Attenuation of Hippocampal 11beta-Hydroxysteroid Dehydrogenase Type 1 by Chronic Psychosocial Stress in the Tree Shrew

11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) catalyses the interconversion of active cortisol and corticosterone with inert cortisone and 11-dehydrocorticosterone, thus regulating glucocorticoid access to intracellular receptors. In rats, chronic glucocorticoid excess or stress increases 11beta-HSD-1 in the hippocampus, producing suggestions that it may attenuate the deleterious effects of chronic glucocorticoid excess. However, 11beta-HSD-1 predominantly catalyses 11beta-reduction in the intact liver and hippocampal cells, thus regenerating active glucocorticoids from inert substrate. We studied 11beta-HSD activity in the tissues of male tree shrews following 28 days of sustained psychosocial stress or exogenous administration of cortisol. In the hippocampus, chronic psychosocial stress attenuated 11-HSD-1 activity (69 +/- 9% of control), whereas cortisol alone had no effect. In the liver, both chronic stress and cortisol administration decreased 11beta-HSD-1 activity (47 +/- 11% and 49 +/- 4% fall, resp.). Attenuation of 11beta-HSD-1 within tissues may reflect a homeostatic mechanism designed to minimise the adverse effects of prolonged stress and/or glucocorticoid excess.     

Repetition blindness reveals differences between the representations of manipulable and nonmanipulable objects

We used repetition blindness to investigate the nature of the representations underlying identification of manipulable objects. Observers named objects presented in rapid serial visual presentation streams containing either manipulable or nonmanipulable objects. In half the streams, 1 object was repeated. Overall accuracy was lower when streams contained 2 different manipulable objects than when they contained only nonmanipulable objects or a single manipulable object. In addition, nonmanipulable objects induced repetition blindness, whereas manipulable objects were associated with a repetition advantage. These findings suggest that motor information plays a direct role in object identification. Manipulable objects are vulnerable to interference from other objects associated with conflicting motor programs, but they show better individuation of repeated objects associated with the same action. (PsycINFO Database Record (c) 2012 APA, all rights reserved).     

The efficacy of noncontingent escape for decreasing children's disruptive behavior during restorative dental treatment

We evaluated the effectiveness of a dentist-implemented behavioral intervention in which brief escape from dental treatment was provided on a regular basis, independent of the child's behavior. Within a multiple baseline design across subjects, 5 children, ages 4 to 7 years, were provided with temporary escape from dental treatment on a fixed-time schedule. The intervals were signaled by an electronic timer worn by the dentist. Clinically significant reductions were observed in physically disruptive behavior across all 5 children with the introduction of noncontingent escape, and verbally disruptive behavior was markedly reduced in 4 of the 5 children. In addition, the dental staff s use of physical restraint was reduced to near zero across all 5 children. The research extends the literature in both clinical dentistry and in applied behavior analysis by demonstrating that a dentist can easily and effectively implement noncontingent reinforcement to produce clinically significant and socially important changes in children's health behavior.     

Quantitative analysis of human movement synergies: constructive pattern analysis for gait

To record three-dimensional coordinates of the joints from normal human subjects during locomotion, we used a digital motion analysis system (ELITE). Recordings were obtained under several different conditions, which included normal walking and stepping over obstacles. Principal component analysis was used to analyze coordinate data after conversion of the data to segmental angles. This technique gave a stable summary of the redundancy in gait kinematic data in the form of reduced variables (principal components). By modeling the shapes of the phase plots of reduced variables (distortion analysis) and using a limited number of model parameters, good resolution was obtained between subtly different conditions. Hence, it was possible to accurately resolve small distributed changes in gait patterns within subjects. These methods seem particularly suited to longitudinal studies in which relevant movement features are not known a priori. Assumptions and neurophysiological applications are discussed.     

Pseudosex in Pseudotheology

John Beaumont has attempted to revitalize the official RomanCatholic position against the use of artificial contraceptionby reinvigorating the argument against such from natural law.Maintaining that sexual acts are essentially reproductive acts,he holds that the use of contraceptives by married couples reducesintercourse to the same moral level as homosexual acts. He furtherargues that acceptance of birth control has directly led tothe legitimization of homosexual acts in American society. However,his analysis fails to distinguish between historical connectionsbetween the various elements of the sexual revolution and deepmoral relationships. His dependency on the natural law traditionalso results in an impoverished theological vision, which failsto relate human sexuality and the unitive drive to the divineimage in mankind. Only an anthropology which takes account ofthe Holy Trinity as the paradigm for human being can adequatelyground sexuality. This theological context, which is suppliedin the Eastern Orthodox tradition, grounds human sexuality ininterpersonal communion in love. It finds in the unitive drivethe need to realize the fullness of humanity in this experienceof communion, which directly reflects the Trinitarian natureof God. From such a perspective, the moral equation of maritalacts to homosexual indulgences is revealed as a gross distortion.Furthermore, the moral gulf that Beaumont seeks to establishbetween natural family planning and the use of contraceptivescollapses, as does the usefulness of natural law tradition ingeneral to combat the secularization of human sexuality.     

Dynamic interplay of depression,perfectionism and self-regulation on procrastination

This study aimed at investigating the intercorrelation among affective, cognitive and behavioural components on procrastination. A total of 402 undergraduate students (115 males, 286 females, 1 not indicated) participated in the study. Students completed the General Procrastination Scale, Depression, Anxiety and Stress Scale, Frost Multidimensional Perfectionism Scale and Self-regulation Inventory. A constructed hypothesised model was tested by utilising path analysis. Overall, the analysis indicated that the model sufficiently explained the data. The findings showed the multicorrelation among the variables, ranging from 14 to 58. Squared multiple correlation coefficients (R²) of procrastination revealed that endogenous and mediator variables explained 33% of the total variance in procrastination. The results demonstrated the importance of affect, cognition and behaviour on problematic delay referred to as procrastination.