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MM Roozendaal De Kruijf HF RJ Reuling A Threels JJ Swarts VM Wiegant JA Mattheij 《Stress (Amsterdam, Netherlands)》1997,1(4):241-248
There is evidence that stress can alter the activity in the brain of gamma-aminobutyricacid (GABA), a neurotransmitter that has been implicated in the regulation of LH secretion. In the present study the role of GABA in the restraint stress-induced inhibition of the LH surge was investigated in the intact cyclic rat. Intracerebroventricular (icv) administration of the GABAA receptor agonist muscimol (0.1, 0.5 or 1 μg) 5 min before the presumed onset of the pro-oestrous LH surge (at 0900 h) caused a dose dependent suppression of the surge. A single dose of the GABAB receptor agonist baclofen (1 μg; icv) injected at 0855 h postponed the onset of the LH surge, and repeated injections at 0855 and 1130 h suppressed the surge. These data indicate that GABA-ergic activity in the brain can inhibit the LH surge in the cyclic rat via GABAA and GABAB receptors. Pro-oestrous rats were subjected to 5 hrs of restraint starting at 0855 h. Pretreatment with the GABAA receptor antagonist bicuculine (1 μg; icv) at 0840, 0940 and 1040 h or pretreatment with the GABAB receptor antagonist phaclofen (10 μg; icv) at 0840 h were ineffective in preventing the restraint-induced inhibition of the LH surge. The results suggest that GABAA and GABAB receptors are not involved in the inhibitory effect of restraint stress on the LH surge. 相似文献
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Klein Velderman Mariska van Dommelen Paula Pannebakker Fieke D. Reijneveld Sijmen A. 《Journal of child and family studies》2022,31(4):1069-1078
Journal of Child and Family Studies - Worldwide, many children experience parental separation and divorce. This has a significant impact on their well-being, and emotional and behavioral... 相似文献
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The attentional blink (AB) is often attributed to resource limitations, but the nature of these resources is commonly underspecified.
Recent observations rule out access to short-term memory or storage capacity as limiting factors, but operation bottlenecks
are still an option. We considered the operation span of working memory (WM) as a possible factor and investigated the relationship
between individual WM operation span (as measured by OSPAN), fluid intelligence (as measures by Raven’s SPM), and the size
of the AB. WM operation span was negatively correlated with the AB, whereas fluid intelligence was associated with higher
overall accuracy but not with AB magnitude. These results support the idea that individual processing limitations (with regard
to either attentional allocation policies or the speed of global cortical integration processes) play a key role in the AB. 相似文献
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