Peculiar aspects of reading and writing performances in patients with olivopontocerebellar atrophy

Olivopontocerebellar atrophy (OPCA) is a still debated condition, of which motor disruption is the most common feature. A high incidence of associated mood disorders may exist, but there are few studies on concomitant cognitive impairment. Our aim was to assess whether there is reading and writing disruption in olivopontocerebellar atrophy (OPCA). 6 patients were administered different reading and writing tasks. Scores were then compared to those obtained by healthy volunteers. There was an evident impairment in reading and writing execution in our patients compared to those of the control group. On the contrary, no difference could be found in abstraction, problem-solving, and memory tasks. We discuss the results, debating the role of the cerebellum in the conscious process of cognition or in ocular movement control (necessary for reading and writing fluidity and effective execution) and in the dynamic activation of all the cerebral cortex mediated by the diffuse projection to the reticular system.     

Suicide compared to other causes of mortality in physicians

Physicians frequently are early adopters of healthy behaviors based on their knowledge and economic resources. The mortality patterns of physicians in the United States, particularly suicide, have not been rigorously described for over a decade. Previous studies have shown lower all-cause mortality among physicians yet reported conflicting results about cause-specific mortality such as suicide. In this study, we compared all-cause and cause-specific mortality in a sample of physicians to the age-gender matched general U.S. population from 1948 through 1998. We also compared the mortality experience across medical specialties. The risk of all-cause mortality was 56% lower than expected in men, and 26% lower in women, compared to the general population. Standardized mortality ratios (SMRs) were markedly lower for diseases strongly linked to smoking, e.g., cardiovascular diseases, respiratory diseases, and lung cancer. Suicide was the only cause of death where risk was greater than the general population. Overall, we found that physicians are at substantially lower risk of dying compared to the general population for all causes of death except suicide. The findings for suicide are strikingly different than other causes of death and should provide impetus for new research on the mental health of physicians.     

Writing errors by normal subjects

Writing is a complex process requiring visual memory, attention, phonological and semantic operations, and motor performance. For that reason, it can easily be disturbed by interfering with attention, memory, by interfering subvocalization, and so on. With 16 female third-year students (23.4 +/- 0.8 yr.) from the University of Trieste, we investigated the production of errors in three experimental conditions (control, articulatory suppression, and tapping). In the articulatory suppression condition, the participants produced significantly more linguistic impairments (such as agrammatism, unrelated substitutions, sentence omissions, and semantically deviant sentences), which are similar to linguistic impairments found in aphasia. On the tapping condition there were more perseverations, deletions, and substitutions of both letters and words. These data suggest that writing is not an automatic skill. Only after many years of experience and practice of processing information (through cortical to subcortical channels) can writing be considered an automatic skill. Limited experimental conditions can disrupt the writing system of normal subjects, probably interfering with the cortical to subcortical loops, and link normality to pathology.     

Centered assertion

I suggest a way of extending Stalnaker’s account of assertion to allow for centered content. In formulating his account, Stalnaker takes the content of assertion to be uncentered propositions: entities that are evaluated for truth at a possible world. I argue that the content of assertion is sometimes centered: the content is evaluated for truth at something within a possible world. I consider Andy Egan’s proposal for extending Stalnaker’s account to allow for assertions with centered content. I argue that Egan’s account does not succeed. Instead, I propose an account on which the contents of assertion are identified with sets of multi-centered worlds. I argue that such a view not only provides a plausible account of how assertions can have centered content, but also preserves Stalnaker’s original insight that successful assertion involves the reduction of shared possibilities.     

Coordination Dynamics of the Bipedal Galloping Pattern

A motion equation in relative phase was developed that incorporates the spatial-temporal pattern of the bipedal gallop along with the more commonplace patterns of the bipedal jump and walk-run. In 3 experiments, human participants (N = 6 per experiment) simulated the bipedal gait patterns through the rhythmic motions of hand-held pendulums. Predictions of the motion equation for coordination equilibria and their respective degrees of stability were confirmed. In particular, the gallop pattern was less stable than the fundamental in-phase and antiphase patterns but changed in qualitatively similar ways to those gaits as a function of limb asymmetry and movement frequency. The relation between the modeled coordination dynamics and the kinematic characteristics of real bipedal galloping is discussed.     

Design strategy for microalloyed ultra-ductile magnesium alloys

This article describes a design strategy deployed in developing ultra-ductile Mg alloys based on a microalloying concept, which aims to restrict grain growth considerably during alloy casting and forming. We discuss the efficiency of the design approach, and evaluate the resulting microstructural and mechanical properties. After processing, the so-designed alloys ZQCa3 (Mg–3Zn–0.5Ag–0.25Ca–0.15Mn, in wt.%) and ZKQCa3 (Mg–3Zn–0.5Zr–0.5Ag–0.25Ca–0.15Mn, in wt.%) reveal very fine grains (<10 µm), high ductility (elongation to fracture of up to 30%) at moderate strength or high strength (ultimate tensile strength of up to 350 MPa) at reasonable ductility. These properties are explained based on thermodynamic modelling, microstructure analysis including transmission electron microscopy studies, and microstructural and mechanical testing after annealing, and are compared to a related commercial alloy (ZK31).     

The Catholic Diocese: A Transversalized Institution

The Catholic Church is built, on the one hand, upon a hierarchical structure and vertical relationships, with stratified duties, centered around an organizational culture which is based on strict obedience to institutional directives and which has a monopoly on the administration of the goods and resources concerning salvation. On the other hand, since the Second Vatican Council, the Church has proposed to incorporate lay people into God's Kingdom, a development which represents an opening to the active participation of diverse groups and a redistribution of access to the goods of salvation. Analysts may take a position one way or the other regarding their definition of the Church, and some even state the existence of a dominant church and a people's church. In contrast to both these perspectives, this paper looks at a methodological and theoretical model for studying diversity within Catholic unity. The model is based on the concept of the 'transversalized institution' as it is applied to the way in which Guadalajara's diocese functions.