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MM Roozendaal De Kruijf HF RJ Reuling A Threels JJ Swarts VM Wiegant JA Mattheij 《Stress (Amsterdam, Netherlands)》1997,1(4):241-248
There is evidence that stress can alter the activity in the brain of gamma-aminobutyricacid (GABA), a neurotransmitter that has been implicated in the regulation of LH secretion. In the present study the role of GABA in the restraint stress-induced inhibition of the LH surge was investigated in the intact cyclic rat. Intracerebroventricular (icv) administration of the GABAA receptor agonist muscimol (0.1, 0.5 or 1 μg) 5 min before the presumed onset of the pro-oestrous LH surge (at 0900 h) caused a dose dependent suppression of the surge. A single dose of the GABAB receptor agonist baclofen (1 μg; icv) injected at 0855 h postponed the onset of the LH surge, and repeated injections at 0855 and 1130 h suppressed the surge. These data indicate that GABA-ergic activity in the brain can inhibit the LH surge in the cyclic rat via GABAA and GABAB receptors. Pro-oestrous rats were subjected to 5 hrs of restraint starting at 0855 h. Pretreatment with the GABAA receptor antagonist bicuculine (1 μg; icv) at 0840, 0940 and 1040 h or pretreatment with the GABAB receptor antagonist phaclofen (10 μg; icv) at 0840 h were ineffective in preventing the restraint-induced inhibition of the LH surge. The results suggest that GABAA and GABAB receptors are not involved in the inhibitory effect of restraint stress on the LH surge. 相似文献
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Symonds LL Yang L Mande MM Mande LA Blow AJ Osuch JR Boivin MB Giordani B Haan PS Smith SS 《Journal of religion and health》2011,50(2):437-446
This study was designed to develop and validate a method for enhancing spiritual feelings, particularly in women who have
received a diagnosis of breast cancer. The protocol specifically was developed to be used in functional magnetic resonance
imaging (fMRI) studies. Eighteen breast cancer survivors rated pictures for their ability to enhance feelings of spirituality,
happiness, and sadness. Results indicate that presenting carefully selected pictures with spiritual content (e.g., nature
scenes, people engaged in contemplative behaviors) can effectively enhance spiritual feelings among breast cancer survivors.
Future fMRI studies will explore the use of the protocol developed in this study for investigating neural activity during
spiritual feelings and states. 相似文献
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