Benzodiazepine receptor ligand influences on acquisition: suggestion of an endogenous modulatory mechanism mediated by benzodiazepine receptors

In rats, pretraining ip administration of the central benzodiazepine receptor antagonist, flumazenil (5.0 mg/kg), or of the inverse agonist, n-butyl-beta-carboline-3-carboxylate (BCCB) (0.2 or 0.5 mg/kg), facilitated retention of a step-down inhibitory avoidance task; the central agonists, clonazepam and diazepam (0.4 or 1.0 mg/kg), had an opposite effect, and the peripheral agonist, 4'-chlordiazepam (1.25 or 6.25 mg/kg), was without effect. Pre- but not post-training flumazenil (2.0 mg/kg) blocked the effect of BCCB (0.5 mg/kg), clonazepam (1.0 mg/kg), or diazepam (1.0 mg/kg) given also pretraining. The post-training administration of all of these drugs had no effect on retention of the avoidance task. Flumazenil (5.0 mg/kg) and BCCB (0.5 mg/kg), given before training, enhanced retention test performance of habituation to a buzzer but not of habituation to an open field. In the three tasks studied, none of the drugs used had any appreciable effect on training session parameters. These results suggest that there is an endogenous mechanism mediated by benzodiazepine agonists, sensitive to inverse agonists, that normally down-regulates acquisition of certain behaviors; this mechanism becomes activated only when the tasks involve or occur with a certain degree of stress or anxiety (i.e., inhibitory avoidance or habituation to the buzzer) and not in less stressful or anxiogenic tasks (i.e., habituation to an open field).     

The effect of flumazenil on acquisition, retention, and retrieval of spatial information.

The effect of flumazenil, a benzodiazepine-receptor antagonist, was evaluated in a spatial-reference memory procedure in a water maze. Flumazenil (1.0, 3.0, and 10.0 mg/kg, ip) did not modify acquisition of spatial information. Retention was similar between control and experimental rats 24 h after the training phase, as all groups showed bias to the target quadrant in a free swim trial. However, 10 days later, only flumazenil-injected rats (3.0 mg/kg) showed bias to the target quadrant. Flumazenil did not affect retrieval of spatial information in a group of well-trained rats. These results suggest that a benzodiazepine-receptor mediated endogenous mechanism is activated during learning of spatial tasks and that its blockade facilitates retention of spatial information.     

The right place for me: A moderated mediation model to explain the involvement of employees aged over 50 years

Over the past decades, employment rates of older workers in most Western countries have rapidly increased. Hence, there is a growing interest in identifying the organizational dimensions that might impact the psychosocial adjustment of workers aged over 50 years. This study focuses on perceived organizational support (POS) and identity-related measures (identification and authenticity) as key organizational components for workers at this stage of life. Furthermore, in the relationships discussed, we explore the moderating role of perceived age discrimination. In an ample sample of older workers (N = 4,563, aged 50–66 years), a moderated mediational model was tested where older workers' involvement was associated to POS. In the model, this relationship was mediated by organizational identification and authenticity, and the association between POS, identity-related measures, and involvement was moderated by age-based discrimination. Results showed that POS is associated with organizational involvement via organizational identification and authenticity and that high level of age discrimination decreased the positive association between POS, organizational identification, authenticity, and involvement.     

Relationship between short- and long-term memory and short- and long-term extinction

Both the acquisition and the extinction of memories leave short- and long-term mnemonic traces. Here, we show that in male Wistar rats, the short-term memory for a step-down inhibitory avoidance task (IA) is resistant to extinction, and that its expression does not influence retrieval or extinction of long-term memory. It has been known for some time that short- and long-term inhibitory avoidance memory involve separate and parallel processes. Here we show that, instead, short-term extinction of IA long-term memory is the first step towards its long-term extinction, and that this link requires functional NMDA receptors and protein synthesis in the CA1 region of the dorsal hippocampus at the time of the first CS-no US presentation.     

Snitching versus reporting: A qualitative analysis of barriers and facilitators to addressing safety concerns among high school students

Social Psychology of Education - Creating effective school-wide safety mechanisms depends on understanding students' previous experiences of reporting, however, students may also be...     

Do Women Accommodate More Than Men? Gender Differences in Perceived Social Support and Negotiation Behavior by Spanish and Dutch Worker Representatives

Historically, the role of worker representatives (WRs) is traditionally perceived as masculine. With an increasing participation of women in the workforce, the number of female WRs grows all over Europe. WRs’ main task is to negotiate on behalf of the constituency. We explore how male and female WRs perceive support from their constituency and how this perceived support is related to their negotiation behavior. We test hypotheses about the impact of gender and societal culture on perceived support and accommodating behavior in negotiations. The hypotheses are tested using a quantitative approach among 219 female and 495 male WRs in Spain and 166 female and 398 male WRs in the Netherlands. Following the research question there was no evidence indicating gender differences in accommodating behavior. Results show that a) WRs accommodate less to management in Spain than in the Netherlands; b) female WRs perceive less social support than their male counterparts in Spain, but not in the Netherlands; c) social support is negatively related to accommodating behavior only for female WRs in Spain, but not in the Netherlands. We discuss theoretical and practical implications.     

The meanings of silence: Wittgensteinian contextualism and polyphony

Radical feminists have argued that there are normative exclusions that have silenced certain voices and have rendered certain meanings unintelligible. Some Wittgensteinians (including some Wittgensteinian feminists) have argued that these radical feminists fall into a philosophical illusion by appealing to the notions of 'intelligible nonsense' and 'inexpressible meanings', an illusion that calls for philosophical therapy. In this paper I diagnose and criticize the therapeutic dilemmathat results from this interpretation of Wittgenstein's contextualism. According to this dilemma, if something is meaningful, it must be expressible from the perspective of the participantin language-games; and if it is not so expressible, it is not meaningful at all. I argue that this is a false dilemma that rests on the untenable internalist notion of a unified 'participant's perspective'. I propose an alternative contextualist view that underscores the polyphonyof language-games, that is, the irreducible multiplicity of perspectives always present in discursive practices (if only implicitly and in embryo). Through a discussion of the different meanings of silence, my polyphonic contextualism tries to show that our linguistic practices always exhibit an irreducible diversity and heterogeneity of points of view that cannot be subsumed under a unified perspective.     

Aspectos metodológicos de la investigación experimental sobre la adquisición de la lectura

RESUMEN

En este trabajo se revisan algunos aspectos de la metodología de la investigación experimental cognitiva. Tras un breve análisis de ciertas cuestiones acerca de los sujetos, aparatos y estímulos, se propone una taxonomía de veinte tareas experimentales, incluyendo procedimientos relacionados con las primeras etapas del procesamiento y otros implicados en las propiedades del procesador central. Estas tareas están especialmente dedicadas a evaluar tres dimensiones cognitivas en el aprendizaje de la lectura: las subhabilidades de los procesos de codificación, el estado de las rutas de acceso al léxico y las propiedades del sistema cognitivo (tales como la velocidad y la precisión de las estrategias de procesamiento).     

Power and conflict in cooperative and competitive contexts

Power and conflict are classic research topics in organizational theory and important practical management issues. The goal of this article was to analyse the influence of supervisor power bases and goal interdependence situations over intragroup conflict. The study involved the participation of 401 workers from a range of social service organizations. Hierarchical regression analyses showed that (a) supervisor personal power bases were negatively associated with task and relationship conflict; (b) supervisor position power bases were positively associated with relationship conflict; (c) cooperative environments were negatively associated with task and relationship conflict; and (d) that goal interdependence moderates the negative consequences of the use of position power. The implications for research and managerial practices are discussed.