Development and Pilot Testing of a Decision Aid for Genomic Research Participants Notified of Clinically Actionable Research Findings for Cancer Risk

Germline genomic testing is increasingly used in research to identify genetic causes of disease, including cancer. However, there is evidence that individuals who are notified of clinically actionable research findings have difficulty making informed decisions regarding uptake of genetic counseling for these findings. This study aimed to produce and pilot test a decision aid to assist participants in genomic research studies who are notified of clinically actionable research findings to make informed choices regarding uptake of genetic counseling. Development was guided by published literature, the International Patient Decision Aid Standards, and the expertise of a steering committee of clinicians, researchers, and consumers. Decision aid acceptability was assessed by self-report questionnaire. All 19 participants stated that the decision aid was easy to read, clearly presented, increased their understanding of the implications of taking up research findings, and would be helpful in decision-making. While low to moderate levels of distress/worry were reported after reading the booklet, a majority of participants also reported feeling reassured. All participants would recommend the booklet to others considering uptake of clinically actionable research findings. Results indicate the decision aid is acceptable to the target audience, with potential as a useful decision support tool for genomic research participants.     

HIV prevention with persons with mental health problems

The HIV seroprevalence rate among persons with mental health problems (PMHP) is substantially higher than that of the general population in the United States. This study examines the efficacy over 12 months of an HIV prevention program with 99 individuals attending outpatient mental health clinics who were randomly assigned to receive either: (a) a seven-session, small-group intervention of Project LIGHT (Living in Good Health Together); or (b) a one-session video intervention. Regression analyses of data from 87% of the sample interviewed at 1-year follow-up revealed that intervention group membership was associated with significantly fewer sexual risk acts. A significant intervention effect for condom use was found for 72% of the sample who were African American, but not for Latino or Caucasian participants. Results from this study suggest that HIV risk reduction groups such as Project LIGHT may have utility in public mental health care settings.     

全球流感大流行与共建和谐社会

科学家预测:新一轮流感大流行不可避免。通过总结历史教训,分析目前可能引起流感大流行的原因,展开预防流感大流行与共建和谐社会关系的讨论。     

数字式肌电显示仪及其在体育中的应用

本文介绍数字式肌电显示仪。由微电极检测得到的肌电信号经过放大器之后被本仪器以数字形式显示出来,由于其具有对输出量的保持以及提供不同的展示肌电值的时间间隔的功能,它可以用于估计和分析人体的紧张程度。本仪器已用于国家射击队的心理训练。     

对语义网络中概念非类属关系的实验研究

本研究包括三个实验。实验一在混和呈现条件下比较被试对隐喻句和类属句的加工时问,发现可理解性高的隐喻句的R_T不比类属句的慢。实验二在分组呈现条件下比较被试加工隐喻句与类属句的速度,结果与实验一基本相同。实验一、二中还发现类属概念的层次与语义加工时间没有必然联系。实验三比较了隐喻句对三类概念的启动作用,发现隐喻对自身的语义特征概念有明显的启动作用。根据三个实验的结果,我们提出了一种称为特征联结的语义网络结构模型。     

Birth Defects,Causal Attributions,and Ethnicity in the National Birth Defects Prevention Study

In order to translate research findings into effective prevention strategies, it is important to understand people's beliefs about the causes of poor health outcomes. However, with the exception of knowledge and beliefs about folic acid supplementation, little is known regarding women's causal attributions women regarding birth defects. We employed Attribution Theory constructs to analyze open-text interview responses from 2,672 control mothers in the National Birth Defects Prevention Study who gave birth in 1997–2005. Common themes included use of alcohol, tobacco, illicit drugs, and medications during pregnancy. Stress and emotional upset were also suggested as possible causes of birth defects. Genetic- and heredity-related responses were more likely to be mentioned by Asian/Pacific Islander women compared to non-Hispanic Whites. Hispanic women were less likely to suggest several specific possible teratogens, such as paint, pesticides, or other chemicals, but were more likely to suggest events occurring during childbirth. Differences also emerged among ethnic groups for theoretical constructs, although most responses were categorized as controllable, changeable over time, and with an internal locus of causality.