Failure of acute and chronic administration of Δ9-tetrahydrocannabinol to affect the repeated acquisition of serial position responses in pigeons

Pigeons were trained to acquire a new four-response position sequence each day by pecking three response keys in a predetermined order. The key color varied after each correct response prior to food delivery. Acute administration of Γ⁹-tetrahydrocannabinol (Δ⁹-THC) up to a dose that completely eliminated responding, had no effect on total acquisition errors, or on within session patterns of error elimination. Chronic administration of Δ⁹-THC (3–10 mg/kg/day), either before or after the session for 4–7 weeks, also did not affect these error measures, although rates of responding were markedly suppressed and at times no responding occurred Discontinuation of Δ⁹-THC administration for periods of 4–6 weeks also was without effect on errors. These experiments suggest that neither acute nor chronic Δ⁹-THC produce specific effects on the repeated acquisition of serial position responses in pigeons.     

Schedules using noxious stimuli. II: low intensity electric shock as a discriminative stimulus

The presence or absence of pulses of low intensity electric shock was used as a discriminative stimulus to control responding under fixed ratio reinforcement in the squirrel monkey. Initially brief periods of nonreinforcement were lengthened only when discriminative control was evident. Discriminative control was studied by (1) varying the duration of nonreinforcement periods; (2) reversing the stimulus conditions correlated with reinforcement and nonreinforcement periods; and (3) determining the minimum shock intensity necessary to maintain discriminative control. Stimulus control was not reliably affected by d-amphetamine, chlorpromazine, or morphine. The discriminative control by pulses of low intensity electric shock was similar to that by other discriminative stimuli, except that the control developed slowly and was better when the pulsing shock was correlated with reinforcement than when correlated with nonreinforcement.     

激活右腹外侧前额叶提高抑郁症患者对社会疼痛的情绪调节能力：一项TMS研究

负性人际交往经历和负性社会事件是抑郁症的重要诱导因素, 而社会功能受损是抑郁症患者的重要特征之一, 患者通常表现出对社会疼痛的情绪失调。为了提高抑郁症患者在负性社交情境中或面对负性社会事件时的情绪调节能力, 本研究采用经颅磁刺激技术(transcranial magnetic stimulation, TMS), 考察抑郁症患者在腹外侧前额叶(the ventrolateral prefrontal cortex, VLPFC)被激活后其情绪调节能力的改变。结果表明, 当右侧VLPFC被TMS激活且患者采用认知重评策略调节情绪时, 实验组患者(n = 64)比对照组患者(n = 63)在社会排斥情境下报告了更弱的负性情绪体验, 这说明激活右侧VLPFC可以有效提高患者对社会疼痛的外显性情绪调节能力。本研究是采用TMS提高抑郁症患者情绪调节能力的首次尝试, 实验发现不但支持了VLPFC与认知重评策略的因果关系, 还为临床改善抑郁症等社会功能障碍患者的情绪调节能力提供了明确的神经治疗靶点。后续研究还需探讨多疗程TMS刺激方案、改变社会疼痛的诱发方式、对比左右侧VLPFC的治疗效果、尝试使用其他的情绪调节策略, 进一步验证本研究的结论, 优化TMS治疗方案。     

Drug discrimination under concurrent variable-ratio variable-ratio schedules

Pigeons were trained to discriminate 5 mg/kg pentobarbital from saline under concurrent variable-ratio (VR) VR schedules, in which responses on the pentobarbital-biased lever were reinforced under the VR schedule with the smaller response requirements when pentobarbital was given before the session, and responses on the saline-biased key were reinforced under the VR schedule with the larger response requirements. When saline was administered before the session, the reinforcement contingencies associated with the two response keys were reversed. When responding stabilized under concurrent VR 20 VR 30, concurrent VR 10 VR 40, or concurrent VR 5 VR 50 schedules, pigeons responded almost exclusively on the key on which fewer responses were required to produce the reinforcer. When other doses of pentobarbital and other drugs were substituted for the training dose, low doses of all drugs produced responding on the saline-biased key. Higher doses of pentobarbital and chlordiazepoxide produced responding only on the pentobarbital-biased key, whereas higher doses of ethanol and phencyclidine produced responding only on this key less often. d-Amphetamine produced responding primarily on the saline-biased key. When drugs generalized to pentobarbital, the shape of the generalization curve under concurrent VR VR schedules was more often graded than quantal in shape. Thus, drug discrimination can be established under concurrent VR VR schedules, but the shapes of drug-discrimination dose-response curves under concurrent VR VR schedules more closely resemble those seen under interval schedules than those seen under fixed-ratio schedules. Graded dose-response curves under concurrent VR VR schedules may relate to probability matching and difficulty in discriminating differences in reinforcement frequency.     

Drug discrimination under a concurrent fixed-ratio fixed-ratio schedule.

Pigeons were trained to discriminate 5.0 mg/kg pentobarbital from saline under a two-key concurrent fixed-ratio 10 fixed-ratio 40 schedule of food presentation, in which the fixed-ratio component with the lower response requirement was programmed to reinforce responding on one key after drug administration (pentobarbital-biased key) and on the other key after saline administration (saline-biased key). After responding stabilized, pigeons averaged 98% of their responses on the pentobarbital-biased key during training sessions preceded by pentobarbital, and they averaged 90% of their responses on the saline-biased key during training sessions preceded by saline. In test sessions preceded by doses of pentobarbital, chlordiazepoxide, or ethanol, pigeons switched from responding on the saline-biased key at low doses to responding on the pentobarbital-biased key at higher doses (the dose-response curve was quantal). High doses of phencyclidine produced responding on both keys, whereas pigeons responded almost exclusively on the saline-biased key after all doses of methamphetamine. These and previous experiments using concurrent reinforcement schedules to study drug discrimination illustrate that the schedule of reinforcement is an important determinant of the shape of dose-effect curves in drug-discrimination experiments.     

浅谈口腔正畸学中临床思维与实践技能的并重

口腔正畸学对临床思维和实践技能均有较高的要求.在口腔正畸医生的成长和发展中,一方面要注意培养临床哲学思维,如整体与局部、理论-实践-理论、限度的问题、发展与联系等观点;另一方面应在临床实践中通过临床前基本技能培训及临床技能训练逐渐夯实其临床能力.通过开展临床病例讨论、专题讲课、病例总结等可进一步有效地将二者结合以提高口腔正畸医生的临床综合业务素质.     

道德判断中心理状态和事件因果关系的作用:兼对道德判断双加工过程理论的检验

考察青少年儿童和成人在道德判断中利用心理状态和事件因果关系信息的差异,并验证道德判断双加工过程理论.以道德判断中“行为坏的”程度和“应担负的道德责任程度”作为判断问题类型,共有10～11岁和13～15岁的青少年儿童及大学生各120名,完成道德判断测试任务.结果表明在不同的道德判断问题类型下,事件中他人愿望和信念、因果关系信息的作用模式是不同的,支持道德判断双加工过程理论.10～11岁儿童和13～15岁青少年在判断行为坏的程度时,利用心理状态信息和因果关系信息与成人类似.在判断应担负的道德责任程度时,10～11岁儿童更注重行为结果,并且不能综合应用心理状态信息和事件的因果关系信息.13～15岁青少年的道德判断中心理状态信息和事件因果关系信息的作用与成人的情况类似,但在进行应担负的道德责任程度判断时,还不能融合信念与因果关系信息进行道德判断.研究结果为道德判断双加工过程理论提供了支持,而且表明从儿童青少年到成人,利用心理状态和因果关系信息进行道德判断存在不断发展和成熟的过程.     

大学生的冲动性特质与自杀意念的关系:一个有调节的中介模型

以应激-易感模型为依据考察冲动性特质与自杀意念的关系,并在此基础上提出一个有调节的中介模型,探讨负性生活事件影响的中介作用以及家庭环境的调节作用。采用巴瑞特冲动性量表、青少年生活事件量表、家庭环境量表、贝克自杀意念量表对902名大学生进行集体施测,旨在考察负性生活事件的影响对大学生冲动性特质与自杀意念的中介作用以及家庭环境的调节作用,结果表明:(1)冲动性特质和负性生活事件的影响能正向预测大学生的自杀意念;(2)负性生活事件的影响在冲动性特质和自杀意念之间起中介作用;(3)负性生活事件影响的中介作用和冲动性特质的直接作用受家庭环境的调节。这些结果对于综合解释环境与个体因素对自杀意念的作用与机制具有重要意义。     

Quantifier comprehension in corticobasal degeneration

In this study, we investigated patients with focal neurodegenerative diseases to examine a formal linguistic distinction between classes of generalized quantifiers, like "some X" and "less than half of X." Our model of quantifier comprehension proposes that number knowledge is required to understand both first-order and higher-order quantifiers. The present results demonstrate that corticobasal degeneration (CBD) patients, who have number knowledge impairments but little evidence for a deficit understanding other aspects of language, are impaired in their comprehension of quantifiers relative to healthy seniors, Alzheimer's disease (AD) and frontotemporal dementia (FTD) patients [F(3,77)=4.98; p<.005]. Moreover, our model attempts to honor a distinction in complexity between classes of quantifiers such that working memory is required to comprehend higher-order quantifiers. Our results support this distinction by demonstrating that FTD and AD patients, who have working memory limitations, have greater difficulty understanding higher-order quantifiers relative to first-order quantifiers [F(1,77)=124.29; p<.001]. An important implication of these findings is that the meaning of generalized quantifiers appears to involve two dissociable components, number knowledge and working memory, which are supported by distinct brain regions.     

结果预期对青少年攻击性行为的影响：中介效应与调节效应

采用攻击性问卷、关系攻击行为量表、结果预期量表、移情量表和自我控制能力问卷对720名中学生进行调查,考察了结果预期与青少年攻击性行为的关系,以及自我控制在其中的中介作用和移情在其中的调节作用。结果发现:(1)结果预期与青少年的攻击性行为(外部攻击和关系攻击)存在显著负相关;(2)自我控制在结果预期与青少年攻击性行为之间起着完全中介作用;(3)在结果预期对青少年外部攻击行为的预测中,移情发挥了调节作用。在高移情个体中,结果预期并不预测外部攻击行为,而在低移情个体中,结果预期显著地反向预测外部攻击行为;(4)自我控制在结果预期与青少年外部攻击行为之间的中介作用受到移情的调节,高水平的移情能力可以有效地缓解青少年因低自我控制而导致的高攻击性。