Studies of anticipation in bipolar affective disorder

Anticipation refers to the increase in disease severity or decrease in age of onset in successive generations. The concept evolved from the theories and dogma of degeneration that were pervasive in psychiatry and medicine in the late 19th century and into the early 20th century. The term was set aside with the criticism of geneticist Lionel Penrose, who argued that anticipation was the result of ascertainment biases. The renewed interest in anticipation followed the identification of its molecular genetic basis in the form of unstable trinucleotide repeats. Subsequently, several diseases have been studied clinically for the presence of anticipation. Although anticipation has been identified in many diseases, including bipolar disorder, only diseases showing a pattern of progressive neurodegeneration have been associated with unstable trinucleotide repeats. This review summarizes the research on anticipation in bipolar disorder and other secular trends in the patterns of the illness such as the cohort effect. The changing nature of bipolar disorder is likely to be a result of combined influences from several genes, some of which are likely to be in a state of flux, as well as environmental or cultural forces that converge to give the clinical picture of anticipation.     

REMEDIATION OF NEGATIVE SIDE EFFECTS OF AN ON-GOING RESPONSE-COST SYSTEM WITH CHRONIC MENTAL PATIENTS1

Response-cost procedures within a token economy with extremely regressed residents excluded many residents from access to positive reinforcement. Procedures allowing residents to “purchase eligibility” to obtain backup reinforcers through contingent payment on standing fines, combined with proportional fine payoff schedules contingent upon time without new fines, increased payment on fines, reduced incidence of new fines, and increased utilization of backup reinforcers. These modifications removed adverse side effects while retaining the benefits associated with response costs. Failures or adverse effects of elements of token systems should not occasion abandonment of token economies, but rather encourage their continual evaluation and modification.     

The effect of a teacher's presence on the classroom behavior of conduct-problem children

Six institutionalized conduct-problem children performed in a classroom under three reinforcement conditions: (1) noncontingent reinforcement: (2) reinforcement for being on task and (3) reinforcement for the accuracy and rate fo their academic behavior. Within each of these conditions, the teacher was either present throughout the class session or absent for a portion of the session. In the teacher's absence, on-task behavior was markedly reduced and disruption was markedly increased, regardless of the reinforcement condition in operation. In contrast, the teacher's absence had no effect on academic accuracy and had a major effect on academic rate only when reinforcement was delivered noncontingently. Furthermore, the extent to which the children became disruptive in the teacher's absence was reduced when reinforcement was contingent upon academic accuracy and rate, instead of being contingent upon being on task or delivered noncontingently. It is suggested that the reinforcement of academic behavior, rather than on-task behavior or classroom social behavior, not only will improve the latter behaviors as well, but possibly also make them less dependent upon the presence and continued surveillance of the teacher.     

Living with the unexplained: coping,distress, and depression among women with chronic fatigue syndrome and/or fibromyalgia compared to an autoimmune disorder

Chronic fatigue syndrome (CFS) and fibromyalgia are disabling conditions without objective diagnostic tests, clear-cut treatments, or established etiologies. Those with the disorders are viewed suspiciously, and claims of malingering are common, thus promoting further distress. It was hypothesized in the current study that levels of unsupportive social interactions and the coping styles used among those with CFS/fibromyalgia would be associated with perceived distress and depressive symptoms. Women with CFS/fibromyalgia (n = 39), in fact, reported higher depression scores, greater perceived distress and more frequent unsupportive relationships than healthy women (n = 55), whereas those with a chronic, but medically accepted illness comprising an autoimmune disorder (lupus erythematosus, multiple sclerosis, rheumatoid arthritis; n = 28), displayed intermediate scores. High problem-focused coping was associated with low levels of depression and perceived distress in those with an autoimmune condition. In contrast, although CFS/fibromyalgia was also accompanied by higher depression scores and higher perceived distress, this occurred irrespective of problem-focused coping. It is suggested that because the veracity of ambiguous illnesses is often questioned, this might represent a potent stressor in women with such illnesses, and even coping methods typically thought to be useful in other conditions, are not associated with diminished distress among those with CFS/fibromyalgia.     

Do clever old people have earlier and richer first memories?

In a study of 377 people, from 54 to 83 years old, it was shown that the age of earliest memories was unrelated to current age but was related to intelligence. People with high IQ test scores remembered first and second memories at an earlier age than did those with lower IQ test scores. Intervals between first and second memories were briefer for those with high scores. The content of early memories was unrelated to age or intelligence.     

Relations between plasma oxytocin,depressive symptoms and coping strategies in response to a stressor: the impact of social support

Background: Social support can serve as a protective factor against the negative impacts of stressors and may thereby promote well-being. As well, exogenous administration of oxytocin has been tied to diminished stress responses and might also enhance the effects of social support.

Methods/Results: In the current study, conducted among female undergraduate students (N?=?67), higher depressive symptoms were related to lower endorsements of problem-focused coping in response to a psychosocial stressor comprising the Trier Social Stress test (TSST). However, the relation between depressive symptoms and problem-focused coping was absent among participants who had a close female friend present serving as social support prior to the stressor experience. Additionally, endogenous plasma oxytocin levels were related to certain coping strategies being favored (e.g., problem-solving, humor, cognitive distraction, self-blame and support seeking) in response to the psychosocial stressor. However, the strength of these relations varied as a function of whether individuals had social support present or not.

Conclusion: These findings confirm the positive impact of social support in attenuating the relation between depressive symptoms and specific coping methods. The results of this study are consistent with view that oxytocin levels are accompanied by particular stress responses, possibly through the promotion of coping methods endorsed.     

Affective,normative, and continuance commitment levels across cultures: A meta-analysis

With increasing globalization of business and diversity within the workplace, there has been growing interest in cultural differences in employee commitment. We used meta-analysis to compute mean levels of affective (AC; K = 966, N = 433,129), continuance (CC; K = 428, N = 199,831), and normative (NC; K = 336, N = 133,277) organizational commitment for as many as 54 countries and nine geographic regions, and used cultural values/practices from the Hofstede (2001), Schwartz (2006), and GLOBE (House, Hanges, Javidan, Dorfman, & Gupta, 2004) taxonomies to account for observed variance. We found that cultural values/practices explained the greatest amount of variance in NC, followed by AC; they did not explain variance in CC. When economic indicators were controlled, Schwartz's value orientations accounted for the most incremental variance, particularly in NC. We provide country-level normative data for the three components of commitment and discuss the implications of our findings for multi-national organizations as well as for companies employing individuals with varying cultural backgrounds.