Use of photic feedback as an adjunct treatment in a case of Miller Fisher syndrome

Photic Feedback treatment of a patient diagnosed with Miller Fisher syndrome has resulted in the rapid and permanent remission of symptoms. During Photic Feedback treatment, the CD20 appeared to be slightly increased. This may have been associated with changes in humoral immunity. The present clinical observation of a single patient suggests that Photic Feedback treatment should be investigated as a possible adjunct therapy for patients who suffer from polyneuropathies, such as Miller Fisher syndrome, within a carefully controlled clinical trial.     

Dispositional and situational coping and mental health status of university students

The results of stress coping studies do not clearly demonstrate whether dispositional and situational coping can predict health status or whether dispositional coping can predict situational coping. The present study used structural equation modeling to test proposed directional relationships. 292 Japanese university students completed questionnaires concerning dispositional and situational coping and mental health status. Analysis showed that dispositional coping predicted situational coping for some coping strategies. In women, an increase in dispositional Problem-solving predicted a reduction in mental distress via situational Problem-solving. The results suggest that, only for Problem-solving by women, dispositional coping is related to mental health status, but only through situational coping.     

Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex

Several lines of evidence suggest that extracellular signal-regulated kinase1/2 (ERK1/2) and dopaminergic system is involved in learning and memory. However, it remains to be determined if the dopaminergic system and ERK1/2 pathway contribute to cognitive function in the prefrontal cortex (PFC). The amount of phosphorylated ERK1/2 was increased in the PFC immediately after exposure to novel objects in the training session of the novel object recognition test. An inhibitor of ERK kinase impaired long-term recognition memory 24 h after the training although short-term memory tested 1 h after the training was not affected by the treatment. The dopamine D1 receptor agonist increased ERK1/2 phosphorylation in the PFC in vivo as well as in cortical neurons in vitro. Microinjection of the dopamine D1 receptor antagonist into the PFC impaired long-term recognition memory whereas the D2 receptor antagonist had no effect. Immunohistochemistry revealed that exposure to novel objects resulted in an increase in c-Fos expression in the PFC. Microinjection of the protein synthesis inhibitor anisomycin into the PFC impaired the long-term recognition memory. These results suggest that the activation of ERK1/2 following the stimulation of dopamine D1 receptors is necessary for the protein synthesis-dependent long-term retention of recognition memory in the PFC.     

Emergence of rhythm during motor learning

Complex motor skill often consists of a fixed sequence of movements. Recent studies show that a stereotyped temporal pattern or rhythm emerges as we learn to perform a motor sequence. This is because the sequence is reorganized during learning as serial chunks of movements in both a sequence-specific and subject-specific manner. On the basis of human imaging studies we propose that the formation of chunk patterns is controlled by the cerebellum, its posterior and anterior lobes contributing, respectively, to the temporal patterns before and after chunk formation. The motor rhythm can assist the motor networks in the cerebral cortex to control automatic movements within chunks and the cognitive networks to control non-automatic movements between chunks, respectively. In this way, organized motor skill can be performed automatically and flexibly.     

An intervention study of the relations of positive affect to the coping strategy of 'finding positive meaning' and health

This study examined the relations of positive affect (PA) to the coping strategy of 'finding positive meaning' and to health. Participants in the intervention group (29 university students) wrote about a happy event once a week in an experimental room and noted happy events each day as homework for four consecutive weeks. In addition, they received a small present each time they left the room after writing. Participants in the control group (29 university students) wrote about and noted trivial neutral events instead of happy events, and they did not receive any small presents. Results showed that PA induced by this manipulation did not significantly enhance coping but did significantly improve health status on several self-report scales.     

Effects of positive and negative affect and emotional suppression on short-term life satisfaction

Relationships between emotional experiences and health and adjustment are influenced by many variables, with emotional suppression (ES) being one of the most influential factors. In the current study, we examined the effects of affect and ES on short-term life satisfaction (LS) measured over the previous week. We also considered the dimension of activation status for both positive affect (PA) and negative affect (NA). The final sample included data collected from 398 undergraduates (184 men and 214 women). Participants answered six questionnaires, two of which were used for another study. All of the tests were of Japanese versions and were answered with regard to the previous week's experiences. Results showed that LS was positively associated with PA and negatively with NA, but that the positive association was stronger for activated PA than deactivated PA, while the negative association was stronger for deactivated NA than activated NA. Furthermore, an interactive effect between deactivated NA and ES on LS was significant in men, where post hoc tests demonstrated that deactivated NA was more negatively associated with LS when ES was higher. This study suggests that activated and deactivated affect differ in their effects on LS. In addition, it is likely that the detrimental effect of deactivated NA on LS is larger when NA is more strongly suppressed. The necessity of interventional research along with the limitations of this study is discussed for future research.     

Stress coping and the adjustment process among university freshmen

The purpose of the present study was to investigate causal relationships between dispositional and situational coping and health status in university freshmen. Two hundred and twenty-nine university freshmen completed questionnaires at Time 1 (immediately after university matriculation) and at Time 2 (approximately three months later) in a short-term, prospective study. Structural equation modeling was used to analyze causal relationships between four coping strategies (i.e., emotion expression, emotional support seeking, cognitive reinterpretation, and problem solving) and four health status variables (i.e., somatic symptoms, anxiety and insomnia, social dysfunction, and depression). Increases in dispositional coping predicted increases in situational coping at certain time points. In addition, increases in dispositional emotion-focused coping, such as emotion expression and emotional support seeking, predicted poor health status. This relationship was mediated by situational coping variables. Finally, increases in dispositional problem-focused coping, such as cognitive reinterpretation and problem solving, predicted better health status. This relationship was direct or indirectly mediated by situational coping variables. Our data suggest that the use of coping skills such as cognitive reinterpretation and problem solving may promote better health and adaptation in university freshmen.     

Predictive and postdictive mechanisms jointly contribute to visual awareness

One of the fundamental issues in visual awareness is how we are able to perceive the scene in front of our eyes on time despite the delay in processing visual information. The prediction theory postulates that our visual system predicts the future to compensate for such delays. On the other hand, the postdiction theory postulates that our visual awareness is inevitably a delayed product. In the present study we used flash-lag paradigms in motion and color domains and examined how the perception of visual information at the time of flash is influenced by prior and subsequent visual events. We found that both types of event additively influence the perception of the present visual image, suggesting that our visual awareness results from joint contribution of predictive and postdictive mechanisms.     

Relation of positive affect with emotion-focused coping in Japanese undergraduates

This study examined the relationships between coping and positive affect and sex differences in those relationships, focusing on emotional expression as an emotion-focused coping strategy. Undergraduates (193 men and 225 women) completed the Center for Epidemiologic Studies-Depression to assess positive affect by using the Positive Affect subscale and the General Coping Questionnaire for measurement of coping. Analysis showed a positive relationship between positive affect and both problem-solving and cognitive reinterpretation, but only for men, while a positive relation between positive affect and emotional expression was found only for women. Also there were no interactions of emotional expression and other coping strategies, such as problem-solving, cognitive reinterpretation, and emotional support-seeking, on positive affect. These findings provide evidence to suggest that the relationship between positive affect and coping should be examined by sex.     

Development of a Japanese version of the Positive and Negative Affect Schedule for Children

In this paper, the Positive and Negative Affect Schedule for Children originally developed in 1999 by Laurent, et al. was adapted for use in Japan. In Study 1, a total of 763 children in Grades 4 to 6 completed this Schedule, and 103 of them completed it again about three months later. Principal factor analysis with promax rotation identified two factors, positive and negative affect, in the Japanese version, whose alphas (over .80) and test-retest correlations (over .50) were sufficient to indicate internal consistency and stability over time. In Study 2, a total of 328 children completed the Japanese version, the Depression Self-rating Scale for Children, and the Trait Form of the State-Trait Anxiety Inventory for Children. Intercorrelations showed convergent and discriminant validity using these self-report measures of depression and anxiety. Overall these data support the reliability and validity of this Japanese version.