Normality in medicine: an empirical elucidation

Introduction

Dementia diseases, especially Alzheimer’s disease (AD), are of considerable importance in terms of social policy and health economics. Moreover, against the background of the current Karlsruhe judgement on the legalisation of assisted suicide, there are also questions to be asked about medical humanities in AD.

Methodology

Relevant literature on complementary forms of therapy and prognosis was included and discussed.

Results

Creative sociotherapeutic approaches (art, music, dance) and validating psychotherapeutic approaches show promise for suitability and efficiency in the treatment of dementia, but in some cases still need to be scientifically tested. Biomarker-based early diagnosis of dementia diseases is increasingly becoming a subject of debate against the background of the Karlsruhe ruling.

Discussion

Needs-oriented and resource-enhancing approaches can make a significant contribution to improving the quality of life of people with dementia. The discussion on the issue of “assisted suicide” should include questions of the dignity and value of a life with dementia.

Outlook

The integrative dementia therapy model can be complemented by a religion- and spirituality-based approach. Appropriate forms of psychotherapy should be scientifically evaluated.

     

Neuropsychology of Environmental Navigation in Humans: Review and Meta-Analysis of fMRI Studies in Healthy Participants

In the past 20 years, many studies in the cognitive neurosciences have analyzed human ability to navigate in recently learned and familiar environments by investigating the cognitive processes involved in successful navigation. In this study, we reviewed the main experimental paradigms and made a cognitive-oriented meta-analysis of fMRI studies of human navigation to underline the importance of the experimental designs and cognitive tasks used to assess navigational skills. We performed a general activation likelihood estimation (ALE) meta-analysis of 66 fMRI experiments to identify the neural substrates underpinning general aspects of human navigation. Four individual ALE analyses were performed to identify the neural substrates of different experimental paradigms (i.e., familiar vs. recently learned environments) and different navigational strategies (allocentric vs. egocentric). Results of the general ALE analysis highlighted a wide network of areas with clusters in the occipital, parietal, frontal and temporal lobes, especially in the parahippocampal cortex. Familiar environments seem to be processed by an extended temporal-frontal network, whereas recently learned environments require activation in the parahippocampal cortex and the parietal and occipital lobes. Allocentric strategy is subtended by the same areas as egocentric strategy, but the latter elicits greater activation in the right precuneus, middle occipital lobe and angular gyrus. Our results suggest that different neural correlates are involved in recalling a well-learned or recently acquired environment and that different networks of areas subtend egocentric and allocentric strategies.     

Flashbulb memories of the Pope's resignation: Explicit and implicit measures across differing religious groups

In the present paper, we aimed to provide evidence in support of the idea tested in a recent study by Lanciano and colleagues that flashbulb memories (FBMs) are a special class of autobiographical memories that can be assessed through the autobiographical implicit association test (aIAT). FBMs and event memories (EMs) for the news of the resignation of Pope Benedict XVI were evaluated in three samples of churchgoer Catholic, non-churchgoer Catholic and Evangelical Italian participants through the traditional self-report measures (specificity/accuracy, confidence, consistency) and aIAT indices. Results confirmed the strength of the association between FBM and true information. The aIAT effect was stronger for FBMs than for EM details, and for Catholic respondents who were the group most concerned by the original event. Furthermore, the use of implicit measures for memory assessment concurs with the traditional self-report indices of FBMs. The present evidence supports the idea that FBMs are special autobiographical memories which remain detailed, certain and consistent over time.     

Long- and short-term plastic modeling of action prediction abilities in volleyball

Athletes show superior abilities not only in executing complex actions, but also in anticipating others' moves. Here, we explored how visual and motor experiences contribute to forge elite action prediction abilities in volleyball players. Both adult athletes and supporters were more accurate than novices in predicting the fate of volleyball floating services by viewing the initial ball trajectory, while only athletes could base their predictions on body kinematics. Importantly, adolescents assigned to physical practice training improved their ability to predict the fate of the actions by reading body kinematics, while those assigned to the observational practice training improved only in understanding the ball trajectory. The results suggest that physical and observational practice might provide complementary and mutually reinforcing contributions to the superior perceptual abilities of elite athletes. Moreover, direct motor experience is required to establish novel perceptuo-motor representations that are used to predict others' actions ahead of realization.     

Between-task transfer of learning from spatial compatibility to a color stroop task

Responses to a relevant stimulus dimension are faster and more accurate when the stimulus and response spatially correspond compared to when they do not, even though stimulus position is irrelevant (Simon effect). It has been demonstrated that practicing with an incompatible spatial stimulus-response (S-R) mapping before performing a Simon task can eliminate this effect. In the present study we assessed whether a learned spatially incompatible S-R mapping can be transferred to a nonspatial conflict task, hence supporting the view that transfer effects are due to acquisition of a general "respond to the opposite stimulus value" rule. To this aim, we ran two experiments in which participants performed a spatial compatibility task with either a compatible or an incompatible mapping and then transferred, after a 5 min delay, to a color Stroop task. In Experiment 1, responses were executed by pressing one of two keys on the keyboard in both practice and transfer tasks. In Experiment 2, responses were manual in the practice task and vocal in the transfer task. The spatially incompatible practice significantly reduced the color Stroop effect only when responses were manual in both tasks. These results suggest that during practice participants develop a response-selection strategy of emitting the alternative spatial response.     

Does aging affect the formation of new topographical memories? Evidence from an extensive spatial training

A decline in navigational abilities is a consistent feature of aging. Although many studies focused on recall of navigational information, the impact of time and type of learning on recall has received little attention. We submitted older adults and young participants to an extensive training of an ecological environment, from both route and survey perspectives. Then, we tested participants’ learning using from both route and survey perspectives. Although older adults benefit from the extensive training, they did not reach the same performance of the young participants. Despite this main effect of age, the effect of the type of learning was the same in the two groups. Congruence between type of learning and recall led to better performance in both groups. We discuss these findings in the light of cognitive models of human navigation and aging. Useful suggestions about how these findings may inform a specific cognitive intervention in older adults are also provided.     

The role of Broca's area in speech perception: evidence from aphasia revisited

Motor theories of speech perception have been re-vitalized as a consequence of the discovery of mirror neurons. Some authors have even promoted a strong version of the motor theory, arguing that the motor speech system is critical for perception. Part of the evidence that is cited in favor of this claim is the observation from the early 1980s that individuals with Broca’s aphasia, and therefore inferred damage to Broca’s area, can have deficits in speech sound discrimination. Here we re-examine this issue in 24 patients with radiologically confirmed lesions to Broca’s area and various degrees of associated non-fluent speech production. Patients performed two same-different discrimination tasks involving pairs of CV syllables, one in which both CVs were presented auditorily, and the other in which one syllable was auditorily presented and the other visually presented as an orthographic form; word comprehension was also assessed using word-to-picture matching tasks in both auditory and visual forms. Discrimination performance on the all-auditory task was four standard deviations above chance, as measured using d′, and was unrelated to the degree of non-fluency in the patients’ speech production. Performance on the auditory–visual task, however, was worse than, and not correlated with, the all-auditory task. The auditory–visual task was related to the degree of speech non-fluency. Word comprehension was at ceiling for the auditory version (97% accuracy) and near ceiling for the orthographic version (90% accuracy). We conclude that the motor speech system is not necessary for speech perception as measured both by discrimination and comprehension paradigms, but may play a role in orthographic decoding or in auditory–visual matching of phonological forms.     

Genetic and Environmental Influences on Achievement Goal Orientations Shift with Age

Students engage in learning activities with different achievement goal orientations. Some students pursue learning for learning sake (i.e. mastery goal orientation), some are driven by gaining favourable judgement of their performance (i.e. performance approach goal orientation), and others focus on avoiding negative judgement (i.e. performance avoidance goal orientation). These goal orientations are linked with academic achievement, and troublingly, students report decreasing levels of goal orientations across the school years. However, little is known concerning the mechanisms that drive this decline. In a large (N = 891 twin pairs) cross‐sectional genetically informative sample (age = 8 to 22 years), we found that older students reported lower goal orientations. Then, we identified shifts in the magnitude of genetic and environmental variance in each goal orientation. For example, variance in mastery goal orientation was primarily associated with environmental factors during the elementary school years. As students entered high school, genetic influences increased, replacing shared environmental influences. Finally, we situated these findings in the larger nomological network by testing associations with psychological constructs (e.g. personality and cognitive ability) and contextual variables (e.g. parents, schools, and peers). The development of academic motivation is complex with many interconnecting factors that appear to shift with age © 2019 European Association of Personality Psychology