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M. B. Sterman J. J. Lynch M. T. Orne D. Paskewitz J. Costello N. Nicolov O. Diankov M. Popova E. Tsvetanska Robert G. Grenell J. J. Izquierdo V. H. Mark Joseph Germana N. Zill William P. Paré Joseph E. O. Newton George C. Offutt Walter Ehrlich Joseph E. D. Newton Julij Tosef J. Perez-Cruet Chester R. Wilpizeski John F. Lontz Andrew Livingston Joseph W. Cullen Samuel A. Corson Herman R. Weed Elizabeth O. Corson O. D. Murphree Paul N. Morgan Ruth Jarman J. Antal T. A. Ban J. V. Ananth H. E. Lehmann A. Ulric Moore Richard H. Barnes Wilson G. Pond 《Integrative psychological & behavioral science》1970,5(3):185-193
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INNATENESS, EXPERIENCE, AND MUSIC PERCEPTION 总被引:2,自引:0,他引:2
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Immunoreactivity of the immediate early gene c-fos was used to investigate changes in the activity of brainstem neurons in response to acute stressors like immobilization, formalin-induced pain, cold exposure, hemorrhage and insulin-induced hypoglycemia. Different stressors induced Fos-like immunoreactivity in different pontine and medullary neurons. A single, 3 hour immobilization was found to be a very strong stimulus that activated brainstem catecholaminergic (tyrosine hydroxylase-immunopositive) neurons and cells in the raphe and certain pontine tegmental nuclei, as well as in the reticular formation. Pain, induced by a subcutaneous injection of formalin was also effective on catecholamine-synthesizing neurons and on others cells in the nucleus of the solitary tract. Cold exposure activated cells mainly in the sensory spinal trigeminal and parabrachial nuclei and in the so-called "pontine thermoregulatory area". Moderate Fos-like immunoreactivity was induced by a hypotonic (25%) hemorrhage in medullary catecholaminergic neurons, the nucleus of the solitary tract and the Barrington nucleus. Among stressful stimuli used, insulin-induced hypoglycemia elicited the smallest Fos activation in the lower brainstem. The present observations indicate that different stressors may use different neuronal pathways in the central organization of the stress response. 相似文献
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Inhibition of protein synthesis by anisomycin for a short duration impairs memory of a one-trial inhibitory avoidance task in rats. Memory of escape conditioning involving eight trials is disrupted only if the duration of protein synthesis is prolonged by repeated injections. In marked contrast, olfactory memory of rats trained on two odor discriminations is not affected by anisomycin even if the duration of inhibition is prolonged and the number of trials is reduced to a minimum. In previous work, leupeptin, a thiol proteinase inhibitor, was shown to impair olfactory discrimination learning, but left inhibitory and avoidance conditioning intact. Together, these results provide a pharmacological double dissociation of memory, and suggest that the same chemistries, or mixtures of chemistries, may not be involved in all types of memory. 相似文献