Microdialysis administration of vasopressin and vasopressin antagonists into the septum during pole-jumping behavior in rats.

Wistar rats (n = 95) were trained in a pole-jumping apparatus (10 trials/session/day) to investigate the involvement of centrally and peripherally released endogenous AVP in their acquisition rate and to examine the feasibility of the microdialysis technique for the administration of peptides during a behavioral test. After session 1, a microdialysis probe was implanted into the septum; during sessions 2 and 3 the probe was perfused with artificial cerebrospinal fluid (aCSF) alone or containing either AVP (delivered amount via the probe: 0.2 ng) or the V1 (d(CH2)5Tyr(Me)AVP, 5.0 ng) or the V2/V1 (d(CH2)5-D-Tyr(Et)VAVP, 5.0 ng) antagonist. Administration of AVP via microdialysis into the septum failed to alter the acquisition rate of pole jumping. Also, ip application of both hypertonic saline and the AVP V1 antagonist (10 micrograms) in another experiment failed to show a significant effect upon behavior. Septal administration of the V1 or the V2/V1 antagonist via microdialysis, however, produced a significantly impaired performance. The results indicate that AVP release within the septum is involved in the acquisition of pole-jumping behavior probably mediated by the V1 receptor subtype. An additional involvement of the V2 receptor subtype, however, cannot be entirely excluded. The microdialysis technique proved to be a potent tool to administer substances concomitantly with behavioral tests.     

Was sind “ek-statische Maschinen”? (Gedanken aus und zu: M. K. Mamardašvili,Wissenschaft und Kultur)

Ohne ZusammenfassungM. K. Mamardavili, Nauka i kul'tura, inMetodologieskie problemy istorikonaunych issledovanij, M., Nauka, 1982, str. 38–58. Zitate aus diesem Aufsatz werden im Text mit der in Klammern gesetzten Seitenzahl ausgewiesen.     

Dispositional and situational moderators of female and male causal attributions

To increase understanding of the relationships between gender and causal attributions, dispositional and situational variables were examined to determine if they affected causal attributions differently if the subjects were females or males. Four dispositional variables—locus of control, neuroticism, achievement motivation, and self-esteem—and five situational variables—expectancy of success, self-reported commitment, perceived productivity, perceived task complexity, and actual performance—were examined for their moderating effects on the gender-causal attributional relationships. The dispositional variables did not moderate any causal relationships. By comparison, four situational variables—performance, commitment, productivity, and complexity—moderated at least one of the gender-attribution relationships. It was concluded that more attention should be directed to the identification of situational moderators.     

Intra- and interindividual relationships between elation-depression and desire for excitement

This study examined the relationship between elation-depression and desire for excitement on both intra- and interindividual levels. It was hypothesized that there would be a positive linear relationship between elation and desire for tranquillity These intraindividual hypotheses received strong support. This support would suggest that radical incongruities between activity demands and mood preparedness are often painful and would imply that in order for mood alteration to be successful it must take place gradually It was also hypothesized that characteristic level of elation-depression would be positively related to mean ratings of desire for excitement, positively related to score on a desire for excitement test, and negatively related to mean ratings of desire for tranquillity These interindividual hypotheses were not supported. Although it is probably most reasonable to accept the lack of correspondence between intra- and interindividual results, the operation of social comparison effects and social desirability bias may have obscured the predicted interindividual relationships     

Effects of decision strategy and number of openings on employment selection decisions

The purpose of this study was to explore the impact of two factors—decision strategy and the number of openings—on selection decisions. Two hundred graduate and undergraduate students participated in a human resource employment screening simulation. Decision strategy was varied by having candidates evaluate resumes and letters of application for 20 candidates one-at-a-time (sequentially) or all at once (simultaneously). The number of position openings was either one or three. Decision strategy affected the number of candidates accepted, acceptance threshold, and decision time. The number of openings affected selection decisions in the simultaneous but not the sequential context. Implications of these results for selection processes are discussed.     

Does symptomatic schizophrenia exist?

The question if there are "symptomatic schizophrenias" has been discussed since the 20s. Schizophrenic psychoses caused be definable and well known brain diseases are presented. All schizophrenic symptoms and syndromes, the first rank symptoms (K. Schneider) too, occur in somatically founded psychoses. The group of paroxysmal transition syndromes in the sense of aura prolongata (continua) and the episodic schizophrenic psychoses in psychomotor epilepsy may be a model for the schizophrenia research. Vital threatening, so-called pernicious catatonic schizophrenias are found on the basis of infectious brain diseases, sometimes only diagnosed in autopsy. Beside acute and reversible symptomatic schizophrenic psychoses there are, even if rarely, recurrent and chronic courses of symptomatic schizophrenias. That certain conditions for the developing of symptomatic schizophrenias are rarely realised, could be an explanation for their rarity. Some findings indicate that the limbic system is significant for symptomatic (and idiopathic) schizophrenic psychoses and the pre- and postpsychotic basic stages determined by dynamic and cognitive basic symptoms, which are phenomenologically very similar to aura symptoms released by stereoelectroencephalographic depth recordings (Wieser). The characteristic features of marked fluctuation, discontinuity and insteadiness of the cognitive thought, perception, psychomotor and cenesthetic phenomena do not speak against an organic brain disorder provided that the traditional process hypothesis is abandoned in favor of a neurobiochemic disorder, fluctuating on its part depending on endogenous as well as psychic-reactive factors.     

Text comprehension in aphasia

The semantic and pragmatic strategies in the comprehension of spoken texts are investigated in four subgroups of aphasic patients and in normal and brain-damaged controls. Short texts of similar linguistic structure were read to the subjects, who were required to choose the picture, from a multiple choice set of five, that was appropriate to the story. Besides a picture showing the main event of the story, one picture depicted the literal sense of a metaphorical comment, and the others misrepresented semantic functions expressed in the text. With respect to these types of responses, both aphasics and controls exhibited the same pattern of reaction. It is concluded that the redundancy of texts makes up for the difficulties aphasics have in comprehending isolated words and sentences.     

Simulation of Preference Information in an Interactive Reference Point‐Based Method for the Bi‐Objective Inventory Routing Problem

In the research area of multiple criteria decision making, very few publications exist that explicitly design the simulation of a decision maker (DM) in an interactive approach. For this reason, we outline some methods widely used in the literature to identify common assumptions of simulating the DM's responses and the required input preference information. Our paper aims at covering the identified gap by introducing experimental concepts. Such concepts are used for theoretical analyses of a combined search‐and‐decision‐making procedure. Simulating the DM is a fruitful idea because the algorithm can be tested without integrating a human decision maker. Finally, we conduct experiments based on the proposed settings for a multiobjective inventory routing problem, which is a relevant and challenging logistic problem. Copyright © 2014 John Wiley & Sons, Ltd.