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OBJECTIVE: Compare the efficacy of a multicomponent social support intervention to standard-of-care counseling on medication adherence among HIV-infected patients initiating antiretroviral therapy. DESIGN: Randomized controlled trial. Generalized estimating equations tested for differences in the percentage of participants achieving 90% adherence. MAIN OUTCOME MEASURES: Pill-taking, electronically monitored over 6 consecutive months; plasma viral load (VL), assessed at 3 and 6 months following initiation of therapy. RESULTS: Of 226 participants who were randomized and began the trial, 87 (38%) were lost to the study by 6 months. The proportion of adherent participants declined steadily over time, with no time by group interaction. Sustained adherence was associated with increased odds of achieving an undetectable VL (OR=1.78; 95% CI=1.01, 3.13). In intention-to-treat analyses, a larger proportion of the intervention group than the control group was adherent (40.15% vs. 27.59%, p=.02) and achieved an undetectable VL p=.04). However, the majority of participants who remained on study experienced some reduction in VL (>or=1-log drop or undetectable), regardless of experimental condition. CONCLUSION: The multicomponent social support intervention significantly improved medication adherence over standard-of-care counseling; evidence for improved virologic outcomes was inconsistent. Early discontinuation of care and treatment may be a greater threat to the health of HIV patients than imperfect medication-taking.  相似文献   
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The current study hypothesized that (1) hope would negatively predict burdensomeness, thwarted belongingness, and acquired capability to enact lethal injury; (2) hope would negatively predict suicidal ideation; and (3) the interpersonal suicide risk factors would predict suicidal ideation. Results indicated that hope negatively predicted burdensomeness and thwarted belongingness, but positively predicted acquired capability to enact suicide. Contrary to our second hypothesis, hope did not predict suicidal ideation, but interpersonal risk factors for suicide predicted suicidal ideation. Results are discussed in terms of implications for hope theory and Joiner's (2005) interpersonal risk factors for suicide, and for clinical practice.  相似文献   
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The structure of businesses and the structure of families are very similar, considering the fact that so many businesses are owned or operated by families. Structural family therapists who are knowledgeable in systems theory and have an adequate understanding of the underlying concepts of structural family theory (including hierarchy, boundaries, and coalitions) can translate their knowledge to the structure of businesses and organizations. The purpose of this paper is to illustrate the similarities between the structures of families and businesses. In doing so, an application of structural family theory to the business world (employee assistance programs, business consultation, and family businesses) will be demonstrated.  相似文献   
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Dyslexic and normal control subjects memorized simple line patterns inside a grid and subsequently judged whether an "X" would have fallen on the pattern had it been present in an empty grid. The patterns were letters and novel shapes. The grids were presented to the left visual field, to the right visual field, or in central vision. Dyslexic subjects had difficulty generating images of multipart patterns, but this deficit was limited to letters. The findings suggest that dyslexics may have selective difficulty integrating visual information stored in long-term memory.  相似文献   
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This study surveyed a randomly selected group of Approved Supervisors of the American Association for Marriage and Family Therapy (n = 280) and their supervisees (n = 266) on their perceptions of the primary supervisor interpersonal skill used in supervisory incidents that had a positive effect on supervisee development. Supervisor directiveness was the most identified skill by both supervisors and supervisees.This study was funded in part by grants from the Research Committee of the American Association for Marriage and Family Therapy; the Agricultural Experiment Station, Purdue University; and the School of Liberal Arts and Sciences, Purdue University Calumet.  相似文献   
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Based on the content analysis of quantitative research appearing in three medical journals, the authors conclude that, despite the shared ideal of providing spiritual care to patients on the part of physicians and chaplains, there is little attention given in these journals demonstrating and promoting this shared perspective. Suggestions for future research that would focus on this common medicine/religion interface and concern are noted.  相似文献   
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It is commonly assumed across the language sciences that some semantic participant information is lexically encoded in the representation of verbs and some is not. In this paper, we propose that semantic obligatoriness and verb class specificity are criteria which influence whether semantic information is lexically encoded. We present a comprehensive survey of the English verbal lexicon, a sentence continuation study, and an on-line sentence processing study which confirm that both factors play a role in the lexical encoding of participant information.  相似文献   
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