Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

The program of geometrization of physics: Some philosophical remarks

In this paper I discuss some philosophical problems concerning the geometrization of physics, and propose that geometrization and unification are strongly combined.     

Sur la syllogistique déontique de Zdzisław Ziemba

Sans résuméAllatum est die 12 Octobris 1970     

Infant crying: Acoustics,perception and communication

This paper first reviews briefly the literature on the acoustics of infant cry sounds and then presents two empirical studies on the perception of cry and noncry sounds in their social-communicative context. Acoustic analysis of cry sounds has undergone dramatic changes in the last 35 years, including the introduction of more than a hundred different acoustic measures. The study of cry acoustics, however, remains largely focused on neonates who have various medical problems or are at risk for developmental delays. Relatively little is known about how cry sounds and cry perception change developmentally, or about how they compare with noncry sounds. The data presented here support the notion that both auditory and visual information are important in caregivers' interpretations of infant sounds in naturalistic contexts. When only auditory information is available (Study 1), cry sounds become generally more recognizable from 3 to 12 months of age; perception of noncry sounds, however, generally does not change over age. When auditory and visual information contradict each other (Study 2), adults tend to perform at chance levels, with a few interesting exceptions. It is suggested that broadening studies of acoustic analysis and perception to include both cry and noncry sounds should increase our understanding of the development of communication in infancy. Finally, we suggest that examining the cry in its developmental context holds great possibility for delineating the factors that underlie adults' responses to crying.     

Past speech therapy experiences of individuals exploring a new stuttering treatment

Perceptions of benefits of speech therapy, success of therapy across clinical settings, reasons for returning to therapy, client-clinician relationships, and clinicians' competency were assessed in 57 participants (47 men, 10 women; M age = 34 yr.) trying a new therapy. A majority of respondents had cumulatively five or more years in therapy and at least two stuttering therapies. Respondents rated university or hospital settings as more successful than services in public schools. 70% of the respondents noted difficulty communicating basic needs; they blamed themselves for inability to maintain posttherapeutic gains while perceiving their clinicians to be competent and attentive--although 47% of the respondents had minimal to no contact with their therapist after therapy.     

Hypothalamo-Pituitary-Adrenocortical Regulation Following Lesions of the Central Nucleus of the Amygdala

Previous reports indicate that the central nucleus of the amygdala (CeA) stimulates adrenocorticotropin and corticosterone secretion, suggesting a role for this region in central hypothalamo-pituitary-adrenocortical (HPA) stress regulation. To evaluate this hypothesis, this study assessed the impact of CeA lesion on the response of hypophysiotrophic paraventricular nucleus (PVN) neurons to acute restraint and chronic unpredictable stress exposure. In contrast to previous reports, CeA lesions did not affect corticosterone or ACTH secretion induced by acute stress. Acute restraint increased PVN corticotropin releasing hormone (CRH) mRNA expression, increased the number of parvocellular PVN neurons expressing the co-secretagogue arginine vasopressin (AVP), and induced cFOS mRNA expression in the parvocellular PVN. However, there was no additional effect of CeA lesion on any measure of PVN activation. Chronic unpredictable stress exposure induced long-term activation of the HPA axis, noted by thymic involution, adrenal hypertrophy and increased PVN CRH mRNA expression. Stress-induced changes in thymus and adrenal weights were not affected by CeA lesion. Further, CeA lesion rats did not differ from controls in post-stress CRH mRNA expression. However, basal CRH mRNA expression was increased in the PVN of CeA rats, suggesting that the CeA plays a role in long-term inhibition of the PVN. The results of these studies are not consistent with the hypothesis that the CeA is necessary for stress-induced pituitary-adrenocortical activation. Rather, this region may play a stressor-specific modulatory role in regulation of HPA function.     

Kolokwium logiki prawa w tuluzie

Centre national de la recherche scientifique paryAllatum est die 8 Februarii 1967     

Theorie des propositions normatives

Sans résumé     

Teoria zdań normatywnych

Allatum est die 14. Maii 1952.