Inhibition of the LH Surge by Restraint Stress in Cyclic Rats: Studies on the Role of GABAA and GABAB Receptors

There is evidence that stress can alter the activity in the brain of gamma-aminobutyricacid (GABA), a neurotransmitter that has been implicated in the regulation of LH secretion. In the present study the role of GABA in the restraint stress-induced inhibition of the LH surge was investigated in the intact cyclic rat. Intracerebroventricular (icv) administration of the GABAA receptor agonist muscimol (0.1, 0.5 or 1 μg) 5 min before the presumed onset of the pro-oestrous LH surge (at 0900 h) caused a dose dependent suppression of the surge. A single dose of the GABAB receptor agonist baclofen (1 μg; icv) injected at 0855 h postponed the onset of the LH surge, and repeated injections at 0855 and 1130 h suppressed the surge. These data indicate that GABA-ergic activity in the brain can inhibit the LH surge in the cyclic rat via GABAA and GABAB receptors. Pro-oestrous rats were subjected to 5 hrs of restraint starting at 0855 h. Pretreatment with the GABAA receptor antagonist bicuculine (1 μg; icv) at 0840, 0940 and 1040 h or pretreatment with the GABAB receptor antagonist phaclofen (10 μg; icv) at 0840 h were ineffective in preventing the restraint-induced inhibition of the LH surge. The results suggest that GABAA and GABAB receptors are not involved in the inhibitory effect of restraint stress on the LH surge.     

Injustice impairs self-regulation and affects food choice

Overweight and obesity are risk factors for a range of chronic diseases, many of them caused by excessive consumption of unhealthy foods and insufficient consumption of healthy foods. The present study aims to experimentally test the effect of being exposed to injustice on the intention to consume healthy and unhealthy foods, through self-regulation. We predicted that injustice decreases self-regulation which in turn increases the intention to consume unhealthy foods and decreases the intention to consume healthy foods. Undergraduate students (N = 175; 89% women; M_age = 24.28, SD = 7.36) were randomly exposed to a scenario describing an unjust or a just academic situation. In a subsequent allegedly unrelated task, participants were asked to indicate their intention to consume each of 26 food items (half depicting unhealthy foods and half healthy foods, random order) during the subsequent week. As expected, injustice decreased self-regulation which in turn increased the intention to consume unhealthy foods and decreased the intention to consume healthy foods. These results highlight the central importance of justice perceptions in the study of consumption and contribute to frame it in the study of the consequences of economic inequalities for nutrition.     

Sándor Ferenczi: From Clinical Turmoil to Theoretical Articulations

The article deals with concepts proposed by Sándor Ferenczi: confusion of tongues, disavowal and progressive trauma, illustrated by a clinical example, in which excessive life experiences deeply determined the psychic construction, compromising the integrity of the self-image and the potentiality of egoic capacities. We attempt to understand the uniqueness of the patient's history, and the ethical practice of deep analytic listening.     

Conditioned fear is modulated by D2 receptor pathway connecting the ventral tegmental area and basolateral amygdala

Excitation of the mesocorticolimbic pathway, originating from dopaminergic neurons in the ventral tegmental area (VTA), may be important for the development of exaggerated fear responding. Among the forebrain regions innervated by this pathway, the amygdala is an essential component of the neural circuitry of conditioned fear. The functional role of the dopaminergic pathway connecting the VTA to the basolateral amygdala (BLA) in fear and anxiety has received little attention. In vivo microdialysis was performed to measure dopamine levels in the BLA of Wistar rats that received the dopamine D(2) agonist quinpirole (1 μg/0.2 μl) into the VTA and were subjected to a fear conditioning test using a light as the conditioned stimulus (CS). The effects of intra-BLA injections of the D(1) antagonist SCH 23390 (1 and 2 μg/0.2 μl) and D(2) antagonist sulpiride (1 and 2 μg/0.2 μl) on fear-potentiated startle (FPS) to a light-CS were also assessed. Locomotor performance was evaluated by use of open-field and rotarod tests. Freezing and increased dopamine levels in the BLA in response to the CS were both inhibited by intra-VTA quinpirole. Whereas intra-BLA SCH 23390 did not affect FPS, intra-BLA sulpiride (2 μg) inhibited FPS. Sulpiride's ability to decrease FPS cannot be attributed to nonspecific effects because this drug did not affect motor performance. These findings indicate that the dopamine D(2) receptor pathway connecting the ventral tegmental area and the basolateral amygdala modulates fear and anxiety and may be a novel pharmacological target for the treatment of anxiety.     

Circulating leukocyte heat shock protein 70 (HSP70) and oxidative stress markers in rats after a bout of exhaustive exercise

A novel method to measure oxidative stress resulting from exhaustive exercise in rats is presented. In this new procedure we evaluated the erythrocyte antioxidant enzymes, catalase (CAT) and glutathione reductase (GR), the plasma oxidative attack markers, reactive carbonyl derivatives (RCD) and thiobarbituric reactive substances (TBARS). Muscular tissue damage was evaluated by monitoring plasma creatine kinase (CK) and plasma taurine (Tau) concentrations. Also, we monitored total sulphydryl groups (TSG) and uric acid (UA), and the level of the 70 kDa heat shock protein (HSP70) in leukocytes as a marker of oxidative stress. In the study we found a correspondence between erythrocyte CAT and GR activities and leukocyte HSP70 levels, principally 3 h after the acute exercise, and this suggested an integrated mechanism of antioxidant defense. The increase in levels of plasma Tau was coincident with the increasing plasma levels of CK and TBARS, principally after two hours of exercise. Thus tissue damage occurred before the expression of any anti-oxidant system markers and the monitoring of Tau, CK or TBARS may be important for the estimation of oxidative stress during exhaustive exercise. Furthermore, the integrated analyses could be of value in a clinical setting to quantify the extent of oxidative stress risk and reduce the need to perform muscle biopsies as a tool of clinical evaluation.     

The Effect of Religious Clothing on Gaze Behavior: An Eye-Tracking Experiment

There are very few experimental studies regarding religious clothing. In the current study, we hypothesized that the function of conservative clothing hiding female curvaceous body features is to restrict visual access and consequently decreases female physical attractiveness. Using eye-tracking, we quantified dwell times and number of fixations on religious clothing, ranging from conservative to liberal. Results showed that conservative religious clothing decreased visual access to female curvaceous body features and instead focused visual attention to the head/face region. Results were discussed in terms of the roles of conservative clothing in women’s clothing choice, men’s mate retention tactics, and parent-offspring conflict over mate choice.     

Gender relations,the gendered division of labour and health: the case of the women factory workers of Rio Tinto,northeast Brazil, 1924-91

This article examines gendered work-health relationships among female factory workers in Rio Tinto, a textile factory town in Brazil. The author draws on her own and her parents' experiences as factory workers and as residents of Rio Tinto. In addition, she gathered research during 1982-86 and 1988-93, interviewing 30 female and 12 male workers. Findings from 1924-58 and 1959-91 indicate that the family structure and work process were interlinked. Self-images are construed to be the intersection of social relations of sex and class, psychopathology, and the concept of work positions. Gendered relations are a social construction, and awareness of these relations is based on a hierarchy and form of power based on a gendered division of labor. Gendered relations arise out of a specific historical context. Social practices reflect the relationship between sexual division of labor and gendered social relations, their modalities, shape, and periodization. The work-health relationship is expressed in the gendered technical organization of work, the gendered socialization of work, and domestic labor. The period of 1917-58 reflects the capitalist influences. When women became wage earners, their management of household tasks was changed. Men took over the heavy tasks, and women performed tasks that required skill and patience. Work-related health impacts, such as deformed knees or severed fingers, and accidents varied with the task. Women adapted to work conditions. During the 1940s, female workers refused to join the collective protests of men for better wages and conditions. The dream of progress faded by 1964. After 1959, new gendered relations of production and reproduction emerged. Labor laws were passed; new machines were introduced. During 1965-70, the health issues were headaches, irritability, and anxiety. 1970-91 brought a hollowness of spirit and the search for an explanation for the violence they had experienced.     

Relative age effect in Olympic Taekwondo athletes

Relative age effects refer to the effects of age differences among individuals who have been grouped together for a performance activity. This study aimed to investigate the relative age effect on Olympic Taekwondo athletes, in several Olympic Games, and in both sexes. The study sample consisted of 291 athletes who had competed in Atlanta, Sydney, and Beijing Olympic Games. The relative age effect was examined for the general distribution of athletes by quartile, for each of the individuals, and for male and female athletes. There were no discernable effects of relative age on Olympic Taekwondo athletes.     

Self-reference is a fast-acting automatic mechanism on emotional word processing: evidence from a masked priming affective categorisation task

This study examined the impact of self-referential information at early stages of emotional word processing using an affective masked-priming paradigm in which positive (e.g, espetacular[awesome]) and negative (e.g., horrível[awful]) trait-adjectives were preceded by briefly primes that could be self-related (Eu sou[I am]), other-related (Ela é[She is]), or a control (%%%%%). Trait-adjectives were selected from female norms and only females participants were used to control for sex differences. Results showed that positive words were categorised faster when preceded by self-related primes than by other-related primes, though not control primes. Negative trait-adjectives were not modulated by the type of prime, even though participants were slower when they were preceded by other-related than by control primes. These findings demonstrate that taking the other-perspective entails a cost, and that the amount of priming produced by self-related and control primes was virtually the same, thus suggesting that assuming the self-perspective is a cognitively effortless process.     

Influence of wearing an unstable shoe construction on compensatory control of posture

This study investigated the influence of wearing unstable shoe construction (WUS) on compensatory postural adjustments (CPA) associated with external perturbations. Thirty-two subjects stood on a force platform resisting an anterior-posterior horizontal force applied to a pelvic belt via a cable, which was suddenly released. They stood under two conditions: barefoot and WUS. The electromyographic (EMG) activity of gastrocnemius medialis, tibialis anterior, rectus femoris, biceps femoris, rectus abdominis, and erector spinae muscles and the center of pressure (CoP) displacement were acquired to study CPA. The EMG signal was used to assess individual muscle activity and latency, antagonist co-activation and reciprocal activation at joint and muscle group levels. Compared to barefoot, WUS led to: (1) increased gastrocnemius medialis activity, (2) increased total agonist activity, (3) decreased antagonist co-activation at the ankle joint and muscle group levels, (4) increased reciprocal activation at the ankle joint and muscle group levels, and (5) decrease in all muscle latencies. No differences were observed in CoP displacement between conditions. These findings demonstrate that WUS led to a reorganization of the postural control system associated to improved performance of some components of postural control responses.