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Experiments 1 and 2 tested the hypothesis that cholinergic receptor antagonists impair place learning in a water maze by interfering with the processing of distal, visual cues. Extramaze cues were offered to rats in the form of geometrical patterns arranged on the inner circumference of a curtain surrounding the water maze. In Experiment 1 the animals were offered both the distal cues and proximal cues in the form of pingpong balls in fixed positions on the surface of the water while only distal cues were present in Experiment 2. Animals were injected with either scopolamine (0.5 mg/kg body wt) or saline 20 min prior to the daily place learning sessions. Upon reaching criterion level performance the animals were tested on "rotation" sessions on which the distal cues were displaced. The outcome of such "rotations" demonstrated that-regardless of the presence or absence of proximal cues-scopolamine-treated rats relied at least as much as normal animals on the distal cues. The acquisition phase of both Experiments 1 and 2 demonstrated an almost complete lack of scopolamine-associated impairment in acquisition and performance of the place learning task. In Experiment 3 (when scopolamine was no longer administered) the subjects of Experiment 2 were exposed to a series of pharmacological "challenges" of their place learning performance and eventually to surgical ablation of the anteromedial prefrontal cortex. The outcome of the pharmacological challenges and the postoperative test of task performance demonstrated that the place learning performance of animals which had acquired the task under scopolamine was mediated by a neural substrate dissimilar to the substrate of task performance in normal animals. Rats acquiring the task while deprived of the cholinergic system demonstrated above-normal contributions to task mediation from catecholaminergic-probably dopaminergic-mechanisms and tentative results pointed to a "shift" toward prefrontal task mediation.  相似文献   
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We propose a functional version of extended redundancy analysis that examines directional relationships among several sets of multivariate variables. As in extended redundancy analysis, the proposed method posits that a weighed composite of each set of exogenous variables influences a set of endogenous variables. It further considers endogenous and/or exogenous variables functional, varying over time, space, or other continua. Computationally, the method reduces to minimizing a penalized least-squares criterion through the adoption of a basis function expansion approach to approximating functions. We develop an alternating regularized least-squares algorithm to minimize this criterion. We apply the proposed method to real datasets to illustrate the empirical feasibility of the proposed method.  相似文献   
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Applied Research in Quality of Life - Empirical studies on work-life balance (WLB) among employees without disabilities are abundant; in contrast, insufficient research exists on WLB and quality of...  相似文献   
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This study investigates the relationship between wisdom and ego‐identity among university students in China. Using Marcia's ego‐identity statuses and Ardelt's wisdom dimensions as the theoretical and conceptual framework, the study investigates 356 university students in China. After exploratory and confirmatory factor analyses, four factors from wisdom and five factors from ego‐identity were retrieved. A structural equation model was then conducted to analyse the relationships. The findings were: (1) among wisdom dimensions, cognitive, and reflective wisdom, especially perspective‐taking best predicted achievement, (2) all three dimensions of wisdom predicted moratorium, but reflective wisdom was the most pronounced predictor, (3) all three dimensions of wisdom predicted diffusion, but resentment items from reflective wisdom were the most pronounced predictors, and (4) gender was a significant predictor of ego‐identity achievement and diffusion. These findings suggest that efforts to build reflective wisdom might contribute to healthier ego‐identity formation.  相似文献   
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Even with the recent surge of research on achievement emotions, few studies have investigated emotions in feedback situations and the appraisals associated with such emotions. The purpose of this study was to examine emotion appraisals of constructive criticism, negative, and positive feedback, to aid us in determining whether these appraisals differed by feedback type. In a task asking them to provide open-ended responses as they imagined receiving feedback on a writing task, undergraduates (N?=?270) gave reasons for why they might experience unpleasant emotions from positive feedback and pleasant emotions from negative feedback along with reasons for both pleasant and unpleasant emotions emanating from constructive feedback. Open coding of responses yielded categories for each emotion-feedback pairing that, across all emotions, were collapsed into five appraisal categories: feedback suggests ways to improve, a mismatch between feedback and task exists, feedback targets the self or one’s ability, feedback says something about the relationship between feedback giver and receiver, and the task is judged for its value. Distributions of appraisal categories distinguished constructive feedback from positive and negative feedback. Implications are drawn for control-value theory and for classroom feedback practices.  相似文献   
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Carbon nanotubes have been intensively studied owing to their great potential in nanoelectronics and nanomechanical devices. Recently, experimental results have shown that single-walled carbon nanotubes (SWCNTs) change their electronic properties when subjected to strain. In this study, the electromechanical characteristics of SWCNT networks were investigated for the application of printable strain sensors on flexible substrates. SWCNT films were formed on plastic substrates of poly(ethylene terephthalate) using a spray process. In this manner, we were able to control the transparency and obtain uniform electrical properties of the films. The films are isotropic on account of the random orientation of bundles of SWCNTs. Experimental results showed a nearly linear change in the resistance across a film when it was subjected to tensile strain, even in the inelastic range of the flexible substrate. The results demonstrate the potential use of SWCNT films for highly sensitive printable strain sensors on a macroscale.  相似文献   
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Background and objectives: Terrorism can heighten fears and undermine the feeling of safety. Little is known, however, about the factors that influence threat and safety perception after terrorism. The aim of the present study was to explore how proximity to terror and posttraumatic stress reactions are associated with perceived threat and safety after a workplace terrorist attack. Design and methods: A cross-sectional questionnaire survey was administered to employees in 14 of 17 Norwegian ministries 9–10 months after the 2011 bombing of the government headquarters in Oslo (n = 3520). Results: About 198 of 1881 employees completing the survey were at work when the bomb exploded. Regression analysis showed that this high-exposed group had elevated perceived threat (β = 0.36; 95% CI = 0.19 to 0.53) and reduced perceived safety (β = ?0.42; 95% CI = ?0.62 to ?0.23) compared to a reference group of employees not at work. After adjusting for posttraumatic stress reactions, however, proximity to the explosion no longer mattered, whereas posttraumatic stress was associated with both high perceived threat (β = 0.55; 95% CI = 0.48 to 0.63) and low perceived safety (β = ?0.71; 95% CI, ?0.80 to ?0.63). Conclusion: Terror-exposed employees feel more threatened and less safe after a workplace terrorist attack, and this is closely linked to elevated levels of posttraumatic stress reactions.  相似文献   
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ABSTRACT

In recent years there has been rapid proliferation of studies demonstrating how reward learning guides visual search. However, most of these studies have focused on feature-based reward, and there has been scant evidence supporting the learning of space-based reward. We raise the possibility that the visual search apparatus is impenetrable to spatial value contingencies, even when such contingencies are learned and represented online in a separate knowledge domain. In three experiments, we interleaved a visual choice task with a visual search task in which one display quadrant produced greater monetary rewards than the remaining quadrants. We found that participants consistently exploited this spatial value contingency during the choice task but not during the search task – even when these tasks were interleaved within the same trials and when rewards were contingent on response speed. These results suggest that the expression of spatial value information is task specific and that the visual search apparatus could be impenetrable to spatial reward information. Such findings are consistent with an evolutionary framework in which the search apparatus has little to gain from spatial value information in most real world situations.  相似文献   
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