Expression of the immediate-early gene-encoded protein Egr-1 (zif268) during in vitro classical conditioning

Expression of the immediate-early genes (IEGs) has been shown to be induced by activity-dependent synaptic plasticity or behavioral training and is thought to play an important role in long-term memory. In the present study, we examined the induction and expression of the IEG-encoded protein Egr-1 during an in vitro neural correlate of eyeblink classical conditioning. The results showed that Egr-1 protein expression as determined by immunocytochemistry and Western blot analysis rapidly increased during the early stages of conditioning and remained elevated during the later stages. Further, expression of Egr-1 protein required NMDA receptor activation as it was blocked by bath application of AP-5. These findings suggest that the IEG-encoded proteins such as Egr-1 are activated during relatively simple forms of learning in vertebrates. In this case, Egr-1 may have a functional role in the acquisition phase of conditioning as well as in maintaining expression of conditioned responses.     

Young children's understanding of multiple object identity: appearance, pretense and function

Evidence from theory-of-mind tasks suggests that young children have substantial difficulty thinking about multiple object identity and multiple versions of reality. On the other hand, evidence from children's understanding of pretense indicates that children have little trouble understanding dual object identity and counterfactual scenarios that are involved in pretend play. Two studies reported here show that this competence is not limited to pretend play. Three-year-olds also understand the dual identity involved in unusual functional use (X is being used as Y), even though they have difficulty understanding deceptive appearance (X looks like Y). We suggest that children are able to distinguish extrinsic object properties from intrinsic ones (function vs. category-membership) better than they can distinguish superficial object properties from deep ones (appearance vs. category-membership).     

Aristotle in Prussian Gymnasiums: Why the Texts of the Ancient Philosopher Became Popular for Teaching Logic

During the nineteenth century, German philosophy developed from a type of general knowledge to an academic discipline at the university. Changes across disciplines to the philosophy of science and psychological surveys created new challenges for the place and purpose of philosophy in the educational system. The content of logic courses for secondary schools (Gymnasiums) was centred on the dissociation of nature and the scale of logic.In this paper, I will examine a number of projects for teaching philosophy at the secondary school level from new humanism to reduce philosophical to philological concerns about different projects offered by Niethammer, Hegel and Herbart. Then, I will focus on the most successful – Adolf Trendelenburg’s Elements of Aristotle’s Logic (1st edition of 1836). This work is a compilation of the logical texts of Aristotle, and for as long as sixty years, it was an official textbook in Prussian secondary schools. The aim of the paper is to show how the rethinking of Aristotle’s heritage affected the theoretical and ideological expectations of propaedeutic courses and transformed the image of logic as a philosophical discipline.     

The feasibility,acceptability and possible benefit of a positive psychology intervention group in an adolescent inpatient eating disorder service

Positive affect focused therapies could increase subjective happiness and life satisfaction for patients with eating disorders (EDs), illnesses known to significantly impact quality of life. This longitudinal pilot study aimed to develop and implement a five session ‘Positivity Group’ using positive psychology interventions (PPIs) in an adolescent ED inpatient service. Eight female inpatients aged 11–18 years attended the group and subjective happiness and life satisfaction were assessed before, after and at 6-month follow-up. Patients provided feedback on acceptability and feasibility was assessed via patient engagement, facilitator and team feedback and the data support the feasibility and acceptability of the group. A possible benefit was derived from the group, with 75% of patients reporting meaningful improvement in subjective happiness and 87.5% in life satisfaction. Involving the wider team and supporting homework were identified as considerations for future replication alongside the assessment of implementation, acceptability, feasibility and effectiveness in other clinical contexts.     

Word learning in dogs?

In a recent paper, Kaminski, Call and Fischer report pioneering research on word-learning in a dog. In this commentary we suggest ways of distinguishing referential word use from mere association. We question whether the dog is reasoning by exclusion and, if so, compare three explanations - learned heuristics, default assumptions, and pragmatic reasoning - as they apply to children and might apply to dogs. Kaminski et al.'s work clearly raises important questions about the origins and basis of word learning and social cognition.     

Nanostructure and related mechanical properties of an Al–Mg–Si alloy processed by severe plastic deformation

Microstructural features and mechanical properties of an Al–Mg–Si alloy processed by high-pressure torsion (HPT) have been investigated using transmission electron microscopy, X-ray diffraction, three-dimensional atom probe, tensile tests and micro-hardness measurements. It is shown that HPT processing of the Al–Mg–Si alloy leads to a much stronger grain size refinement than of pure aluminium (down to 100 nm). Moreover, massive segregation of alloying elements along grain boundaries is observed. This nanostructure exhibits a yield stress even two times higher than that after a standard T6 heat treatment of the coarse-grained alloy.     

Need for closure is associated with urgency in perceptual decision-making

Constant decision-making underpins much of daily life, from simple perceptual decisions about navigation through to more complex decisions about important life events. At many scales, a fundamental task of the decision-maker is to balance competing needs for caution and urgency: fast decisions can be more efficient, but also more often wrong. We show how a single mathematical framework for decision-making explains the urgency/caution balance across decision-making at two very different scales. This explanation has been applied at the level of neuronal circuits (on a time scale of hundreds of milliseconds) through to the level of stable personality traits (time scale of years).     

Perceptual grouping operates independently of attentional selection: Evidence from hemispatial neglect

To what extent can human observers process visual information that is not currently the focus of attention? We evaluated the extent to which unattended visual information (i.e., that which appears on the neglected side of space in individuals with hemispatial neglect) is perceptually organized and influences the perceptual processing of information on the attended side. To examine this, patients (and matched controls) judged whether successive, complex checkerboard stimuli (targets), presented entirely to their intact side of space, were the same or different. Concurrent with this demanding task, irrelevant distractor elements appeared on the unattended side and either changed or retained their perceptual grouping on successive displays, independently of changes in the ipsilesional task-relevant target. Changes in the grouping of the unattended task-irrelevant distractor elements produced congruency effects on the attended target-change judgment to the same extent in the neglect patients as in the control participants, and this was true even in those patients with severe attentional deficits. These results suggest that some perceptual processes, such as grouping, can operate in the absence of attention.     

The Novelty of Nano and the Regulatory Challenge of Newness

A great deal has been made of the question of whether nano-materials provide a unique set of ethical challenges. Equally important is the question of whether they provide a unique set of regulatory challenges. In the last 18 months, the US Environmental Protection Agency has begun the process of trying to meet the regulatory challenge of nano using the Toxic Substances Control Act (1976)(TSCA). In this central piece of legislation, ‘newness’ is a critical concept. Current EPA policy, we argue, does not adequately (or ethically) deal with the novelty of nano. This paper is an exploration of how to do a better job of accounting for nanomaterials as ‘new.’ We explore three alternative ways that nanomaterials might be made to fall under the TSCA regulatory umbrella. Since nanomaterials are of interest precisely because of the exciting new properties that emerge at the nano-scale, each of these three alternatives must meet what we call the ‘novelty condition’ and avoid what we call the ‘central paradox’ of existing regulatory policy. Failure to meet either of these conditions is a moral failure. We examine both the strengths and weaknesses of each alternative in order to illuminate the conceptual, practical, and moral challenges of novelty.