Regional cerebral glucose metabolism in aphemia: A case report

Local cerebral metabolism was determined in a patient suffering aphemia following cerebral infarction using the 18FDG-PET technique. The syndrome was characterized by profound ictal nonfluency with sparing of other language functions. Speech subsequently improved so that content and grammar were appropriate but mild dysprosody persisted. Conventional CT showed no lesion of the left hemisphere while PET revealed a discrete focus of hypometabolism on the left which partially resolved on serial studies. The metabolic lesion could be localized to the region of the inferior precentral gyrus and the adjacent subcortical space.     

RESOLUTION OF LEXICAL AMBIGUITY BY EMOTIONAL STATE

Abstract— The role of emotion in the resolution of lexical ambiguity was investigated. Happy and sad subjects listened to a list of words that included homophones that had happy and neutral meanings (eg., presents-presence ) and homophones that had sad and neutral meanings (eg., mourning-morning ). Words were presented every 3 s, and subjects wrote down the words, as they heard them (Meaning could be identified by spelling in all cases). An interaction between emotional state and homophone category was observed. Sad subjects were more likely to write down sad meanings than were happy subjects. Results are discussed with reference to the literatures on both emotion and lexical access.     

The Structure of Internalizing Disorders in Middle Childhood and Evidence for Personality Correlates

The current multi-method multi-informant investigation compared the fit of three competing models of internalizing problems in middle childhood: (1) a unitary factor model, (2) a two-factor model corresponding to the DSM-IV Anxiety/Depression distinction, and (3) a two-factor model corresponding to the Fear/Distress distinction observed in structural studies of adult psychopathology (Krueger Archives of General Psychiatry, 56:921-926, 1999); Slade and Watson Psychological Medicine, 36:1593-1600, 2006). In total, 346 youths (mean age = 9.51, SD = .78) and their adult caregivers (344 mothers, 227 fathers) reported on childhood internalizing symptoms and personality traits. Confirmatory factor analyses revealed adequate to good fit indices for all three models, although the unitary factor model provided the most parsimonious summary of the data. Although the structural analyses suggested that internalizing symptom subfactors were not clearly differentiated in middle childhood, hierarchical regression analyses revealed that personality dimensions uniquely predicted the Anxiety/Fear and Depression/Distress disorders. These results suggest that personality correlates differentiate childhood psychopathology structure before it is manifest at the symptom level.     

Anxiety,Immigration, and the Search for Information

In this article, we use the issue of immigration to explore the role of anxiety in responses to political appeals. According to previous literature, anxiety motivates citizens to learn and pay more attention to news coverage. Literature in psychology demonstrates that anxiety is associated with a tendency to pay closer attention to threatening information. We predict that anxious citizens will seek more information but that they will seek out and be attracted to threatening information. In an experiment, we induce anxiety about immigration and then subjects have the opportunity to search for additional information in a website designed to mimic online news sources. The website has both immigration and nonimmigration stories, and the immigration stories are split between threatening coverage and nonthreatening coverage. We find that anxious subjects exhibit biased information processing; they read, remember, and agree with threatening information.     

Panic disorder in the families of patients with normal coronary arteries and non-fear panic disorder.

Patients with non-fear panic disorder (NFPD) meet DSM-III-R criteria for panic disorder, but do not report subjective fear or anxiety. Although apparently common in medical settings, this controversial group is in need of further diagnostic validation. This study assessed family history of panic disorder in patients with chest pain and normal coronary arteries (CP/NCA) and either NFPD, panic disorder with fear, or no panic. It was hypothesized that the two panic disorder groups would have similar, elevated rates of panic disorder in their first-degree relatives, compared to patients without panic. The results support the hypothesis; about 17% of the first-degree relatives of both NFPD and panic disorder patients were diagnosable with panic disorder according to proband interviews, whereas only 4.6% of the first-degree relatives of patients without panic were so diagnosable. These results support the diagnostic validity of NFPD in CP/NCA patients, because such patients had a family history of panic disorder similar to patients with a more classical panic disorder presentation. The lack of fear symptoms and behavior in NFPD may cause panic disorder to be overlooked as a potential cause of somatic symptoms in patients with no medical explanation for their condition.     

Panic attacks without fear: An overview*

‘Non-fearful panic disorder’ (NFPD) is a condition that meets DSM III-R criteria for panic disorder but lacks a report of subjective fear or anxiety. Presenting the first comprehensive overview of this issue, the authors describe studies investigating a wide range of apparently overlapping phenomena including NFPD, ‘somatically expressed panic’, ‘non-cognitive panic’, ‘alexithymic panic’, ‘non-clinical panic’, and ‘masked anxiety’. The review shows that such conditions account for from 20 to 40% of the panic disorder found in various medical populations, and that this group resembles conventional panic disorder in cross-sectional comparisons. We emphasize that a ‘triple-response’ model of anxiety is consistent with our conclusion that NFPD should be conceptualized as a panic disorder subtype. Finally, we discuss unresolved issues regarding the construct and predictive diagnostic validity of NFPD.