Inhibition of the LH Surge by Restraint Stress in Cyclic Rats: Studies on the Role of GABAA and GABAB Receptors

There is evidence that stress can alter the activity in the brain of gamma-aminobutyricacid (GABA), a neurotransmitter that has been implicated in the regulation of LH secretion. In the present study the role of GABA in the restraint stress-induced inhibition of the LH surge was investigated in the intact cyclic rat. Intracerebroventricular (icv) administration of the GABAA receptor agonist muscimol (0.1, 0.5 or 1 μg) 5 min before the presumed onset of the pro-oestrous LH surge (at 0900 h) caused a dose dependent suppression of the surge. A single dose of the GABAB receptor agonist baclofen (1 μg; icv) injected at 0855 h postponed the onset of the LH surge, and repeated injections at 0855 and 1130 h suppressed the surge. These data indicate that GABA-ergic activity in the brain can inhibit the LH surge in the cyclic rat via GABAA and GABAB receptors. Pro-oestrous rats were subjected to 5 hrs of restraint starting at 0855 h. Pretreatment with the GABAA receptor antagonist bicuculine (1 μg; icv) at 0840, 0940 and 1040 h or pretreatment with the GABAB receptor antagonist phaclofen (10 μg; icv) at 0840 h were ineffective in preventing the restraint-induced inhibition of the LH surge. The results suggest that GABAA and GABAB receptors are not involved in the inhibitory effect of restraint stress on the LH surge.     

Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

Perceiving Aggression from Facial Structure: Further Evidence for a Positive Association with Facial Width‐to‐Height Ratio and Masculinity,but not for Moderation by Self‐Reported Dominance

Recent work has indicated that individual differences in facial structure are linked to perceptions of aggressiveness. In particular, the relative width of a face [facial width‐to‐height ratio (fWHR)] has been suggested to be a reliable cue to aggressive behaviour, at least in men. Additionally, facial masculinity has been associated with perceptions of dominance, a close proxy of aggressiveness. In two studies, we assessed the robustness of this link using faces transformed along these vectors in men (Studies 1 and 2) and women (Study 2). Additionally, we examined whether individual differences in self‐reported dominance of perceivers moderated this association in order to extend previous work indicating that own dominance affects perception of such behaviour in others. Results indicated that both male and female faces with increased fWHR and increased facial masculinity were perceived as more aggressive. However, we found no systematic evidence for moderating effects of self‐reported dominance on the perception of aggression in others. Taken together, these results further support the robustness of fWHR and facial masculinity as cues to aggressiveness but question whether observers' own dominance moderates their perception of these cues in others. Copyright © 2013 European Association of Personality Psychology     

大学二年级学生人际宽恕与报复心理及其与抑郁的关系研究

采用沉思量表、报复动机量表、宽恕倾向量表、宽恕态度量表和流调中心用抑郁量表对236名大二学生进行问卷调查,综合探讨大学生人际宽恕和报复心理及其与抑郁的关系。研究发现:(1)男大学生的报复倾向显著高于女大学生。(2)宽恕倾向与报复倾向及对侵犯的沉思程度显著负相关。沉思程度和抑郁显著正相关。(3)沉思程度和宽恕倾向对抑郁分别具有显著的正向和负向的预测作用。(4)大学生的宽恕倾向和宽恕态度的相互作用以及宽恕倾向和报复倾向之间的交互作用对抑郁均没有显著预测作用。     

Passive avoidance behavior in rats after electroconvulsive shock: facilitative effect of response retardation.

Rats were trained in a one-trial passive avoidance task and then were submitted to electroconvulsive shock (ECS) or to sham ECS. Twenty-four hours later they were tested for retention, with the door opened either immediately or 30 sec after the beginning of the test. Rats initially forced to avoid for 30 sec continued to avoid for the entire test, but the others had the usual low step-through latencies seen with ECS-treated animals. Activity measures for those animals stepping through differentiated groups having received footshock from those not having footshock and ECS. A retest 5--10 min later showed "recovery" in the amnestic animals and continued avoidance behavior for those that avoided on the first test. Results are taken as evidence that ECS effects are not on memory storage but on the capacity of the animal to organize information effectively and quickly in order to produce an adaptive response.     

Information processing bias against emotional facial expressions in social anxiety

The present study examined whether information processing bias against emotional facial expressions is present among individuals with social anxiety. College students with high (high social anxiety group; n  = 26) and low social anxiety (low social anxiety group; n  = 26) performed three different types of working memory tasks: (a) ordering positive and negative facial expressions according to the intensity of emotion; (b) ordering pictures of faces according to age; and (c) ordering geometric shapes according to size. The high social anxiety group performed significantly more poorly than the low social anxiety group on the facial expression task, but not on the other two tasks with the nonemotional stimuli. These results suggest that high social anxiety interferes with processing of emotionally charged facial expressions.     

Sport participation and stress among women and men

ObjectivesIn-depth analysis of the relationship between sports participation and stress among adult women and men.Design644 women and 783 men, 20–65 years, from the SPAH Flemish-Policy-Research-Centre, reported data on participation in favourite sports and mental health.MethodGender-specific multiple MANOVAs with stress appraisal and the stress response of emotional distress as dependent variables, and participation in 15 different types of sports as independent variables, including effect sizes (Cohen’s d) per sport-type.ResultsVery little difference in perceived-stress and emotional-distress existed in women and men who participated in different sport-types, suggesting that “one-activity-fits-all recommendations” are likely inappropriate. Different sports are suitable for different individuals, and it is important that one finds the sport that suits one best. Conversely, significant associations between participation in walking and in meditation sports manifested with both stress appraisal and emotional distress among women, and significant associations between participation in ball games and in water sports manifested with emotional distress among men.ConclusionsThe paper gathered substantial comprehensive insight and connected its quantitative data to existing qualitative data, presenting stimulating theoretical arguments. Sport-type related variations in the physical activity – mental health relationship were analyzed, based on the theory of mindful movement and the complexity paradigm identifying 3 coordinates on which the physical activity – mental health complexity unravels, based on: activity domains, mental health dimensions, and individual characteristics. The mindful movement theory proposes an underlying mechanism that could explain the positive physical activity – mental health relationship, and the complexity paradigm provides basis for creating a workable definition for ther concept of mindful physical activity.     

Toward an Integration of Interpersonal Risk Models of Depression and Cognitive‐Behaviour Therapy

Empirical research has increasingly focused on interpersonal variables associated with the development and maintenance of depression. This article outlines some key interpersonal risk factors for depression, including anxious attachment, sociotropy, excessive reassurance seeking, interpersonal stress generation, reduced social support, social skills deficits, and social avoidance. Recommendations are made for how cognitive‐behavioural therapy may be adapted to address such factors. Specifically, suggestions are offered for how cognitive and behavioural interventions, such as cognitive restructuring, behavioural activation, behavioural experiments, and skills training, may be used with depressed clients to promote positive relationships and reduce maladaptive interpersonal behaviours.