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Impaired verb fluency: a sign of mild cognitive impairment 总被引:3,自引:0,他引:3
We assessed verb fluency vs. noun and letter-based fluency in 199 subjects referred for cognitive complaints including Subjective Cognitive Impairment, Mild Cognitive Impairment, and Alzheimer's disease. ANCOVAs and factor analyses identified verb, noun, and letter-based fluency as distinct tasks. Verb fluency performance in Mild Cognitive Impairment differed significantly from Subjective Cognitive Impairment and Alzheimer's disease. Reduced verb fluency thus appears to be a linguistic marker for incipient dementia. One possibility is that the verb fluency deficit in Mild Cognitive Impairment results from degenerative processes known to occur in the parahippocampal region. 相似文献
2.
Christina Grape Maria Sandgren Lars-Olof Hansson Mats Ericson T?res Theorell 《Integrative Physiological and Behavioral Science》2003,38(1):65-74
This study explored the possible beneficial effects of singing on well-being during a singing lesson. Eight amateur (2m, 6f, age 28-53 yrs) and eight professional (4m, 4f, age 26-49 yrs) singers who had been attending singing lessons for at least six months were included. Continuous ECG was recorded and computerized spectral analysis was performed. Serum concentrations of TNF-alpha, prolactin, cortisol, and oxytocin were measured before and 30 min after the lesson. Five visual analogue scales (VAS, sad-joyful, anxious-calm, worried-elated, listless-energetic, and tense-relaxed) were scored before and after the lesson. In addition, a semi-structured interview was performed. Heart rate variability analyses showed significant changes over time in the two groups for total power, and low and high frequency power. Power increased during singing in professionals, whereas there were no changes in amateurs. This indicates an ability to retain more "heart-brain connection." i.e., more cardio-physiological fitness for singing in professional singers, compared to amateur singers. Serum concentration of TNF-alpha increased in professionals after the singing lesson, whereas the concentration in amateurs decreased. Serum concentrations of prolactin and cortisol increased after the lesson in the group of men and vice versa for women. Oxytocin concentrations increased significantly in both groups after the singing lesson. Amateurs reported increasing joy and elatedness (VAS), whereas professionals did not. However, both groups felt more energetic and relaxed after the singing lesson. The interviews showed that the professionals were clearly achievement-oriented, with focus on singing technique, vocal apparatus and body during the lesson. The amateurs used the singing lessons as a means of self-actualization and self-expression as a way to release emotional tensions. In summary, in this study, singing during a singing lesson seemed to promote more well-being and less arousal for amateurs compared to professional singers, who seemed to experience less well-being and more arousal. 相似文献
3.
The aim of the present study was to evaluate the usefulness of Barkley’s (1997a) model of inhibition and executive functioning in describing the deficits associated with Attention Deficit Hyperactivity Disorder (ADHD). Besides group differences, the present study addressed the question of independent effects of inhibition and the other executive functions in discriminating between children with ADHD and controls and how well, in terms of sensitivity and specificity, these measures can classify the children into the correct group. The results showed that children with ADHD differed significantly from controls with regard to measures of inhibition as well as all other executive function measures, except repetition of hand movements. In logistic regression models, three different measures tapping inhibition, working memory and emotion regulation were shown to be significant independent predictors of group membership. The sensitivity for these three variables as a set was 76.2, the specificity was 90.5, with a total of 86% of the sample correctly classified. When excluding the parental rating of emotion regulation, the overall classification rate decreased some, but was still relatively high in comparison with previous studies within this area of research. 相似文献
4.
Lekander M von Essen J Schultzberg M Andreasson AN Garlind A Hansson LO Nilsson LG 《Scandinavian journal of psychology》2011,52(3):229-235
Increasing evidence suggests a role of the immune system in modulation of cognition, but details on affected memory systems are largely lacking. We therefore aimed to study the relation between selected cytokines and subsets of memory, and the impact of age in these relations. From a random population-based sample (the Betula Prospective Cohort Study), 298 women (age 45-90) were studied in terms of episodic recall and recognition, semantic fluency and knowledge, and prospective memory. Circulating cytokines of relevance for cognition and aging were measured with ELISA. Levels of interleukin (IL)-6 and sIL-2R were significantly and negatively associated with most cognitive variables, while the opposite was true for IL-1β. Age shared substantial variance with both cytokines and memory, and turned most correlations non-significant when controlled for together with education, BMI and presence of disease. Interactions between age and cytokines were further analyzed in multiple regressions. For IL-6, significant negative interactions with age were found for semantic fluency (p<0.05) and prospective memory (p<0.01), and for sIL-2R in predicting semantic knowledge (p<0.05), indicating an increased negative impact of these cytokines on memory with increasing age. In conclusion, the study indicates a relation between cytokines and memory that appears to be largely mediated by age, and supports the suggestion that cytokine dysregulation with higher age may interact with cognitive aging. 相似文献
5.
How well do measures of inhibition and other executive functions discriminate between children with ADHD and controls? 总被引:4,自引:0,他引:4
The aim of the present study was to evaluate the usefulness of Barkley's (1997a) model of inhibition and executive functioning in describing the deficits associated with Attention Deficit Hyperactivity Disorder (ADHD). Besides group differences, the present study addressed the question of independent effects of inhibition and the other executive functions in discriminating between children with ADHD and controls and how well, in terms of sensitivity and specificity, these measures can classify the children into the correct group. The results showed that children with ADHD differed significantly from controls with regard to measures of inhibition as well as all other executive function measures, except repetition of hand movements. In logistic regression models, three different measures tapping inhibition, working memory and emotion regulation were shown to be significant independent predictors of group membership. The sensitivity for these three variables as a set was 76.2, the specificity was 90.5, with a total of 86% of the sample correctly classified. When excluding the parental rating of emotion regulation, the overall classification rate decreased some, but was still relatively high in comparison with previous studies within this area of research. 相似文献
6.
Christina Grape Maria Sandgren Lars-Olof Hansson Mats Ericson Töres Theorell 《Integrative psychological & behavioral science》2002,38(1):65-74
This study explored the possible beneficial effects of singing on well-being during a singing lesson. Eight amateur (2m, 6f,
age 28–53 yrs) and eight professional (4m, 4f, age 26–49 yrs) singers who had been attending singing lessons for at least
six months were included. Continuous ECG was recorded and computerized spectral analysis was performed. Serum concentrations
of TNF-alpha, prolactin, cortisol, and oxytocin were measured before and 30 min after the lesson. Five visual analogue scales
(VAS, sad-joyful, anxious-calm, worried-elated, listless-energetic, and tense-relaxed) were scored before and after the lesson.
In addition, a semi-structured interview was performed.
Heart rate variability analyses showed significant changes over time in the two groups for total power, and low and high frequency
power. Power increased during singing in professionals, whereas there were no changes in amateurs. This indicates an ability
to retain more “heart-brain connection,” i.e., more cardio-physiological fitness for singing in professional singers, compared
to amateur singers. Serum concentration of TNF-alpha increased in professionals after the singing lesson, whereas the concentration
in amateurs decreased. Serum concentrations of prolactin and cortisol increased after the lesson in the group of men and vice
versa for women. Oxytocin concentrations increased significantly in both groups after the singing lesson. Amateurs reported
increasing joy and elatedness (VAS), whereas professionals did not. However, both groups felt more energetic and relaxed after
the singing lesson. The interviews showed that the professionals were clearly achievement-oriented, with focus on singing
technique, vocal apparatus and body during the lesson. The amateurs used the singing lessons as a means of self-actualization
and self-expression as a way to release emotional tensions. In summary, in this study, singing during a singing lesson seemed
to promote more well-being and less arousal for amateurs compared to professional singers, who seemed to experience less well-being
and more arousal. 相似文献
7.
Reactions to third-party inequality were investigated in three experiments. In Experiment 1, 52 undergraduates allocated money between themselves and two others. Preferences for equal and unequal distributions were also rated. The results show that people are averse to inequalities between themselves and others, and to inequalities between others. Post-experimental ratings indicate that egocentric equality, third-party equality, and max–min preferences are important motives. The findings were replicated in Experiment 2, where 74 undergraduates allocated compensation for a previously conducted task, and in Experiment 3, where 112 participants rated preferences. In these experiments random determination of rewards to third parties altered participants’ behavior and preferences. The results indicated that random determination decreases the importance of all fairness motives while increasing the importance of monetary payoff. While people still care about economic equality under these conditions, contextual factors, such as perceived responsibility for unfair outcomes, seem to alter the impact of fairness. 相似文献
8.
Lilianne Nyberg Gunilla Bohlin Lisa Berlin Lars‐Olof Janols 《Infant and child development》2003,12(2):145-158
In light of the previously found overlap between Type A behaviour as measured by the Matthews Youth Test for Health (MYTH) and hyperactivity scales, the overall aim of this study was to clarify the standing of MYTH‐defined Type A behaviour relative to hyperactivity and Attention‐Deficit/Hyperactivity Disorder (ADHD), using observed task motivation and performance on a choice reaction‐time task, the Complex Reaction Time (CRT) measure. This study included 21 boys exhibiting Type A behaviour, 22 ADHD boys, 20 non‐clinically hyperactive boys, and 20 non‐hyperactive boys, between the ages of 6 and 13 years. It was proposed that a differentiation of constructs would be possible using observed task motivation if the MYTH were a discriminantly valid measure of Type A behaviour. Results showed that the MYTH‐defined Type A group differed from the clinically diagnosed ADHD group, although it was markedly similar to the non‐clinical hyperactive group, displaying comparable CRT performance and low level of task motivation. Type A behaviour correlated to CRT performance and task motivation in a way which was conceptually more indicative of hyperactivity than of Type A behaviour, which questions the validity of the MYTH as a measure of the Type A construct. The MYTH Impatience subscale was found to be particularly impure with regard to hyperactivity. Copyright © 2003 John Wiley & Sons, Ltd. 相似文献
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