Mini-Review; Stress Genes: An Introductory Overview

Molecular sequence data, made available in the last 15 years or so, have led to the classification of living cells into three phylogenetic domains: Bacteria, Archaea, and Eucarya. All the organisms that have been tested belonging to either domain were capable of mounting a stress response with essentially the same characteristics, regardless of the stressor. The protagonists in the cell's stress response are the stress genes and their protein products. Some of the latter are molecular chaperones. Under physiological conditions, these chaperones aid other cellular proteins to fold properly and achieve a native -functional- configuration, and to translocate from the place of synthesis to the cell's locale in which they will operate. In a stressed cell, the stress proteins that are chaperones protect other molecules from denaturation and help those partially damaged to regain a functional configuration. Thus, cell death is avoided and recovery is enhanced. The study of stress genes and proteins has progressed considerably in organisms belonging to the domains Bacteria and Eucarya. Less is known about the archaeal stress genes. Here, research with an organism from the Archaea is discussed, focusing on the stress genes of the hsp70 (dnaK) locus. Future perspectives for basic and applied research within the health sciences and biotechnology industries are presented.     

Motion as a Concept,an Insufficient Element in the Kantian Philosophy

Axiomathes - This article examines the Kantian ideas on motion in his work Metaphysical Foundations of Natural Science. In that essay, Kant holds that motion as a concept—from its connotation...     

Grant Me the Knowledge of What I Want Because All I Know Is That I Want: A Lacanian View of Hysteria

ABSTRACT

Freud’s work with hysterics led him to the discovery of the unconscious and the founding of psychoanalysis. The dream of the beautiful butcher’s wife, one of Freud’s patients, is examined following Lacan’s added insights that give full credit to his well known statement: “The unconscious is structured like a language.” Three basic identifications are presented by Lacanian analysis and I add a clinical vignette that exemplifies my work in the treatment of a couple.     

The pathology of cellular anti-stress mechanisms: a new frontier

Exposure to stressors is an omnipresent variable for all living organisms, which have evolved anti-stress mechanisms to deal with the consequences of stress. The chaperoning systems are among these mechanisms, and their central components are the molecular chaperones that play important roles in protein biogenesis. Recent data suggest that failure of the chaperoning systems due to defective chaperones, for example, leads to pathology. Consequently, medical researchers and practitioners must now also consider the chaperoning systems, both as potentially major players in pathogenesis and as diagnostic-prognostic indicators.     

Externalizing behaviors and attachment disorganization in children of different‐sex separated parents: The protective role of joint physical custody

The aim of this study was to examine the relationship between externalizing behaviors and the quality of attachment representations in preschool children, and to determine if family type and custody arrangement had a moderating effect on this relationship. The participants were 33 girls and 31 boys (n = 64) aged between three and six years (M = 4.75; SD = 0.87 years) and their mothers. Among them, 36 came from “intact” families, 13 were living mainly with their mothers and 15 were in joint physical custody. Children’s attachment representations were assessed with the Attachment Story Completion Task (Bretherton, Ridgeway & Cassidy, 1990). Mothers reported on their child’s behavior problems using the Child Behavior Checklist (Achenbach & Rescorla, 2001) and on their alliance with the father using the Parenting Alliance Inventory (Abidin & Brunner, 1995). Although children’s externalizing behaviors were found to be associated with the disorganization of their attachment representations, this relationship was significantly weaker and was non‐significant for children in joint physical custody. Thus, the results of this pilot study suggest that joint custody may protect children of separated parents from the effects of attachment disorganization on externalizing behaviors.     

Induction from a single instance: formation of a novel category

This study examines whether preschoolers can use information from a known category to induce a characteristic attribute of a novel, contrasting category based on a single instance. We showed 32 four-year-olds three instances of a Given Category and one instance of a Target Category. These objects could vary along two attribute dimensions, such as color and shape. All instances of the Given Category shared identical values of one attribute (e.g., all were blue), but could have different values of the other attribute (e.g., a circle, a square, and a triangle). The single instance of the Target Category was different from the Given on both attribute dimensions (e.g., a red diamond). Children gave yes/no judgements as to whether additional objects were instances of the Target Category. There were two possible sources of information about the relevance of an attribute to classification: explicit (labeling) and implicit (variation in the Given Category). There were four conditions such that each source of information was either available or not. Both types of information were effective in eliciting inductions of the relevant kind of attribute and the characteristic value of this attribute in the novel category (explicit: p = .0004; implicit: p = .031). This suggests that children use an inductive bias that the instances of two related but distinct categories tend to be alike in the same way.