Alternative scoring system of repeated items on the MMPI: caveat emptor

There are 16 items in the standard MMPI group forms which are included twice. It was found that a number of computerized scoring services use only the first occurrence of repeated items in scoring the MMPI scales, whereas the handscoring templates use an arbitrary combination of the first and second occurrence of these items. Comparison of these conventions suggested a potential for significant differences in score, particularly on the Sc scale. Scoring a set of 126 MMPIs of chronic pain patients by both of these scoring conventions revealed differences of up to 10 T points on the Sc scale. It is recommended that a single scoring convention for the MMPI be adopted by psychologists. For several reasons we suggest that only the first occurrence of repeated items should be used for scoring purposes. In the absence of a single convention, comparisons between Sc scores on different protocols should not be made without first insuring that the protocols were scored in the same manner.     

The effect of mood and incentives on helping: Are there some things money can't buy?

Happy, guilty, and neutral mood states were induced in participants who were then provided with an opportunity to donate blood for free, to donate in exchange for $5, or to choose between donating for free or for $5. As expected, there was a significantly higher incidence of helping when subjects felt happy and guilty as opposed to emotively neutral. Contrary to predictions, helping was unaffected by the type of incentive (donate for $5, donate for free, choose $5/free) subjects were offered in interaction with their mood state. However, the type of incentive did seem to influence the postdonation emotions of subjects: Guilty subjects who donated for money felt significantly less guilty following donation than prior to it and happy subjects felt more self-altruistic (kind and generous) following donation when they helped for free. The results are discussed in terms of Cialdini's negative state relief model (for negative moods) and the intrinsic qualities of helping (for positive moods).     

Combination pharmacotherapy in alcoholism: a novel treatment approach

Combination pharmacotherapy has proven effective in a number of psychiatric disorders, including depression and schizophrenia. However, compared with other affective disorders, few studies have explored the use of combination therapy in alcoholism, and the majority have been limited to animal models. There is evidence to support a role for combination therapy in alcoholism. For example, several neurochemical systems, including the dopaminergic, serotonergic, and opioidergic, appear to affect alcohol intake. Studies in several different types of alcohol-preferring rats have suggested that coadministration of agents to target more than one of these systems simultaneously may produce beneficial effects on alcohol intake, while avoiding problematic effects, such as alterations in food or water intake. Data from preliminary clinical studies have shown trends toward combination therapy reducing alcohol intake in humans. While such findings are encouraging, they must be explored further in larger, randomized, double-blind trials.     

Reading aloud and the question of intent

Must readers intend to process a word to activate various levels of representation, or is such processing simply triggered by the presentation of a word (i.e., is it “automatic”)? This issue was addressed via the use of Besner and Care’s Task Set paradigm. On each trial a cue, which indicated which of two tasks to perform appeared either before the target, or at the same time as the target. If subjects can process the target while preparing a task set, then the effect of a manipulated psycholinguistic factor should be absorbed into the time taken to process the cue. Despite robust main effects of SOA and word frequency there was no interaction between these factors when the task was to read aloud. This result implies that target processing is delayed until the subject knows what task to perform, and therefore that intention plays an important role when reading words aloud.     

Lexical processing while deciding what task to perform: reading aloud in the context of the task set paradigm

The results of two experiments provide the first direct demonstration that subjects can process a word lexically despite concurrently being engaged in decoding a task cue telling them which of two tasks to perform. These results, taken together with others, point to qualitative differences between the mind‘s ability to engage in lexical versus sublexical processing during the time they are engaged with other tasks. The emerging picture is one in which some form of resource(s) plays little role during lexical processing whereas the need for some form of resource(s) during sublexical processing serves to bottleneck performance.     

Intervention,integration and translation in obesity research: Genetic,developmental and metaorganismal approaches

Obesity is the focus of multiple lines of inquiry that have -- together and separately -- produced many deep insights into the physiology of weight gain and maintenance. We examine three such streams of research and show how they are oriented to obesity intervention through multilevel integrated approaches. The first research programme is concerned with the genetics and biochemistry of fat production, and it links metabolism, physiology, endocrinology and neurochemistry. The second account of obesity is developmental and draws together epigenetic and environmental explanations that can be embedded in an evolutionary framework. The third line of research focuses on the role of gut microbes in the production of obesity, and how microbial activities interact with host genetics, development and metabolism. These interwoven explanatory strategies are driven by an orientation to intervention, both for experimental and therapeutic outcomes. We connect the integrative and intervention-oriented aspects of obesity research through a discussion of translation, broadening the concept to capture the dynamic, iterative processes of scientific practice and therapy development. This system-oriented analysis of obesity research expands the philosophical scrutiny of contemporary developments in the biosciences and biomedicine, and has the potential to enrich philosophy of science and medicine.     

The study of socioethical issues in systems biology

Systems biology is the rapidly growing and heavily funded successor science to genomics. Its mission is to integrate extensive bodies of molecular data into a detailed mathematical understanding of all life processes, with an ultimate view to their prediction and control. Despite its high profile and widespread practice, there has so far been almost no bioethical attention paid to systems biology and its potential social consequences. We outline some of systems biology's most important socioethical issues by contrasting the concept of systems as dynamic processes against the common static interpretation of genomes. New issues arise around systems biology's capacities for in silico testing, changing cultural understandings of life, synthetic biology, and commercialization. We advocate an interdisciplinary and interactive approach that integrates social and philosophical analysis and engages closely with the science. Overall, we argue that systems biology socioethics could stimulate new ways of thinking about socioethical studies of life sciences.