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Andero R Torras-Garcia M Quiroz-Padilla MF Costa-Miserachs D Coll-Andreu M 《Neurobiology of learning and memory》2007,87(4):510-521
The pedunculopontine tegmental nucleus (PPTg) is involved in the regulation of thalamocortical transmission and of several functions related to ventral and dorsal striatal circuits. Stimulation of the PPTg in anesthetized animals increases cortical arousal, cortical acetylcholine release, bursting activity of mesopontine dopaminergic cells, and striatal dopamine release. It was hypothetized that PPTg stimulation could improve learning by enhancing cortical arousal and optimizing the activity of striatal circuits. We tested whether electrical stimulation (ES) of the PPTg, applied to freely-moving awake rats previously implanted with a chronic electrode, would improve the acquisition and/or the retention of two-way active avoidance conditioning, and whether this effect would depend on the specific PPTg region stimulated (anterior vs posterior) and on the time of ES: just before (pre-training) or after (post-training) each of three training sessions. The treatment consisted of 20 min of ES (0.2 ms pulses at 100 Hz; current intensity: 40-80 microA). The results showed that (1) this stimulation did not induce either any signs of distress nor abnormal behaviors, apart from some motor stereotyped behaviors that disappeared when current intensity was lowered; (2) pre-training ES applied to the anterior PPTg improved the acquisition of two-way active avoidance, (3) no learning improvement was found after either post-training ES of the anterior PPTg, or pre- and post-training ES of the posterior PPTg. The results give support to a role of PPTg in learning-related processes, and point to the existence of functional PPTg regions. 相似文献
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van Overveld Thijs Sol Daniel Blanco Guillermo Margalida Antoni de la Riva Manuel Donzar Jos Antonio 《Animal cognition》2022,25(3):495-507
Animal Cognition - Despite important recent advances in cognitive ecology, our current understanding of avian cognition still largely rests on research conducted on a few model taxa. Vultures are... 相似文献
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Maria Jesús Blasco Gemma Vilagut Jos Almenara Miquel Roca Jos Antonio Piqueras Andrea Gabilondo Carolina Lagares Victoria Soto‐Sanz Itxaso Alayo Carlos G. Forero Enrique Echeburúa Margalida Gili Ana Isabel Cebri Ronny Bruffaerts Randy P. Auerbach Matthew K. Nock Ronald C. Kessler Jordi Alonso 《Suicide & life-threatening behavior》2019,49(3):881-898
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