REM sleep deprivation increases early morning pineal melatonin in castrated rats

Recently nighttime melatonin levels have been shown to be attenuated in depressive patients or patients with dementia of the Alzheimer type. On the other hand, depression can be transiently relieved by deprivation of rapid eye movement sleep. Since exogenous melatonin administration increases rapid eye movement sleep and slow wave sleep in the rat, could rapid eye movement sleep deprivation then inversely influence endogenous melatonin production? We found indices that in castrated Wistar rats 4 days of rapid eye movement sleep deprivation by the cuff pedestal method elevates the pineal content of melatonin by a factor of two at 1 to 2 h after light onset. Rapid eye movement sleep is thus suggested to influence pineal activity. This mechanism might be involved in the human depression-alleviating effect of rapid eye movement sleep deprivation.     

The development and predictive relations of play and language across the second year.

The play and language development of 171 toddlers was examined at 14 and 18 months by observing their activities on the Symbolic Play Test and by assessing their language skills using the MacArthur Communicative Development Inventories (MCDI) and the Reynell Developmental Language Scales. Additionally, data from the Bayley Scales of Infant Development and the MCDI were obtained at 24 months, in order to investigate how play and language measures taken at 14 and 18 months predict children's development at the age of 2 years. The results showed that the vocabulary production and symbolic play of the 14-month-old toddlers made a unique contribution to their language and cognitive skills at the age of 2 years, while at 18 months only language variables made a similar contribution. Other-directed pretense discriminated between the children's subsequent language and cognitive skills best, whereas nonsymbolic play had no independent predictive contribution. Significant gender differences were found in the use of nonsymbolic and symbolic play acts already at 14 months. Gender did not, however, contribute to the prediction of the children's subsequent skills, whereas maternal education significantly added to the prediction of the 2-year-olds' maximum sentence length and that of their cognitive development.     

Relieved after GP's consultation? Change in the complaint-related worry of young adult patients

Patients tend to get relieved during a general practitioner's (GP's) consultation, but some patients remain worried. This study aimed to explore the change in worry and to identify factors associated with non-worry, relief and persistent worry by interviewing GPs' patients before and after a consultation. Patients aged 18-39 years consulting their doctor because of a somatic complaint were interviewed about their complaint-related worry, complaint characteristics and their expectations and experiences concerning the consultation. They completed questionnaires about general illness worry (IWS) and psychiatric symptoms (SCL-90). The GPs assessed the medical severity of each complaint and reported whether the complaint was medically explained. Persistently worried patients reported more anxiety and thoughts that something was seriously wrong in their body. They expected more often medical examinations, were less certain about what was wrong with them and considered their complaint more severe than the other patients, even though its medical severity did not differ from that of the other patients.     

Communication Deviances and Clarity Among the Mothers of Normally Achieving and Learning-Disabled Boys.

The main purpose of the study was to reexamine the association between maternal communication deviances and learning disabilities in children. In this study, we adapted and extended the procedure used b Ditton, Green, and Singer (1987). A two-part experimental task was used: one in which the child could not request any clarification of mother's insruction, and another in which the mother and child could communicate. Both communication deviances and the clarity of mother's communication were analyzed. The subjects were 60 mother-child paires in which half of the children had learning disabilities and the other haalf were normally achieving children matched for age and parents' SES. The dyads were vedetaped in a laboratory setting. The mothers o f learning-disabled (LD) children were found to give less exact instructions and to present more ambiguous messages to the child than the mothers of non-LD children.     

Design in the Local Economy: Location Factors and Externalities of Design

This article deals with the relation between design and local economy. The study explains the mechanisms, which lead innovative and knowledge intensive activities to concentrate in metropolises and major cities. In addition, there is a tendency that within cities, these activities concentrate to certain locations. Intensive and easy communication with deep social dimension connected to it creates positive externalities and spillover effects of knowledge. This is fruitful not only for the design business itself but also to a large extent to other innovative activities. The location of design industry is illustrated by empirical data in the Helsinki Metropolitan Area, Finland. Design has a great significance for brand and value creation processes of many important, global businesses, like mobile phone industry or machinery, in addition to design industries itself. Via this, link design firms together with research and education institutions are an important part of the global industrial clusters.     

Effects of rapid eye movement sleep deprivation on regional brain metabolism as measured by 2-[14C]deoxyglucose autoradiography

Regional brain metabolic activity of six male Sprague-Dawley rats was investigated with 2-[14C]deoxyglucose autoradiography. Regional brain metabolic activity was determined bilaterally for 60 brain structures, using laser densitometry. After 5 days of uninterrupted rapid eye movement sleep deprivation, increased metabolic activity was found in the lateral habenula, the caudal and middle parts of the limbic system, and in the corpus callosum.     

The Gendering of Language: A Comparison of Gender Equality in Countries with Gendered, Natural Gender, and Genderless Languages

Feminists have long argued that sexist language can have real world consequences for gender relations and the relative status of men and women, and recent research suggests that grammatical gender can shape how people interpret the world around them along gender lines (Boroditsky 2009). Although others have theorized about the connection between grammatical gender in language and societal gender equality (Stahlberg et al. 2007), the current work tests this link empirically by examining differences in gender equality between countries with gendered, natural gender, and genderless language systems. Of the 111 countries investigated, our findings suggest that countries where gendered languages are spoken evidence less gender equality compared to countries with other grammatical gender systems. Furthermore, countries where natural gender languages are spoken demonstrate greater gender equality, which may be due to the ease of creating gender symmetric revisions to instances of sexist language.     

Verbs and Syntactic Frames in Children’s Elicited Actions: A Comparison of Tamil- and English-Speaking Children

We directly compare children learning argument expressing and argument dropping languages on the use of verb meaning and syntactic cues, by examining enactments of transitive and intransitive verbs given in transitive and intransitive syntactic frames. Our results show similarities in the children’s knowledge: (1) Children were somewhat less likely to perform an action when the core meaning of a verb was in conflict with the frame in which it was presented; (2) Children enacted the core meaning of the verb with considerable accuracy in all conditions; and (3) Children altered their actions to include or not include explicit objects appropriately to the frame. The results suggest that 3-year-olds learning languages that present them with very different structural cues still show similar knowledge about and sensitivity to the core meanings of transitive and intransitive verbs as well as the implications of the frames in which they appear.     

Predicting delayed letter knowledge development and its relation to grade 1 reading achievement among children with and without familial risk for dyslexia

The authors examined the developmental trajectories of children's early letter knowledge in relation to measures spanning and encompassing their prior language-related and cognitive measures and environmental factors and their subsequent Grade 1 reading achievement. Letter knowledge was assessed longitudinally at ages 4.5, 5.0, 5.5, and 6.5 years; earlier language skills and environmental factors were assessed at ages 3.5 and 4.5 years; and reading achievement was assessed at the beginning and end of Grade 1. The analyses were conducted on a longitudinal data set involving children with and without familial risk for dyslexia. Emerging from the trajectory analysis of letter knowledge were 3 separate clusters: delayed (n = 63), linearly growing (n = 73), and precocious (n = 51). The members of the delayed cluster were predominantly children with familial risk for dyslexia, and the members of the precocious cluster were predominantly control group children. Phonological sensitivity, phonological memory, and rapid naming skills predicted delayed letter knowledge. Environmental predictors included level of maternal education and the amount of letter name teaching. Familial risk for dyslexia made a significant contribution to the predictive relations. Membership in the delayed cluster predicted poor reading performance at Grade 1.     

Social interactional behaviors and symbolic play competence as predictors of language development and their associations with maternal attention-directing strategies

Children’s early social interactional behaviors and symbolic play competence were studied at 14 months in a sample of 111 mother-infant pairs. The categories of social interactional behaviors, joint visual attention, socially coordinated and object oriented interactions were assessed via observations of mother-infant joint play. An index of symbolic play was derived from the child’s solitary play, which was assessed independently. We examined both the interrelations of these two types of early language predictors, and their relation to children’s language skills and maternal attention-directing strategies. Measures of children’s language comprehension and production were obtained using the MacArthur Communicative Development Inventories at 14 months, and Reynell Developmental Language Scales at 18 and 30 months. We found that at 14 months, social interactional behaviors and symbolic play competence were not statistically significantly related to each other. In line with our hypotheses, social interactional skills were associated more strongly with language production, and symbolic play competence more strongly with language comprehension. Maternal attention-directing strategies were strongly related to both children’s social interactional behaviors and symbolic play competence. Our findings indicated that maternal strategies that expanded the infant’s level of functioning were more effective in stimulating the children’s language development than were the other types of strategies.