Cognitive and motor development of infants coping with cancer: Longitudinal observations

The prognosis for infants diagnosed with cancer before the age of 12 months continues to be generally dismal. Consequently, these babies receive very aggressive treatment and regularly endure many events that cause distress. This study followed a cohort of six infants diagnosed with cancer from the onset of treatment utilizing repeated assessments of cognitive and motor development. The purpose of the study was to evaluate systematically the impact of stressful life events and the protective effects of parents' remaining with their children during repeated hospitalizations. Across lengthy and aggressive treatments with chemotherapy, these infants demonstrated no signs of developmental lags or abnormalities, and parents reported generally positive effects for their marriages when remaining in the hospital with their baby. Results are discussed within a framework of coping with stressful life events and the protective effects for infants associated with encouraging parents to remain with their sick children as much as possible during hospitalizations.     

The interaction effect of ad appeal and need for cognition on consumers' intentions to share viral advertisements

Viral advertising has become a popular form of persuasive communication to promote brands on social media. Extant research on viral advertising has focused mostly on evaluating content characteristics as drivers of virality, but very few studies have examined the potential influence of consumers' personality variables that affect their information processing and subsequent ad‐sharing behavior. By taking a consumer‐centric approach, two experimental studies were conducted to examine how consumer's need for cognition (NFC: high vs. low) interacts with message appeal (emotional vs. informational) used in the branded viral advertisements and extent of brand information (high vs. low brand prominence) present in the branded viral advertisement to influence consumers' intentions to share viral advertisements. As compared with low‐NFC individuals, high‐NFC individuals reported higher sharing intentions for viral ads that use informational appeal and also for an emotional viral ad where brand prominence is high. This finding is consistent with the elaboration likelihood model (ELM). Further, the results of these studies show an interesting finding that contradicts the existing understanding originating from ELM; that is, high‐NFC individuals reported higher sharing intentions for viral ads with an emotional appeal as compared with low‐NFC individuals, even when the brand prominence is low. Possible explanations and implications of the findings are discussed in this paper.     

Precipitation in a Cu–4Ti–2Be alloy

It is known that the binary Cu–2?wt.% Be alloy can be strengthened by ageing its supersaturated solution at 523?K. The increase in the strength arising from ageing is because of the formation of GP zones. The same level of strength is achieved by ageing the supersaturated solid solution of a dilute binary Cu–4?wt.% Ti alloy at 723?K. In contrast to Cu–2?wt.% Be alloy, the increase in strength in this alloy occurs on account of spinodal decomposition of the as-quenched microstructure through the mechanism of clustering and ordering. In the present study, decomposition of a supersaturated solid solution of the ternary Cu–4?wt.% Ti–2?wt.% Be alloy was studied. Whereas ageing of this alloy at 523?K resulted in the formation of GP zones like in a Cu–2?wt.% Be alloy, ageing at 723?K resulted in a spinodally decomposed microstructure as in a Cu–4?wt.% Ti alloy. The decomposition of the ternary alloy at the two temperatures by two different mechanisms indicates that Be and Ti in solution in Cu act, more or less, independently of each other during ageing.     

Manipulated flow reduces downstream defensiveness

Flow is a psychological state people experience when performing highly challenging tasks with a high degree of skill. It is related to happiness, creativity, and productivity. In three experiments, we developed a manipulation of flow and assessed its effects on subsequent defensive behavior. In all three experiments, participants who played a game with more features of flow (e.g. engagement, match of challenge and skill, performance feedback) reported more feelings of flow (e.g. enjoyment, concentration and interest) and less downstream defensiveness. The results suggest that we developed a flexible, reliable manipulation of flow, and that inducing people to experience flow may reduce their subsequent defensive behavior.     

Aerobic exercise in the psychological treatment of adolescents.

A small group of psychiatrically institutionalized adolescents (16 boys, 11 girls) were assigned to a three-day-per-week running/aerobic exercise program or a regular physical activity class. The complete program continued over 9 weeks, with 11 subjects remaining throughout the program. Dependent measures of body-mass index, timed performance on a one-mile run, resting, exercise, and recovery heart rates, and measures of depression, mood-states, and self-efficacy were assessed pre-, mid-, and post-9-wk. treatment and at a 4-wk. follow-up. Improvements in depression, anxiety, hostility, confused thinking, and fatigue were shown in treated girls, with increases in vigor and self-efficacy for all treated subjects.     

A comparison of EMG and SCL in normal and depressed subjects

Skin conductance level (SCL) and electromyograms (EMGs) recorded from three muscle sites were compared for 15 female hospitalized psychiatric patients meeting diagnostic criteria for primary affective disorder and 15 age- and race-matched controls. The depressed subjects had significantly lower SCL and significantly higher resting EMG levels recorded from one muscle site. Electromyogram and SCL were not found to be significantly correlated with each other or with measures of anxiety or depression for the patients with primary affective disorder. Normal controls, however, showed significant correlations between a measure of depression and both EMG and SCL. These results are discussed with suggestions for future research.     

Deliver us from evil? The temptation,realities, and neuroethico-legal issues of employing assessment neurotechnologies in public safety initiatives

In light of the recent events of terrorism and publicized cases of mass slayings and serial killings, there have been calls from the public and policy-makers alike for neuroscience and neurotechnology (neuroS/T) to be employed to intervene in ways that define and assess, if not prevent, such wanton acts of aggression and violence. Ongoing advancements in assessment neuroS/T have enabled heretofore unparalleled capabilities to evaluate the structure and function of the brain, yet each and all are constrained by certain technical and practical limitations. In this paper, we present an overview of the capabilities and constraints of current assessment neuroS/T, address neuro-ethical and legal issues fostered by the use and potential misuse of these approaches, and discuss how neuroethics may inform science and the law to guide right and sound applications of neuroS/T to “deliver us from evil” while not being led into temptations of ampliative claims and inapt use.     

The Processes of Scientific Discovery: The Strategy of Experimentation

Hans Krebs' discovery, in 1932, of the urea cycle was a major event in biochemistry. This article describes a program, KEKADA, which models the heuristics Hans Krebs used in this discovery. KEKADA reacts to surprises, formulates explanations, and carries out experiments in the same manner as the evidence in the form of laboratory notebooks and interviews indicates Hans Krebs did. Furthermore, we answer a number of questions about the nature of the heuristics used by Krebs, in particular: How domain-specific are the heuristics? To what extent are they idiosyncratic to Krebs? To what extent do they represent general strategies of problem-solving search? The relative generality of KEKADA allows us to view the control structure of KEKADA and its domain-independent heuristics as a model of scientific experimentation that should apply over a broad domain.     

Family Care Behaviors and Early Childhood Development in Low- and Middle-Income Countries

Epidemiological evidence linking early childhood development (ECD) with family care behaviors is limited. This study assessed relationships of ECD with family care behaviors and child nutritional status in 77,315 children 36–59 months from 26 low- and middle-income countries from the Multiple Cluster Indicator Surveys round 4. We used UNICEF-recommended indicators for literacy–numeracy and learning development. Family care behaviors measured were provision of books and play materials, inadequate care, activities of adult caregivers with child, father’s involvement, attendance to early childhood education program, and violent discipline. Nutritional status was measured by height-for-age z-scores. Three-level linear mixed-model regression analysis was done separately for each ECD outcome. Both developmental domains were associated with family care behaviors, with strongest associations between literacy–numeracy and program attendance, provision of books, and stimulating activities. Differences in the proportion on track for literacy–numeracy were 0.176–0.277 for these three family care behaviors. The multivariable model controlling for maternal education and wealth showed that children with provision of books, program attendance, and four stimulating activities had a proportion of being on track for literac–numeracy that was 0.427 higher than children without these. Higher height-for-age was associated with higher prevalence of being on track for literacy–numeracy and learning development. This study provides epidemiological evidence on the importance of family care behaviors for ECD. ECD could be substantially fostered by interventions that promote appropriate family care behaviors and resources for learning stimulation even in contexts of socioeconomic and educational disadvantage.