Inhibition of the LH Surge by Restraint Stress in Cyclic Rats: Studies on the Role of GABAA and GABAB Receptors

There is evidence that stress can alter the activity in the brain of gamma-aminobutyricacid (GABA), a neurotransmitter that has been implicated in the regulation of LH secretion. In the present study the role of GABA in the restraint stress-induced inhibition of the LH surge was investigated in the intact cyclic rat. Intracerebroventricular (icv) administration of the GABAA receptor agonist muscimol (0.1, 0.5 or 1 μg) 5 min before the presumed onset of the pro-oestrous LH surge (at 0900 h) caused a dose dependent suppression of the surge. A single dose of the GABAB receptor agonist baclofen (1 μg; icv) injected at 0855 h postponed the onset of the LH surge, and repeated injections at 0855 and 1130 h suppressed the surge. These data indicate that GABA-ergic activity in the brain can inhibit the LH surge in the cyclic rat via GABAA and GABAB receptors. Pro-oestrous rats were subjected to 5 hrs of restraint starting at 0855 h. Pretreatment with the GABAA receptor antagonist bicuculine (1 μg; icv) at 0840, 0940 and 1040 h or pretreatment with the GABAB receptor antagonist phaclofen (10 μg; icv) at 0840 h were ineffective in preventing the restraint-induced inhibition of the LH surge. The results suggest that GABAA and GABAB receptors are not involved in the inhibitory effect of restraint stress on the LH surge.     

Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

Response to John Beebe

This paper briefly describes the history of the professional interaction between psychoanalysts and analytical psychologists in the United States. There has been little public contact between the two groups since the personal feud between Freud and Jung has beer carried forth to the present generation of analysts. The relationship between Otto Rank and Freud and his circle demonstrated many of the same dynamics that were activated between Freud and Jung, who had broken off their relationship ten years earlier; this paper highlights the similarities between Jung's, then Rank's, exile from the psychoanalytic group, Jung's interest in spiritual matters, including his interest in the nature of religious experience, and his questionable dealing with the Nazis during the 1930s have been the stated reason for the taboo set against Jung's writings. Presently there seems to be a growing realization that there are large areas of mutual interest, and both the similarities and differences between the schools need further exploration.     

Side preference in adults for holding infants: contributions of sex and handedness in a test of imagination

Five hundred one right-handers (150 men, 351 women) and 53 left-handers (15 men, 38 women) were asked to imagine holding a young infant in their arms. Right-handers reported significant left-side biases--in 68% of the men and 73% of the women. For left-handers, side preferences were weaker, the left-side bias dropping to 47% for men and 60% for women, with neither figure different from chance. The results are discussed in the context of theory and research on the functional neuroanatomy of attention, emotional arousal, and the generation, maintenance, and manipulation of mental images.     

Imaginative suggestibility and hypnotizability: an empirical analysis.

Hypnotic and nonhypnotic suggestibility were investigated in 2 experiments. In Experiment 1, nonhypnotic suggestibility was suppressed when measured after hypnotic suggestibility, whereas hypnotic suggestibility was not affected by the order of assessment. Experiment 2 confirmed a small but significant effect of hypnosis on suggestibility when nonhypnotic suggestibility was measured first. Nonhypnotic suggestibility was correlated with absorption, fantasy proneness, motivation, and response expectancy, but only expectancy predicted suggestibility when the other variables were controlled. Behavioral response to hypnosis was predicted by nonhypnotic suggestibility, motivation, and expectancy in a model accounting for 53% of the variance. Experiential response to hypnotic suggestion was predicted only by nonhypnotic suggestibility. Unexpectedly, hypnosis was found to decrease suggestibility for a substantial minority of participants.     

Impact of planned movement direction on judgments of visual locations

The present study examined if and how the direction of planned hand movements affects the perceived direction of visual stimuli. In three experiments participants prepared hand movements that deviated regarding direction (“Experiment 1” and “2”) or distance relative to a visual target position (“Experiment 3”). Before actual execution of the movement, the direction of the visual stimulus had to be estimated by means of a method of adjustment. The perception of stimulus direction was biased away from planned movement direction, such that with leftward movements stimuli appeared somewhat more rightward than with rightward movements. Control conditions revealed that this effect was neither a mere response bias, nor a result of processing or memorizing movement cues. Also, shifting the focus of attention toward a cued location in space was not sufficient to induce the perceptual bias observed under conditions of movement preparation (“Experiment 4”). These results confirm that characteristics of planned actions bias visual perception, with the direction of bias (contrast or assimilation) possibly depending on the type of the representations (categorical or metric) involved.     

Group process in Jungian analytic training and institute life

Group process experience for analytic candidates is a neglected dimension of training, and receives little attention in the analytic literature. Jung observed group dynamics, but he never studied them closely, attending instead to the psychology of the individual. Unconscious currents in small groups have been studied by others, most notably by Wilfred Bion, and there are similarities between his theories of the group unconscious and Jung's theories of complexes. Experiential and didactic seminars in group process were added to the analytic curriculum at the C.G. Jung Institute of San Francisco in the early 1990s, leading to changes in the group dynamic of trainees and analysts alike. A discussion of the theories of Bion and Jung are followed by a report on our experiences of facilitating group process for analytic candidates. We give quotes from candidates and analyst members to illustrate the group process and its effects. The need for further study to develop a uniquely Jungian perspective on the unconscious structure and dynamics of the group is suggested.