the HVLT-R. Study participants ages ranged from 51 to 87 with education ranging from 6 to 20 years. ANCOVA revealed statistically significant differences on semantic clustering ratios (p < .001). Moderate correlations between semantic clustering Category Fluency Test (r = .45) were also found. Statistically significant group differences were also present on Trails-B and WAIS-R Digit Symbol performance (p < .001). Overall, these data indicate that deficits in semantic clustering are present in aMCI patients.     

Neurobehavioral Correlates of Chronic Hepatitis C

Chronic infection with the hepatitis C virus is a major public health concern in the United States and worldwide, and persons with psychiatric histories are more likely to have chronic hepatitis C (CHC). Neurobehavioral consequences of CHC are common in all phases of the disease process and significantly contribute to morbidity. Antiviral treatment also is associated with neurobehavioral difficulties that can interfere with successful completion of treatment and result in fewer patients clearing the virus. Fatigue, depression, cognitive dysfunction, and anxiety are the most common neuropsychiatric symptoms reported by patients with CHC regardless of treatment status. Behavioral health care professionals can play a vital role in decreasing the personal and societal burden of CHC by being active members of the treatment team and by furthering knowledge of how to manage neurobehavioral correlates of CHC.     

Linking social axioms with indicators of positive interpersonal, social and environmental functioning in Iran: an exploratory study

Social axioms are people's general beliefs about how the world functions and always involve the relationship between two conceptual entities. Social axioms have been proposed as a construct that can be useful in helping researchers interpret cultures and explain people's behaviors in different cultural contexts. Despite the growth of studies on social axioms in various countries, no effort has been made so far to investigate specifically the relation between social axioms and indicators of interpersonal, social, and environmental functioning. To fill this gap, this exploratory study sought to examine the relation between social axioms and a set of variables indicating positive interpersonal, social, and environmental functioning (namely, gratitude, connectedness to nature, social participation, perspective-taking, and empathic concern) in a sample of 303 Iranian university students. Findings showed that reward for application, religiosity, and social complexity significantly predicted gratitude when sex was controlled for. Social complexity and reward for application significantly contributed to explaining the variance in connectedness to nature over and above sex. Social cynicism and social complexity also predicted perspective-taking significantly after controlling for sex. Social axioms were not successful in predicting social participation and empathic concern. Overall, it is possible to conclude that the findings support the utility of social axioms in predicting interpersonal, social, and environmental functioning. That is, generalized beliefs about oneself, the social and physical environment, or the spiritual world are associated with individuals' interpersonal, social, and environmental functioning in this Iranian sample.