Inhibition of the LH Surge by Restraint Stress in Cyclic Rats: Studies on the Role of GABAA and GABAB Receptors

There is evidence that stress can alter the activity in the brain of gamma-aminobutyricacid (GABA), a neurotransmitter that has been implicated in the regulation of LH secretion. In the present study the role of GABA in the restraint stress-induced inhibition of the LH surge was investigated in the intact cyclic rat. Intracerebroventricular (icv) administration of the GABAA receptor agonist muscimol (0.1, 0.5 or 1 μg) 5 min before the presumed onset of the pro-oestrous LH surge (at 0900 h) caused a dose dependent suppression of the surge. A single dose of the GABAB receptor agonist baclofen (1 μg; icv) injected at 0855 h postponed the onset of the LH surge, and repeated injections at 0855 and 1130 h suppressed the surge. These data indicate that GABA-ergic activity in the brain can inhibit the LH surge in the cyclic rat via GABAA and GABAB receptors. Pro-oestrous rats were subjected to 5 hrs of restraint starting at 0855 h. Pretreatment with the GABAA receptor antagonist bicuculine (1 μg; icv) at 0840, 0940 and 1040 h or pretreatment with the GABAB receptor antagonist phaclofen (10 μg; icv) at 0840 h were ineffective in preventing the restraint-induced inhibition of the LH surge. The results suggest that GABAA and GABAB receptors are not involved in the inhibitory effect of restraint stress on the LH surge.     

Effect of lingual vibrotactile stimulation on the averaged cortical evoked response

This study was designed to determine the feasibility of using lingual vibrotactile stimulation to elicit an averaged evoked response and to investigate the effects of two supra-threshold intensity levels of lingual vibrotactile stimulation on the electro-cortical activity of the brain. The evoked responses were analyzed according to the amplitude of N1-P2 (in microvolts). Analysis indicates that the tongue can successfully be used as a stimulus site in the elicitation of an evoked response. The amplitudes of the evoked response elicited by 2 micrometers sensation level and 5 micrometers sensation level on the tongue are essentially the same. The relative difference between these levels is not sufficient to produce significant differences in the amplitudes of their respective evoked responses.     

Comparison of the methods of limits and electrodermal response for determination of lingual vibrotactile thresholds.

Lingual vibrotactile thresholds were obtained from 30 adult Ss by the method of limits and operant conditioning of the electrodermal response. Sensitivity of the tongue was measured at 250 Hz. Comparisons of lingual threshold data showed that thresholds obtained by the method of limits were significantly lower than those obtained by the electrodermal response technique. There was a moderate positive correlation between methods however, indicating a substantial relationship. It was concluded that consistent lingual vibrotactile indexes of sensitivity can be obtained using an electrodermal response approach.     

Electrical Injury and Lightning Injury: A Review of Their Mechanisms and Neuropsychological,Psychiatric, and Neurological Sequelae

Exposure to electrical current via industrial or residential accidents or lightning strikes is a serious and growing concern in today's medical community. The sequelae that result are referred to as electrical injury (EI) or lightning injury (LI). The relevant principles in electricity are reviewed with particular attention given to their damaging capabilities on the body. Specific neuropsychological, psychiatric, and neurological signs and symptoms as well as objective measures of psychological and neuropsychological functioning and brain imaging in victims of EI and LI, are reviewed from past research. Important issues relevant to researchers in the field are discussed. Finally, the role that neuropsychology might play in this area is outlined.     

Changes in health-promoting behavior following diagnosis with HIV: prevalence and correlates in a national probability sample.

Diet, exercise, smoking, and substance use patterns affect the course of illness and quality of life for people with HIV. In interviews with a national probability sample of 2,864 persons receiving HIV care, it was found that most had made health-promoting changes in one or more of these behaviors since diagnosis. Many reported increased physical activity (43%) and improved diet (59%). Forty-nine percent of cigarette smokers quit or cut down; 80% of substance users did so. Desire for involvement in one's HIV care and information seeking-positive coping were the most consistent correlates of change. Other correlates varied by health practice but included health status, emotional well-being, demographics, and attitudes toward other aspects of HIV care. Most people with HIV improve their health behavior following diagnosis, but more might be helped to do so by targeting these behaviors in future interventions.     

A methodological review of “method skeptic” reports

The literature purporting to demonstrate that clinical neuropsychology is of limited validity in the forensic setting is reviewed critically and alternative interpretations are discussed. The methodological, procedural, conceptual, data analytical and survey/research design limitations are evaluated.Portions of this paper were presented at the 1992 annual meeting of the National Academy of Neuropsychology, Pittsburgh, Pennsylvania.     

Socialization and career orientation among black and white college women

In a study of career orientation among black and white college women, support was found for hypotheses derived from postulates of Rotter's Social Learning Theory. Compared to whites, (1) blacks were less likely to expect the level of work involvement preferred; (2) blacks expected more employment; and (3) blacks were more likely to prefer less employment than they realistically expected. Antecedents of career expectation were categorized as internal, external, or neutral. As hypothesized, variables expressive of external control predicted level of career expectation among blacks, whereas variables expressive of internal control predicted high career expectations among whites.     

A Visual Representation to Quantitate,Diagnose, and Improve Creativity in Insight Problem Solving

A new visual representation for insight problems permits 22 new quantitative measures; which leads to a detailed diagnosis of a person's (or team's) creative weaknesses; which then leads to prescribing targeted, effective counter‐techniques for each weakness. Currently, only two measures are consistently used for insight problem solving: the number of problems solved and the time to solve the problems. These coarse measurements do not reveal the intricate dynamics of solving insight problems. Furthermore, four commonly used creativity measures (i.e., fluency, originality, flexibility, and elaboration) are often not applied to insight problems. This new visualization permits the easy application of all four creativity measures. I challenge creativity researchers to help determine which of the 22 proposed quantitative measures are the most diagnostic for insight problem solving in isolation and, in a weighted linear combination, which might yield an effective quotient (i.e., overall measure) of insight problem solving ability.     

The allure of the alignable: younger and older adults' false memories of choice features

When making choices, people often try to directly compare the features of different options rather than evaluating each option separately. Not every feature has an analogous (or alignable) feature in the other option, however. In this study, both younger and older adults filled in such gaps when remembering, creating features in the other option to contrast with existing features. Thus, participants had a tendency to remember choice options as more comparable than they originally were. High performance on tasks tapping strategic processing was associated with a pattern of mostly feature-based comparisons during choice for older adults but with a pattern of mostly option-based comparisons for younger adults. This pattern suggests that younger and older adults' comparison processes are influenced by different goals.     

A Review of Symptoms Commonly Associated with Menopause: Implications for Clinical Neuropsychologists and Other Health Care Providers

Menopause is a process, either naturally or medically induced, that occurs in nearly all women at some point in life. Some of the most commonly reported symptoms associated with menopause are hot flushes/flashes, fatigue, headaches, irritability, insomnia, and depression. These symptoms overlap with symptoms commonly reported in Traumatic Brain Injury (TBI) as well as postconcussive syndrome. This overlap between symptoms commonly associated with menopause and neuropsychological conditions makes it necessary to have the base rates of these symptoms and conditions available. The purpose of the present review was to consolidate the clinical literature on the most commonly reported menopausal symptoms and to calculate the base rates associated with these symptoms.