Cocaine-induced brainstem seizures and behavior.

A variety of abnormal sensory/motor behaviors associated with electrical discharges recorded from the bilateral brainstem were induced in adult WKY rats by mechanical (electrode implants) and DC electrical current stimulations and by acute and chronic administration of cocaine. The electrode implant implicated one side or the other of the reticular system of the brainstem but subjects were not incapacitated by the stimulations. Cocaine (40 mg/kg) was injected subcutaneously for an acute experiment and subsequent 20 mg/kg doses twice daily for 3 days in a chronic study. Cocaine generated more abnormal behaviors in the brainstem perturbation group, especially the electrically perturbated subjects. The abnormal behaviors were yawning, retrocollis, hyperactivity, hypersensitivity, "beating drum" behavior, squealing, head bobbing, circling, sniffing, abnormal posturing, and facial twitching. Shifts in the power frequency spectra of the discharge patterns were noted between quiet and pacing behavioral states. Hypersensitivity to various auditory, tactile, and visual stimulation was present and shifts in the brainstem ambient power spectral frequency occurred in response to tactile stimulation. These findings suggest that the brainstem generates and propagates pathological discharges that can be elicited by mechanical and DC electrical perturbation. Cocaine was found to activate the discharge system and thus induce abnormal behaviors that are generated at the discharge site and at distant sites to which the discharge propagates. Cognitive functions may also be involved since dopaminergic and serotonergic cellular elements at the brainstem level are also implicated.     

Development of perceived adolescent relationship scale

The purpose of the present study was to develop an easily administered scale to assess adolescents' perceptions of both their own social competence and social participation in relationships. Six items were used to generate two factors that accounted for about 68% of the variance.     

Interhemispheric transfer in schizophrenics, depressives, and normals with schizoid tendencies

Although several studies suggest that schizophrenics suffer from an impairment in the interhemispheric transfer (IHT) of information, methodological weaknesses in these studies preclude clear interpretation of their results. This study addresses these criticisms in order to provide a clearer test of the IHT theory. Schizophrenics, depressives, normal controls, and normals with schizoid tendencies were assessed on five measures of IHT (verbal and nonverbal dichotic listening, intermanual transfer, bimanual block design, finger sequence repetition) and two measures of unilateral hemispheric processing (lateral eye movements, auditory thresholds). Results consistently failed to support an IHT deficit interpretation of schizophrenia. Schizoid normals had a significantly greater right-ear advantage on verbal dichotic listening than both psychiatric groups, a result suggesting enhanced left-hemisphere activation in schizoid normals. It is concluded that the IHT theory requires stronger empirical substantiation than has been obtained to date to warrant further consideration as a central theory of schizophrenia.     

ACQUISITION,GENERALIZATION, AND MAINTENANCE OF QUESTION-ANSWERING SKILLS IN AUTISTIC CHILDREN

We conducted an investigation to evaluate the effects of a training strategy for teaching autistic students generalized responses to three forms of wh— questions (what, how, and why). Students were taught, using modeling and reinforcement procedures, to answer questions with magazine pictures as the referents. Each question form was divided into two or more subcomponents reflective of common social usage and was taught within the context of a modified multiple probe design across subcomponents. Following acquisition of each subcomponent, generalization to natural context and storybook questions was assessed; additional probes were conducted to assess responding over time and whether acquisition of responses to questions promoted question-asking skills. Results showed that the picture training procedure was effective in teaching a generalized response to questions for which the relevant cue was visible, whereas specific generalization programming was required for situations in which the relevant cue was not visible. All acquired responses were durable over time.     

Instance-based categorization: Automatic versus intentional forms of retrieval

Two experiments are reported which attempt to disentangle the relative contribution of intentional and automatic forms of retrieval to instance-based categorization. A financial decision-making task was used in which subjects had to decide whether a bank would approve loans for a series of applicants. Experiment 1 found that categorization was sensitive to instance-specific knowledge, even when subjects had practiced using a simple rule. L. L. Jacoby’s (1991) process-dissociation procedure was adapted for use in Experiment 2 to infer the relative contribution of intentional and automatic retrieval processes to categorization decisions. The results provided (1) strong evidence that intentional retrieval processes influence categorization, and (2) some preliminary evidence suggesting that automatic retrieval processes may also contribute to categorization decisions.     

The time course of recognition of novel melodies

Seven experiments explored the time course of recognition of brief novel melodies. In a continuous-running-memory task, subjects recognized melodic transpositions following delays up to 2.0 min. The delays were either empty or filled with other melodies. Test items included exact transpositions (T), same-contour lures (SC) with altered pitch intervals, and different-contour lures (DC). DCs differed from Ts in the pattern of ups and downs of pitch. With this design, we assessed subjects’ discrimination of detailed changes in pitch intervals (T/SC discrimination) as well as their discrimination of contour changes (T/DC). We used both artificial and “real” melodies. Artificial melodies differed in conformity to a musical key, being tonal or atonal. After empty delays, T/DC discrimination was superior to T/SC discrimination. Surprisingly, after filled delays, T/SC discrimination was superior to T/DC. When only filled delays were tested, T/SC discrimination did not decline over the longest delays. T/DC performance declined more than did T/SC performance across both empty and filled delays. Tonality was an important factor only for T/SC discrimination after filled delays. T/DC performance was better with rhythmically intact folk melodies than with artificial isochronous melodies. Although T/SC performance improved over filled delays, it did not overtake T/DC performance. These results suggest that (1) contour and pitch-interval information make different contributions to recognition, with contour dominating performance after brief empty delays and pitch intervals dominating after longer filled delays; (2) a coherent tonality facilitates the encoding of pitch-interval patterns of melodies; and (3) the rich melodic—rhythmic contours of real melodies facilitate T/DC discrimination. These results are discussed in terms of automatic and controlled processing of melodic information.     

The effect of mood and incentives on helping: Are there some things money can't buy?

Happy, guilty, and neutral mood states were induced in participants who were then provided with an opportunity to donate blood for free, to donate in exchange for $5, or to choose between donating for free or for $5. As expected, there was a significantly higher incidence of helping when subjects felt happy and guilty as opposed to emotively neutral. Contrary to predictions, helping was unaffected by the type of incentive (donate for $5, donate for free, choose $5/free) subjects were offered in interaction with their mood state. However, the type of incentive did seem to influence the postdonation emotions of subjects: Guilty subjects who donated for money felt significantly less guilty following donation than prior to it and happy subjects felt more self-altruistic (kind and generous) following donation when they helped for free. The results are discussed in terms of Cialdini's negative state relief model (for negative moods) and the intrinsic qualities of helping (for positive moods).     

On Turkey Identification

As human relations skills are more widely taught and used, they are inevitably misused as well, often by some particularly fowl aggressors. This article is intended as a brief self-defense course identifying those who undergo this strange, but usually temporary, metamorphosis into “turkeys.” It provides a rough categorization of subspecies with their identifying characteristics and a proposal for return to personhood.