Combination pharmacotherapy in alcoholism: a novel treatment approach

Combination pharmacotherapy has proven effective in a number of psychiatric disorders, including depression and schizophrenia. However, compared with other affective disorders, few studies have explored the use of combination therapy in alcoholism, and the majority have been limited to animal models. There is evidence to support a role for combination therapy in alcoholism. For example, several neurochemical systems, including the dopaminergic, serotonergic, and opioidergic, appear to affect alcohol intake. Studies in several different types of alcohol-preferring rats have suggested that coadministration of agents to target more than one of these systems simultaneously may produce beneficial effects on alcohol intake, while avoiding problematic effects, such as alterations in food or water intake. Data from preliminary clinical studies have shown trends toward combination therapy reducing alcohol intake in humans. While such findings are encouraging, they must be explored further in larger, randomized, double-blind trials.     

Evidence for the Effectiveness of an Alternative Multisource Performance Rating Methodology

Despite persistent concerns as to the quality of performance information obtained from multisource performance ratings (MSPRs), little research has sought ways to improve the psychometric properties of MSPRs. Borrowing from past methodologies designed to improve performance ratings, we present a new method of presenting items in MSPRs, frame‐of‐reference scales (FORS), and test the efficacy of this method in a field and lab study. The field study used confirmatory factor analysis to compare the FORS to traditional rating scales and revealed that FORS are associated with increased variance due to dimensions, decreased overlap among dimensions, and decreased error. The laboratory study compared rating accuracy associated with FORS relative to frame‐of‐reference training (FORT) and a control group and demonstrated that FORS are associated with higher levels of accuracy than the control group and similar levels of accuracy as FORT. Implications for the design and implementation of FORS are discussed.     

Grief and trauma intervention for children after disaster: exploring coping skills versus trauma narration

This study evaluated the differential effects of the Grief and Trauma Intervention (GTI) with coping skills and trauma narrative processing (CN) and coping skills only (C). Seventy African American children (6-12 years old) were randomly assigned to GTI-CN or GTI-C. Both treatments consisted of a manualized 11-session intervention and a parent meeting. Measures of trauma exposure, posttraumatic stress symptoms, depression, traumatic grief, global distress, social support, and parent reported behavioral problems were administered at pre, post, 3 and 12 months post intervention. In general, children in both treatment groups demonstrated significant improvements in distress related symptoms and social support, which, with the exception of externalizing symptoms for GTI-C, were maintained up to 12 months post intervention. Results suggest that building coping skills without the structured trauma narrative may be a viable intervention to achieve symptom relief in children experiencing trauma-related distress. However, it may be that highly distressed children experience more symptom relief with coping skills plus narrative processing than with coping skills alone. More research on the differential effects of coping skills and trauma narration on child distress and adaptive functioning outcomes is needed.     

Item and order information in semantic memory: students’ retention of the “CU fight song” lyrics

University of Colorado (CU) students were tested on memory for the “CU Fight Song” in order to examine serial position effects in semantic memory while controlling for familiarity across positions. In Experiment 1, students reconstructed the order of the nine lines of the song. Students with previous exposure to the song performed better and showed a more bowed serial position function than did students with no knowledge of the song. Experiment 2 added a task assessing memory of item information. One word was removed and replaced with a blank in each line, and an alternative word was offered as an option, along with the correct word. Students selected the word that fit into each blank and then reconstructed the order of the lines. There was a bow-shaped curve for order reconstruction, but not for item selection, which implies that the serial position function in semantic memory stems from order, rather than item, information.     

Viewing the MMPI–2–RF Structure Through the Personality Psychopathology Five (PSY–5) Lens

Ben-Porath and Tellegen (2008) recommend organizing MMPI–2–RF scale interpretive information around 3 broad topics, emotional/internalizing dysfunction, thought dysfunction, and externalizing/behavioral dysfunction, and 3 additional topics labeled somatic complaints, interpersonal functioning, and interests. That organization is based primarily on structural analyses of the Restructured Clinical (RC) scales. This study reviewed the MMPI–2–RF's scale structure when the Personality Psychopathology Five (PSY–5) scales are included. Principal axis factor analyses with oblique rotation were conducted on the Restructured Clinical, PSY–5, and Special Problem (SP) scales in 2 samples, by gender. One sample was an outpatient community health center, the other a large, metropolitan inpatient psychiatric facility. The 6-factor solution evidenced each of the PSY–5 constructs plus a general somatic concerns factor. Implications of this solution in comparison to the 3-factor organizing structure recommended by Ben-Porath and Tellegen are discussed.     

The effect of induced anxiety on cognition: threat of shock enhances aversive processing in healthy individuals

Individuals with anxiety disorders demonstrate altered cognitive performance including (1) cognitive biases towards negative stimuli (affective biases) and (2) increased cognitive rigidity (e.g., impaired conflict adaptation) on affective Stroop tasks. Threat of electric shock is frequently used to induce anxiety in healthy individuals, but the extent to which this manipulation mimics the cognitive impairment seen in anxiety disorders is unclear. In this study, 31 healthy individuals completed an affective Stroop task under safe and threat-of-shock conditions. We showed that threat (1) enhanced aversive processing and abolished a positive affective bias but (2) had no effect on conflict adaptation. Threat of shock thus partially models the effects of anxiety disorders on affective Stroop tasks. We suggest that the affective state of anxiety—which is common to both threat and anxiety disorders—modulates the neural inhibition of subcortical aversive processing, whilst pathologies unique to anxiety disorders modulate conflict adaptation.