非小细胞肺癌 EG FR 基因突变检测与临床意义

采用荧光PCR法对199例晚期非小细胞肺癌（NSCLC ）组织进行表皮生长因子受体（EGFR ）基因突变检测,分析EGFR基因突变的分布特征及其与临床病理特征的相关性。结果显示56例（28．1％）存在EGFR基因突变,其中27例（13．6％）为外显子19突变,25例（12．6％）为外显子21突变,2例为外显子18突变,1例外显子20突变,1例外显子18和20的共突变。另外,除广东及安徽省铜陵市外,辽宁地区NSCLC患者EGFR基因突变率及主要突变类型与其他地区相符,常见于外显子19、21突变,其中腺癌、不吸烟患者突变率更高,更适宜EGFR-TKI靶向治疗。     

Paid Work and Domestic Labor in Disadvantaged Communities on the Outskirts of Beirut, Lebanon

This article explored the association between economic activity and the contribution to domestic labor in a Middle Eastern society. Analyses were carried out on cross-sectional survey data from 5,998 individuals, aged between 18 and 64 years, in three poor communities in the suburbs of Beirut, Lebanon. Domestic labor was evaluated with a composite index that takes into account both the type of task performed and the level of involvement. Housework categories included core household chores, care giving, financial management, home management, and home/car maintenance. Results showed that women continue to do most of the domestic labor in the three communities. However, women’s load of domestic labor decreased as they joined the labor market, whereas men’s contribution to domestic labor increased with involvement in paid work. Relatively speaking, the difference in contribution to housework between house members engaged and not engaged in paid labor was much higher for women than it was for men.     

各种传统医学在高血压治疗中的应用

高血压痛作为最常见的慢性病,其并发症具有较高的致残率及致死率。本文综述近年来各种传统医学在高血压病治疗中的应用,包括传统中医对高血压痛的病因机的阐述,应用中药内服、外服、针灸等临床效果观察,蒙医辨证分型论治高血压病;藏医对高血压病的认识及临床采用的金针疗法治疗高血压病;壮医特色壮药内服,壮医药线点灸刺血疗法对高血压病的临床疗效评价。以此说明传统医药治疗方法对改善高血压病症状较明显,其治疗手段多样,副作用较小,降压效果平稳持久,有效减少并发症的优势。     

Profiles of dyadic adjustment for advanced prostate cancer to inform couple-based intervention

Objective: The purpose of the study is to describe from a relational perspective, partners’ psychological adjustment, coping and support needs for advanced prostate cancer.

Design: A mixed methods design was adopted, employing triangulation of qualitative and quantitative data, to produce dyadic profiles of adjustment for six couples recruited from the urology clinics of local hospitals in Tasmania, Australia.

Methods: Dyads completed a video-taped communication task, semi-structured interview and standardised self-report questionnaires.

Results: Themes identified were associated with the dyadic challenges of the disease experience (e.g. relationship intimacy, disease progression and carer burden). Couples with poor psychological adjustment profiles had both clinical and global locus of distress, treatment side-effects, carer burden and poor general health. Resilient couples demonstrated relationship closeness and adaptive cognitive and behavioural coping strategies. The themes informed the adaption of an effective program for couples coping with women’s cancers (CanCOPE, to create a program for couples facing advanced prostate cancer (ProCOPE-Adv).

Conclusion: Mixed method results inform the development of psychological therapy components for couples coping with advanced prostate cancer. The concomitance of co-morbid health problems may have implications for access and engagement for older adult populations in face-to-face intervention.     

DEMOGRAPHIC, PSYCHOLOGICAL, AND RELATIONSHIP FACTORS IN DOMESTIC VIOLENCE DURING PREGNANCY IN A SAMPLE OF LOW-INCOME WOMEN OF COLOR

Research suggests that a significant number of women first experience domestic violence during pregnancy. The current study examines correlates of violence during pregnancy, first by comparing women who did and did not report violence, and second examining three subgroups of women who reported violence (violence initiated, violence persisted, violence ceased). Results indicated that controlling for demographics, more frequent violence was associated with less support and satisfaction with support from the baby's father, more negative interactions with the baby's father, and more verbal aggression in their relationships than those who did not report violence. Differences among subgroups of women reporting violence emerged only for the relationship variables. Implications for detecting violence in clinical settings are discussed.