Forms of memory failure in schizophrenia.

Effortful and automatic memory task performances were examined in 36 schizophrenic patients and 18 normal control Ss. Tasks included free recall, recognition, and frequency estimation. Patients demonstrated impairment in recall, in recognition, in semantic encoding, and in frequency estimation. Deficits were observed across tasks despite differences in attentional demands. The results suggest a basic compromise of memory function, which is consistent with recent neuroimaging evidence of structural or physiological abnormalities in frontal and temporal lobe structures in schizophrenia.     

Improving performance and increasing the use of non-positive testing in a rule-discovery task

A well-documented characteristic of rule discovery behaviour is subjects' infrequent use of negative testing. Previous attempts at increasing the use of negative testing have met with little success. In an evaluation task, we found that subjects appreciate the benefits of negative testing and disconfirmation (Kareev & Halberstadt, this issue). Further, when given the choice, subjects prefer to begin their inquiry by employing a reception mode of inquiry, and only later switch to a generative strategy (Halberstadt & Kareev, 1992). In the present study we had subjects solve two rule-discovery problems. For the training problem, 180 subjects were assigned either to the traditional generation mode, in which subjects had to generate number triplets, or to a reception mode, in which subjects were presented with number triplets by the experimenter. For the subsequent test problem both groups used the traditional generation mode. Results revealed that subjects trained by the reception mode were more likely to use non-positive tests and more likely to solve the second problem. Apparently, training under the less demanding reception mode enabled subjects to realize the potential relevance of nonpositive testing.     

Evaluating negative tests and refutations in a rule discovery task

Subjects participating in Wason's rule discovery task (1960) overwhelmingly try to confirm rather than refute their currently held hypothesis. Such a strategy is often inadequate and runs counter to the canons of scientific methodology. The present study was designed to investigate subjects' differential evaluation of test strategies and outcome. One-hundred and sixty students participated in two experiments in which they had to judge someone else's potential test items in Wason's task. Experiment 1 demonstrated that exposure to various histories has a mediating effect on the strength of the confirmation bias. In Experiment 2, subjects knew the researcher's rule and thus whether each proposed test item would lead to confirmation or refutation of the hypothesis under consideration. The preferred items were those that alerted the subject to an incorrect hypothesis (refutation) and those that turned out to be positive instances of the rule sought after, with the combination of the two (a negative test leading to refutation) being most highly evaluated.     

Avoidance learning facilitates temporal processing in the primary auditory cortex

The primary auditory cortex is now known to be involved in learning and memory, as well as auditory perception. For example, spectral tuning often shifts toward or to the frequency of the conditioned stimulus during associative learning. As previous research has focused on tonal frequency, less is known about how learning might alter temporal parameters of response in the auditory cortex. This study addressed the effects of learning on the fidelity of temporal processing. Adult male rats were trained to avoid shock that was signaled by an 8.0 kHz tone. A novel control group received non-contingent tone and shock with shock probability decreasing over days to match the reduced number of shocks received by the avoidance group as they mastered the task. An untrained (nai ve) group served as a baseline. Following training, neuronal responses to white noise and a broad spectrum of tones were determined across the primary auditory cortex in a terminal experiment with subjects under general anesthesia. Avoidance conditioning significantly improved the precision of spike-timing: the coefficient of variation of 1st spike latency was significantly reduced in avoidance animals compared to controls and nai ves, both for tones and for noise. Additionally, avoidance learning was accompanied by a reduction of the latency of peak response, by 2.0-2.5 ms relative to nai ves and approximately 1.0 ms relative to controls. The shock-matched controls also exhibited significantly shorter peak latency of response than nai ves, demonstrating the importance of this non-avoidance control. Plasticity of temporal processing showed no evidence of frequency specificity and developed independently of the non-temporal parameters magnitude of response, frequency tuning and neural threshold, none of which were facilitated. The facilitation of temporal processing suggests that avoidance learning may increase synaptic strength either within the auditory cortex, in the subcortical auditory system, or both.